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Background: During wound healing processes fibroblasts account for wound closure by adopting a contractile phenotype. One disease manifestation of COPD is emphysema which is characterized by destruction of alveolar walls and our hypothesis is that fibroblasts in the COPD lungs differentiate into a more contractile phenotype as a response to the deteriorating environment. Methods: Bronchial (centra

Pulmonary arterial hypertension (PAH) is a life-threatening condition with no cure, making research into its underlying mechanisms critical. The platelet-derived growth factor (PDGF) signaling pathway plays a crucial role in vascular remodeling, a key factor in PAH progression. Anti-PDGF receptor therapies, such as imatinib, show promise but are associated with significant side effects. Recent res

Visual localization enables autonomous vehicles to navigate in their surroundings and augmented reality applications to link virtual to real worlds. Practical visual localization approaches need to be robust to a wide variety of viewing condition, including day-night changes, as well as weather and seasonal variations, while providing highly accurate 6 degree-of-freedom (6DOF) camera pose estimate

Molecular changes occurring during invasion and clinical progression of cancer are difficult to study longitudinally in patient-derived material. A unique feature of urothelial bladder cancer (UBC) is that patients frequently develop multiple nonmuscle invasive tumors, some of which may eventually progress to invade the muscle of the bladder wall. Here, we use a cohort of 73 patients that experien

The current view of type 1 diabetes (T1D) is that it is an immune-mediated disease where lymphocytes infiltrate the pancreatic islets, promote killing of beta cells and cause overt diabetes. Although tissue resident immune cells have been demonstrated in several organs, the composition of lymphocytes in human healthy pancreatic islets have been scarcely studied. Here we aimed to investigate the ph

BACKGROUND Targeted temperature management is recommended for patients after cardiac arrest, but the supporting evidence is of low certainty. METHODS In an open-label trial with blinded assessment of outcomes, we randomly assigned 1900 adults with coma who had had an out-of-hospital cardiac arrest of presumed cardiac or unknown cause to undergo targeted hypothermia at 33°C, followed by controlled

We have studied somatic mutation activity early in a response to 2-phenyl-5-oxazolone coupled to ovalbumin (phOx-OVA). Although the V kappa Ox1 gene rearranged to J kappa 5 is known to predominate in this response, other closely related V kappa genes are involved. We compared the introduction of point mutations into V kappa Ox1 genes and into a set of related V kappa genes rearranged to the same J

Background: The interaction of allergens and allergen-specific IgE initiates the allergic cascade after crosslinking of receptors on effector cells. Antibodies of other isotypes may modulate such a reaction. Receptor crosslinking requires binding of antibodies to multiple epitopes on the allergen. Limited information is available on the complexity of the epitope structure of most allergens. Object

Importance: Cancer is the second leading cause of death worldwide. Current estimates on the burden of cancer are needed for cancer control planning.Objective: To estimate mortality, incidence, years lived with disability (YLDs), years of life lost (YLLs), and disability-adjusted life-years (DALYs) for 32 cancers in 195 countries and territories from 1990 to 2015.Evidence Review: Cancer mortality w

As a prototype of genomics-guided precision medicine, individualized thiopurine dosing based on pharmacogenetics is a highly effective way to mitigate hematopoietic toxicity of this class of drugs. Recently, NUDT15 deficiency was identified as a genetic cause of thiopurine toxicity, and NUDT15-informed preemptive dose reduction was quickly adopted in clinical settings. To exhaustively identify pha

Purpose: The study aimed to investigate expression of epithelial-to-mesenchymal transition (EMT)-related proteins and phenotypes during breast cancer progression and to relate this to patient outcome. Methods: Protein expression patterns of E-cadherin, N-cadherin, twist, and vimentin were examined by immunohistochemistry on formalin-fixed paraffin-embedded samples from primary tumors (PTs) (n = 41

