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This paper presents initial research within a broader discourse about smart cities. Despite the existence of various discussions about the concept many questions are still opened. We bridge the gap by investigating the role of local governments and their initiatives to integrate new technologies in a city context. The study aims to investigate the adoption of technological innovation in smart citi
Importance: Blood phosphorylated tau (p-tau) and amyloid-β peptides (Aβ) are promising peripheral biomarkers of Alzheimer disease (AD) pathology. However, their potential alterations due to alternative mechanisms, such as hypoxia in patients resuscitated from cardiac arrest, are not known. Objective: To evaluate whether the levels and trajectories of blood p-tau, Aβ42, and Aβ40 following cardiac a
Deficiencies of the early complement components of the classical pathway (CP) are well-documented in association with systemic lupus erythematosus (SLE) or SLE-like syndromes and severe pyogenic infections. Among these, complete C1s deficiency has been reported in nine cases so far. Here, we describe a 34-year-old male patient who presented with severe, recurrent infections since childhood, includ
In recent years, research interest in second language use and acquisition beyond the classroom has grown considerably. However, terminological confusion and definitional differences have made it difficult to compare findings and discover trends across studies, and more broadly synthesise new insights and developments. Therefore, this scoping review is intended to provide an overview of when, where
Fine mapping and bioinformatic analysis of the DDX6-CXCR5 genetic risk association in Sjögren's Disease (SjD) and Systemic Lupus Erythematosus (SLE) identified five common SNPs with functional evidence in immune cell types: rs4938573, rs57494551, rs4938572, rs4936443, rs7117261. Functional interrogation of nuclear protein binding affinity, enhancer/promoter regulatory activity, and chromatin-chrom
Activating FLT3 and RAS mutations commonly occur in leukemia with KMT2A-gene rearrangements (KMT2A-r). However, how these mutations cooperate with the KMT2A-r to remodel the epigenetic landscape is unknown. Using a retroviral acute myeloid leukemia (AML) mouse model driven by KMT2A::MLLT3, we show that FLT3ITD, FLT3N676K, and NRASG12D remodeled the chromatin accessibility landscape and associated
Objectives: Positive resection margins after breast-conserving surgery (BCS) most often demands a repeat surgery. To preoperatively identify patients at risk of positive margins, a multivariable model has been developed that predicts positive margins after BCS with a high accuracy. This study aimed to externally validate this prediction model to explore its generalizability and assess if additiona
Purpose: The study aims to advance the understanding of collaborative consumption through the research on the engagement rules, conventions, and norms that govern the practice. The study postulates that it is through the possession of the right competences and meaning that permit insiders to successfully apply the rules of collaborative consumption while deterring outsiders from making an initial
Ett patent är en immateriell rättighet som medför en ensamrätt för patenthavaren att dra affärsmässig nytta av en viss uppfinning under en begränsad tidsperiod. Den som kränker patenthavarens ensamrätt gör sig skyldig till patentintrång. Vid patentintrång tillhandahåller den svenska patentlagen (1967:837) ett antal olika sanktionsmöjligheter. De primära civilrättsliga sanktionsformerna utgörs av pA patent is a kind of intellectual property right that grants the patent holder an exclusive right to profit from a certain invention for a limited time period. Anyone who violates the patent holder's exclusive right is guilty of patent infringement. In cases of patent infringement the Swedish Patent Act (patentlag 1967: 837) provides a number of different sanction options. The primary civil s
A computer aided action research method for design of work places is presented. A project group of researchers, managers, union representatives, supervisors, shop-floor workers and representatives from the health-and-safety department analyse different aspects of the physical and organizational work environment. Factory layouts and the flow of raw materials and goods, truck routes and overhead cra
We performed transient absorption (TA) measurements on CP29 minor light-harvesting complexes that were reconstituted in vitro with either violaxanthin (Vio) or zeaxanthin (Zea) and demonstrate that the Zea-bound CP29 complexes exhibit charge-transfer (CT) quenching that has been correlated with the energy-dependent quenching (qE) in higher plants. Simulations of the difference TA kinetics reveal t
Today, innovation is a key word for many universities, as it constitutes an important part of most universities’ public and scientific outreach task. Many universities are striving to increase the number of innovations generated at the university. A common method is to provide various support for research projects e.g.; providing researchers with information about international patent rights (IPR)
The thesis circles around Social Media, B2B Brand Building and Business Performance Measurements. In the intersection between these a knowledge gap was identified. The following research questions were formed: How should companies go about when implementing Social Media? How should the performance of Social Media engagement be measured? The urgency for answering these questions was identified. Th
Background: Selective water uptake by neurons and glial cells and subsequent brain tissue oedema are key pathophysiological processes of hypoxic-ischemic encephalopathy (HIE) after cardiac arrest (CA). Although brain computed tomography (CT) is widely used to assess the severity of HIE, changes of brain radiodensity over time have not been investigated. These could be used to quantify regional bra
INTRODUCTION: Endovascular thrombectomy (EVT) is a significant improvement in the care of acute ischemic stroke (AIS) patients, but only a small portion of patients receive treatment. Our aim was to analyze EVT implementation in Sweden according to a set of key performance indicators (KPIs) for procedural and implementational effectiveness. METHODS: A nationwide prospective registry-based observ
Objective: To explore associations between four methods assessing long-term neurocognitive outcome after out-of-hospital cardiac arrest and early hypoxic-ischemic neuronal brain injury assessed by the biomarker serum neurofilament light (NFL), and to compare the agreement for the outcome methods. Methods: An explorative post-hoc study was conducted on survivor data from the international Target Te
BACKGROUND: A history of preeclampsia is associated with increased risk of coronary artery disease and experimental evidence suggests that a history of preeclampsia also increases the risk of restenosis. However, the extent to which a history of preeclampsia is associated with risk of restenosis after percutaneous coronary intervention in women is unknown. METHODS AND RESULTS: We included 6065 par
This project explores how a beginner friendly music production device can lower the threshold for engaging with sound creation and rhythm making. Many existing tools rely on prior knowledge or technical skill, which discourages new users from experimenting in creative ways. This project instead focuses on quick feedback, clear interaction and a tactile experience that invites curiosity and play. T
