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The Iberian ribbed newt (Pleurodeles waltl) constitutes a central model for probing the basis of vertebrate regeneration. Here, we present the sequencing and chromosome-scale assembly of the 20.3Gb P. waltl genome, which exhibits the highest level of contiguity and completeness among giant genome assemblies. We uncover that DNA transposable elements are the major contributors to its expansion, wit
Green ammonia synthesis from nitrogen via photocatalysis and electrocatalysis has emerged as a pivotal research focus in sustainable chemical processes. The efficient catalytic reduction of nitrogen necessitates concurrent nitrogen activation and hydrogen evolution suppression, representing a significant challenge. In this study, CuAu bimetallic-modified TiO2 catalysts were developed and engineere
This article explores the complex relationship between performance programs in higher music education and the evolving demands of current and future professional music scenes. Drawing upon career anchor theory and enactive cognitive science, it introduces a workshop-based framework to support students in reflecting on future working life. The framework decenters ideas of entrepreneurship and marke
Let (Formula presented.) be a (Formula presented.) -adic analytic pro- (Formula presented.) group of dimension (Formula presented.), with lower (Formula presented.) -series (Formula presented.). We produce an approximate series which descends regularly in strata and whose terms deviate from (Formula presented.) in a uniformly bounded way. This brings to light a new set of rational invariants (Form
UNLABELLED: Systemic targeted therapy in prostate cancer is primarily focused on ablating androgen signaling. Androgen deprivation therapy and second-generation androgen receptor (AR)-targeted therapy selectively favor the development of treatment-resistant subtypes of metastatic castration-resistant prostate cancer (mCRPC), defined by AR and neuroendocrine (NE) markers. Molecular drivers of doubl
The Large Hadron Collider (LHC) at CERN became operational in 2009 and has since then produced a plethora of physics results from proton–proton (pp) collisions. This short review covers results that relate to soft quantum chromodynamics (QCD) with a focus on nondiffractive physics at midrapidity. Most of the presented results are based on transverse momentum spectra and related derived observables
The current paper focuses on the conceptual design and numerical analysis of a four-stage centrifugal pump for the fuel system of a turbofan engine with liquid hydrogen as fuel. Liquid hydrogen is challenging at high pressures due to its special fluid properties. The design condition for the pump is set at take-off, to raise the pressure of liquid hydrogen from 6 bars at the outlet of a low-pressu
BackgroundBreathlessness is a common and distressing symptom across a wide range of medical conditions. Different aspects (dimensions) of breathlessness can be assessed using the Multidimensional Dyspnoea Profile (MDP) and Dyspnoea-12 (D12) questionnaires. We aimed to examine whether the order of completing MDP and D12 affects the breathlessness responses in people with cardiorespiratory disease.M
This special issue deals with temporalities in migration law with particular emphasis on the European context. At the crossroads of several legal fields, including public law, human rights law, EU law and public international law, the topic is cutting-edge in migration law. The articles collected were originally presented at a conference organized at Vrije Universiteit in Amsterdam in June 2023 an
Historically, research on nonavian reptile communication has emphasized visual, tactile, and chemical modalities. Recently, growing evidence highlights the significance of acoustic signals in intra- and interspecies interactions. Reptiles produce sounds to mediate social behaviors such as reproduction, parent–offspring interactions, and territorial defense. Many species were found to have diverse
The adsorption of soft microgels at interfaces is a key phenomenon in numerous applications, including emulsification, interfacial stabilization, and responsive coatings. In this work, we employ a combination of in situ atomic force microscopy and numerical simulations to systematically investigate the structural behavior of individual microgels at liquid-liquid and solid-liquid interfaces. By dir
The end-Permian mass extinction greatly affected the sedimentary record, but the sedimentary response was not limited to the Permian-Triassic boundary interval. This transformation extended to sedimentation that spanned the entire Early Triassic. Calcimicrobialites play an important role throughout this time interval, and at least four main events of anomalous carbonate deposition can be shown. A
Context. Studies of the internal kinematics of the LMC have provided a detailed view of its structure, largely thanks to the exquisite proper motion data supplied by the Gaia mission. However, line-of-sight (LoS) velocities, the third component of the stellar motion, are only available for a small subset of the current Gaia data, thus limiting studies of the kinematics perpendicular to the LMC dis
Based on a combination of morphometric analyses, a chloroplast DNA phylogeny, and multivariate analyses of whole genome sequence data from >300 museum samples, we discuss and evaluate the delimitation, taxonomy, and evolution of wild and escaped taxa in Mentha subgen. Mentha, focusing on the northern hemisphere. Thirteen species (Mentha aquatica, M. arvensis, M. australis, M. capensis, M. dahurica
Obesity represents a global health challenge, with a critical and urgent need for long-term, sustainable management strategies. Tirzepatide is a novel dual glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (GLP-1) receptor agonist. At first approved for the treatment of type 2 diabetes mellitus, tirzepatide represents one of the latest clinically approved and commercia
The robotic future is nearly here, and East Asia stands at the forefront of this shift. East Asian firms innovating in this sector are backed in various ways by governments committed to competing for leadership in robotics. This field promises to unleash heightened productivity and precision in manufacturing, while the opportunities in services are also enormous. The expanded installation of robot
Although groundwater serves as the predominant source of drinking water across many rural regions and certain urban areas of Rwanda, little is known about this resource. Anthropogenic impacts, such as faecal contamination, as well as geogenic water quality problems, including elevated arsenic, fluoride, iron, and manganese, are among the issues of concern for groundwater quality in Rwanda. Long-te