Amplification of fibroblast growth factor receptor 1 (FGFR1) in non-small cell lung cancer (NSCLC) has been considered as an actionable drug target. However, pan-FGFR tyrosine kinase inhibitors did not demonstrate convincing clinical efficacy in FGFR1-amplified NSCLC patients. This study aimed to characterise the molecular context of FGFR1 expression and to define biomarkers predictive of FGFR1 in

Introduction: During airway infection, upregulation of proinflammatory cytokines and subsequent immune cell recruitment is essential to mitigate bacterial infection. Conversely, during prolonged and non-resolving airway inflammation, neutrophils contribute to tissue damage and remodeling. This occurs during diseases including cystic fibrosis (CF) and COPD where bacterial pathogens, not least Pseud

Damsgård_etal The 2nd EuroSoTL conference, June 8-9 2017, Lund, Sweden Are learning outcomes affected by course intensity and workload? B. Damsgård, E. Strømseng & Ø. Varpe The University Centre in Svalbard (UNIS), P.O. Box 156, 9171 Longyearbyen, Norway ABSTRACT: University courses may be organized as parallel semester courses, or as sequential intensive courses ranging from a few weeks to severa

https://konferens.ht.lu.se/fileadmin/_migrated/content_uploads/Damsga__rd_etal.pdf - 2026-05-11

Civilingenjör i elektroteknik | LTH, Lunds Tekniska Högskola Hoppa till huvudinnehåll Vi använder cookies och andra spårningsteknologier för att förbättra användarupplevelsen på vår webbplats, för att visa dig personligt innehåll och riktade annonser och för att analysera vår webbplatstrafik. Läs mer om cookies. Absolut nödvändiga cookies Dessa cookies är nödvändiga för att webbplatsen ska fungera

https://www.lth.se/utbildning/elektroteknik/ - 2026-05-14

Matematikcentrum Matematik NF Sammanställning för MATA22 Lineär algebra 1, vårterminen 2020 Kursansvarig: Anna-Maria Persson Övriga lärare: Henrik Ekström Antal studenter: 63 nyregistrerade samt 27 omregistrerade. 21 studenter har svarat på utvärderingen. Resultat på examinerande moment: - Projektuppgifter: 48 studenter klara med samtliga inlämningsuppgifter - Skriftlig tentamen: 44 godkända stude

https://www.maths.lu.se/fileadmin/maths/Matematik_NF/Kursutvaerderingar/VT2020/MATA22CAVT2020.pdf - 2026-05-14

Trygg i starten, stark i längden Trygg i starten, stark i längden – Vikten av introduktion för nyexaminerade En rapport från Saco i samarbete med Saco studentråd Trygg i starten, stark i längden Vikten av introduktion för nyexaminerade Hedvig Modin © Hedvig Modin och Karin Fristedt Saco 2025 www.saco.se 1 Innehåll Sammanfattning 2 Nuläge och forskning 3 Starten i arbetslivet 3 Framgångsfaktorer fö

https://www.saco.se/contentassets/d8e1a375defd4210b27781576f0f1e4c/trygg-i-starten-stark-i-langden---vikten-av-introduktion-for-nyexaminerade_saco-2025.pdf - 2026-05-15

Aktuellt om v&h diabetes final.indd 1 A K T U EL LT O M V E T ENSK A P O CH HÄ L SA • J U N I 20 05 Leva med diabetes Juni 2005 Denna tidskrift ges ut av Medicinska fakulteten vid Lunds universitet och Universitetssjukhuset i Lund & Universitetssjukhuset MAS vid Region Skåne Aktuellt om VETENSKAP & HÄLSA 2 A K T U EL LT O M V E T ENSK A P O CH HÄ L SA • J U N I 20 05 Aktuellt om VETENSKAP & HÄLSA

https://www.vetenskaphalsa.se/wp-content/uploads/2010/08/Aktuellt_om_vet_o_halsa_maj_05.pdf - 2026-05-14