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A major barrier for cancer immunotherapy is the presence of suppressive cell populations in patients with cancer, such as myeloid-derived suppressor cells (MDSC) and tumor-associated macrophages (TAM), which contribute to the immunosuppressive microenvironment that promotes tumor growth and metastasis. Tasquinimod is a novel antitumor agent that is currently at an advanced stage of clinical develo

A housewife of many trades: applying history of knowledge to the rationalization of the home in 1946–1956. After World War II, Swedish women were expected to return to their work at home, due to a shortfall of work for men. However, to make housework more attractive for women, its status needed to increase. One way to make housework more appealing for women was to rationalize the home and therefo

To reduce traffic accidents caused by driver factors, realizing technology to monitor and preemptively respond to the state of a driver is necessary. In this study, drivers' electroencephalogram (EEG) data during driving were acquired, and the effect of carelessness warnings was analyzed. The frequency of carelessness per minute was low for the case of presence of warnings. The originality of this

Synovial sarcoma (SyS) is an aggressive soft-tissue malignancy that is characterised by a pathognomonic t(X;18)(p11.2;q11.2) translocation, which produces the fusion oncogene named SS18::SSX. Despite recent advancements in our understanding of synovial sarcoma biology, the cell-of-origin remains undefined. A mesenchymal stromal cell (MSC) specific CreERT2 line was employed to express SS18::SSX in

Efficient management of on-demand delivery systems is essential for modern urban logistics, especially in densely populated cities with complex spatial layouts. This study introduces a novel, computer-supported cooperative framework that utilizes Infomap-based hierarchical community detection to analyze spatial multilevel clustering patterns. The experiment was conducted to large scale on-demand d

Progress with respect to enrichment and separation of native membrane components in complex lipid environments, such as native cell membranes, has so far been very limited. The reason for the slow progress can be related to the lack of efficient means to generate continuous and laterally fluid supported lipid bilayers (SLBs) made from real cell membranes. We show in this work how the edge of a hyd

Purpose: Functional outcomes vary between centers after out-of-hospital cardiac arrest (OHCA) and are partially explained by pre-existing health status and arrest characteristics, while the effects of in-hospital treatments on functional outcome are less understood. We examined variation in functional outcomes by center after adjusting for patient- and arrest-specific characteristics and evaluated

Background: The EsPhALL2004 randomised trial showed a 10% advantage in disease-free survival for short, discontinuous use of imatinib after induction compared with no use of imatinib in patients with Philadelphia chromosome-positive acute lymphoblastic leukaemia receiving Berlin-Frankfurt-Münster chemotherapy and haemopoietic stem-cell transplantation (HSCT). Other contemporary studies showed an a

Introduction: The spatial peaks QRS-T angle accurately distinguishes children with hypertrophic cardiomyopathy from their healthy counterparts. The spatial peaks QRS-T angle is also useful in risk stratification for ventricular arrhythmias. We hypothesised that the spatial peaks QRS-T angle would be useful for the prediction of ventricular arrhythmias in hypertrophic cardiomyopathy patients under

The molecular epidemiology of HIV-1 in Iceland has not been described so far. Detailed analyses of the dynamics of HIV-1 can give insights for prevention of virus spread. The objective of the current study was to characterize the genetic diversity and transmission dynamics of HIV-1 in Iceland. Partial HIV-1 pol (1020bp) sequences were generated from 230 Icelandic samples, representing 77% of all H

Becoming a father, especially for the first time, can present changes in men's identity and in the relationship with their partner. Affinity within the family and participation in the whole process of pregnancy, childbirth and the postnatal period are important for fathers' sense of postnatal security. The fathers want to be already prepared before birth for the early postnatal period. Willingness

Background Perfluoroalkyl substances (PFASs) are bio-accumulative pollutants, and prenatal exposure to PFASs is believed to impact human foetal development and may have long-term adverse health effects later in life. Additionally, maternal cigarette smoking may be associated with PFAS levels. Foetal exposure has previously been estimated from umbilical cord plasma, but the actual concentration in

Många beteenden hos djur kan vara oflexibla och mer eller mindre ”hard-wired” i hjärnan. Sådana beteenden kan vara ändamålsenliga för regelbundna och rytmiska förändringar i naturen, såsom dag och natt, årstider, etc. Men många faktorer är naturligtvis oförutsägbara i naturen. För sådana oförutsägbara förändringar är det bättre för djur att vara flexibla i sitt beteende. Kognition är en process soThe Paridae (tits, titmice and chickadees) is a bird family consisting of both food hoarding and non-hoarding species. Many studies have been conducted on birds that are considered to be cognitively advanced, such as parrots and corvids, whereas much less is known about these small passerines. In this thesis, I have investigated the cognitive abilities of two members of the Paridae family; marsh t

Background: In Western settings, community-acquired pneumonia (CAP) due to Gram-negative bacilli (GNB) is relatively rare. Previous studies from Asia, however, indicate a higher prevalence of GNB in CAP, but data, particularly from Southeast Asia, are limited. Methods: This is a prospective observational study of 1451 patients ≥15 y of age with CAP from two hospitals in Cambodia between 2007 and 2

The effect of surface strain on the passive film evolution of SAF 2507 super duplex stainless steel exposed to ambient air and 0.1 M NaCl solution with varying anodic polarization at room temperature has been investigated using in-situ grazing incidence X-ray diffraction (GIXRD) in combination with electrochemical measurements. Surface strain affected the crystallinity of the passive film as such

This paper examines the response of five prominent Swedish economists, David Davidson, Gustav Cassel, Eli Heckscher, Knut Wicksell and Bertil Ohlin, to John Maynard Keynes’s "The Economic Consequences of the Peace" and to the German reparations in the 1920s. When Keynes’s book appeared, Davidson and Cassel strongly endorsed it. Heckscher also agreed with Keynes – “a bright spot in a time of darkne

PURPOSE: To document and analyse the decision to withhold or withdraw life-sustaining treatment (LST) in a population of very old patients admitted to the ICU.METHODS: This prospective study included intensive care patients aged ≥ 80 years in 309 ICUs from 21 European countries with 30-day mortality follow-up.RESULTS: LST limitation was identified in 1356/5021 (27.2%) of patients: 15% had a withho