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Galectin-3 is a beta-galactoside-binding mammalian lectin that is one of a 15-member galectin family that can bind several cell surface glycoproteins via its carbohydrate recognition domain (CRD). As a result, it can influence a range of cellular processes including cell activation, adhesion and apoptosis. Galectin-3 has been implicated in various diseases, including fibrotic disorders and cancer,

Among the responders to microbial invasion, neutrophils represent the earliest and perhaps the most important immune cells that contribute to host defense with the primary role to kill invading microbes using a plethora of stored anti-microbial molecules. One such process is the production of reactive oxygen species (ROS) by the neutrophil enzyme complex NADPH-oxidase, which can be assembled and a

Optimal growth and development in childhood and adolescence is crucial for lifelong health and well-being1–6. Here we used data from 2,325 population-based studies, with measurements of height and weight from 71 million participants, to report the height and body-mass index (BMI) of children and adolescents aged 5–19 years on the basis of rural and urban place of residence in 200 countries and ter

Global warming is one of the most important environmental issues from the last few decades and is causing climate change due to carbon dioxide (CO2) emissions and other greenhouse gases (GHG) emissions. Therefore, examination of atmospheric CO2 concentration (XCO2) variations on the local and global scale is critical. The purpose of this research was to analyze the role of environmental variables

Sialyl-Tn (STn or sialyl-Thomsen-nouveau) is a carbohydrate antigen expressed by more than 80% of human carcinomas. We here report a strategy for ratiometric STn detection and dual-color cancer cell labeling, particularly, by molecularly imprinted polymers (MIPs). Imprinting was based on spectroscopic studies of a urea-containing green-fluorescent monomer 1 and STn-Thr-Na (sodium salt of Neu5Acα2-

Background: The aim of this study was to evaluate the risk of gastric cancer associated with individual or combined glutathione S-transferases (GSTs) polymorphism and their interaction with environmental factors. Materials and Methods: Genotyping by PCR was carried out for 80 cases and controls each for GSTM1, GSTT1, and GSTP1 polymorphism and mapped for gene—environment association studies. The s

Aim of this contribution is to demonstrate how digital methods, in combination with traditional sources, can effectively contribute to reconstruct a narrative of the past based on a sensory account of a few coastal landscapes in Northwestern Etruria as they were perceived and described by ancient authors. A few passages by Strabo (Geogr. 5.2.5, 222C, Augustan period) and Rutilius Namatianus (de re

Juvenile idiopathic arthritis (JIA) is a heterogenous inflammatory joint disease and the most commonrheumatic disease in children. Oligoarticular JIA (oJIA) is the major subgroup, which mainly affects fewand large joints, such as the knee. The immunological processes and key players driving inflammationwithin the affected joints are not well characterised. Research has primarily focused on adaptiv

This article explores the musical performances, aesthetics, and multi-situated reception of the Indonesian electronic dance music in Europe and Indonesia, focusing on the duo Gabber Modus Operandi (GMO). Since their first international tour entitled “Trance Against the Machine” in 2019, the duo has gained significant attention, especially in Europe, because they are seen as part of a “seismic shif

This chapter examines the legislative and judicial dimensions of the digital rule of law in the EU and its current and future building. We argue that adjudication in EU law related to the digital rule of law is destined to grow as it is fostered by the new legislation in digitalisation and a proactive Court of Justice eager to interpret the rights enshrined under the Charter. The building of the d

The present study examines the discussions about alliance policy in the Swedish council of the realm 1680-1683. Taking issue with earlier research that has portrayed the Swedish foreign policy during this period in realist terms, the study instead uses the concepts of friendship, status and sovereignty to give context to the arguments used by the council when discussing alliance partners. Regardin

“Only in the most technical sense is this a case about who may penetrate whom where. At a practical and symbolical level it is about the status, moral citizenship and sense of self-worth of a significant section of the community.” Justice Albie Sachs, National Coalition for Gay and Lesbian Equality and Another v Minister of Justice and Others 1999 (1) SA 6, para. 107 More than 70 years after th

Digital literacy has become increasingly important. It's often linked to concepts like the information society, which we use to understand the complex changes in ways we socially and economically organize and run society today. The public library is faced with the task of ensuring that the professional skills of their workforce are in line with what is expected – and also interpreting what is

Hur kan man utforma det pianistiska lärandet hos pianoelever på kommunala musik- och kulturskolan? Frågan ligger centralt för denna uppsats med syftet att undersöka pianopedagogers syn på nödvändiga enheter för att uppnå balansen mellan musikaliskt uttryck och pianistiskt hantverk. I undersökningen framkommer pianopedagogernas grundtankar och strategier för ett helhetsutvecklande pianospel hos eleTitle: The pianistic learning at the Swedish Municipal School of Music and Culture – seeking balance between musical expression and piano technique. How is it possible to design the learning of piano to piano students at the Swedish municipal school of music and culture? This question is central for this paper with the purpose to study piano pedagogues’ thoughts on requisite components for achievi

Populärvetenskaplig sammanfattning: Klimatväxlingarna under sista istiden har alltid varit en debattfråga. Denna istids kallaste period inträffade för cirka 20.000 år sedan och benämns "istidsmaximum". Då var havsytan hundratjugo meter lägre än idag och det mesta vattnet var bundet i inlandsisarna. Klimatväxlingar försöker dagens kvartärgeologer att fastställa med en så bra tidsutlösningHigh-resolution analyses of sediments from two sites in Blekinge, south-eastern Sweden (the former Lake Togölen and Lake Bredsjön), were evaluated in order to establish the pollenstratigraphical position of the second and final drainage of the Baltic Ice Lake in relation to the Younger Dryas-Preboreal pollen zone transition. Remanent magnetisation and magnetic susceptibility were used to correlate

Den ryska invasionen av Ukraina har orsakat ofattbart mänskligt lidande och har destabiliserat den europeiska säkerhetsordningen. I gengäld har världsledare och internationella organisationer krävt att den ryska aggressionen beivras. Den rättsvetenskapliga debatten om lämpliga åtgärder för att säkerställa straffrättsligt ansvar för aggressionsbrottet har emellertid uppvisat stor oenighet bland forThe Russian invasion of Ukraine has brought immense suffering to the Ukrainian people and has destabilised the European security order. In response, world leaders and international organisations have called for the prosecution of the Russian aggression. However, the scholarly debate on the appropriate measures to ensure criminal accountability for the crime of aggression has demonstrated widesprea

This thesis argues that the escalating and protracted violence in Mexico, commonly known as the ‘war on drugs,’ constitutes a non-international armed conflict (NIAC) under international humanitarian law (IHL), calling for a formal application of this legal framework. Despite its devastating humanitarian consequences, the conflict is often mischaracterised within a law enforcement paradigm, contrib