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The contents of low-molecular-weight carbohydrates (LMWC; sorbitol, glucose, fructose and sucrose), starch, dietary fibre and organic acids were determined in seven apple cultivars at the start and end of the consumption interval. The cultivars included were Summered, Aroma, Ingrid Marie, Cox Orange, Mutzu, Belle de Boskoop and Jonagold. The total content of LMWG ranged between 615 and 716 g kg-1
Substitution of IgG in antibody deficiency or application of high-dose intravenous IgG (IVIg) in patients with autoimmunity are well-established treatments. Data on the mode of action of IVIg are, however, controversial and may differ for distinct diseases. In this study, we investigated the impact and molecular mechanism of high-dose IgG treatment in murine autoantibody-induced skin inflammation,
Urban densification is a way of accommodating population growth. Land adjacent to railways is used for constructing residences and other buildings, and new tramway systems are planned. Under these circumstances, nearby buildings will be exposed to vibrations and noise that may become a nuisance for the residents. It is necessary, even at an early stage of planning, to assess the extent of the vibr
The αβ T-cell coreceptor CD4 enhances immune responses more than 1 million-fold in some assays, and yet the affinity of CD4 for its ligand, peptide-major histocompatibility class II (pMHC II) on antigen-presenting cells, is so weak that it was previously unquantifiable. Here, we report that a soluble form of CD4 failed to bind detectably to pMHC II in surface plasmon resonance-based assays, establ
Current paper presents the results of investigating of multifunctional Ti-Si-N coatings. Ti-Si-N coatings have been deposited using CAVD method with the aim of studying their chemical, physical, structural and mechanical properties. Coatings of Ti-Si-N were modified by high-intensity ion implantation using copper ions with dose D = 2 × 1017 ions/cm2 and energy E = 60 keV. The results demonstrated
Background: The P1 antigen was first described in 1927 but not categorized with the Pk antigen in the P1PK histo-blood group system until 2010. Individuals of P1 phenotype have both the Pk and P1 antigens on their red blood cell (RBC) surface, while P2 individuals lack P1 and have lower amounts of Pk. Like in the ABO system, the antigens are carbohydrate epitopes built up stepwise by glycosyltrans
Inflammation is reported in post-traumatic stress disorder (PTSD). Few studies have investigated circulating blood cells that may contribute to inflammation. We assessed circulating platelets, white blood cells (WBC) and red blood cells (RBC) in PTSD and assessed their relationship to inflammation and symptom severity. One-hundred and sixty-three male combat-exposed veterans (82 PTSD, 81 non-PTSD)
Livestock manure is a valuable source of nutrients for crop production, but can also pose a public health hazard and have negative environmental impacts. This study investigated manure management practices among urban and peri-urban livestock keepers in Cambodia, to identify risk behaviours and socio-economic aspects associated with the handling of manure. A survey including 204 households was con
Objective: Postoperative ileus (POI), the most frequent complication after intestinal surgery, depends on dendritic cells (DCs) and macrophages. Here, we have investigated the mechanism that activates these cells and the contribution of the intestinal microbiota for POI induction.Design: POI was induced by manipulating the intestine of mice, which selectively lack DCs, monocytes or macrophages. Th
In this paper, we present a study for the identification of authors’ national variety of English in texts from social media. In data from Facebook and Twitter, information about the author’s social profile is annotated, and the national English variety (US, UK, AUS, CAN, NNS) that each author uses is attributed. We tested four feature types: formal linguistic features, POS features, lexicon-based
Packaging innovation is a strategic and valuable tool yet underexplored in business and extended value chains. Demographic changes, as population aging, and the increase of healthcare costs pose challenges and opportunities for the pharmaceutical industry, where packaging innovation offers new opportunities to provide patients with better solutions. This study employs a multi-stakeholder perspecti
The rapid development of new therapies in metastatic breast cancer (MBC), entails a need for improved prognostic and monitoring tools. Thymidine kinase 1 (TK1) is involved in DNA synthesis and its activity correlates to outcome in cancer patients. The aim of this study was to evaluate serum TK1 activity (sTK1) levels in MBC patients as a tool for prognostication and treatment monitoring. 142 women
Although natural products are an important source of drugs and drug leads, identification and validation of their target proteins have proven difficult. Here, we report the development of a systematic strategy for target identification and validation employing drug affinity responsive target stability (DARTS) and mass spectrometry imaging (MSI) without modifying or labeling natural compounds. Thro
The spatial patterns of precipitation regarding physiography and atmospheric circulations in the Lake Urmia Basin have been investigated. Daily rainfall time series for the 50 most reliable precipitation stations for the period 1980-2010 were analyzed to detect the regional precipitation pattern. To identify rainfall homogeneous regions, principal component analysis was applied to the precipitatio
Is there a universal hierarchy of the senses, such that some senses (e.g., vision) are more accessible to consciousness and linguistic description than others (e.g., smell)? The long-standing presumption in Western thought has been that vision and audition are more objective than the other senses, serving as the basis of knowledge and understanding, whereas touch, taste, and smell are crude and of
Introduction: The complement system is essential for an adequate immune response. Much attention has been given to the role of complement in disease. However, to better understand complement in pathology, it is crucial to first analyze this system under different physiological conditions. The aim of the present study was therefore to investigate the inter-individual variation in complement activit
In this contribution, we report about tomographic nanoscale imaging using a laser-produced plasma-based laboratory transmission X-ray microscope (LTXM) in the water window. The soft X-ray radiation of the LTXM is provided by a high average power laser-produced (1.3 kHz repetition rate, 0.5 ns pulse duration, 140 W average power) plasma source, a multilayer condenser mirror, an objective zone plate
BACKGROUND: The release of neuron-specific astroglial S-100 protein to the cerebrospinal fluid is a marker of cerebral damage. The aim of this study was to determine the pattern of release of S-100 protein to serum after pediatric cardiac operations and extracorporeal circulation.METHODS: Sequential blood samples from 97 children (up to 16 years) were taken after induction of anesthesia, immediate
