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Cytokines play a major role in lymphoid development. Defects of the common gamma chain (gamma (c)) or of the JAK3 protein in humans have been shown to result in a severe combined immune deficiency (SCID), with a profound defect in T and natural killer (NK)-cell development, whereas B-cell generation is apparently unaffected (T-B+NK- SCID). While extensive molecular and biochemical analysis of thes

Popular Abstract in Swedish Att vara äldre, beroende av hjälp och leva med varaktig smärta. För äldre människor som är beroende av hjälp från omvärlden för att klara av sitt dagliga liv, utgör inte bara den nedsatta funktion ett problem. Många är drabbade även av andra problem, varav ett vanligt är ihållande och varaktig smärta. För vissa äldre med gravt nedsatt funktion kan språket ha drabbat's This thesis explores everyday living with persistent pain from the perspectives of functionally dependent older persons in pain and of staff. A combination of qualitative and quantitative methods was chosen. Data were collected using interviews and tools for assessing pain. The first data collection included 66 persons (65+) living in sheltered accommodation and their corresponding contact nurses.

Induction of broadly neutralizing antibodies, such as the monoclonal antibodies IgGb12, 2F5 and 2G12, is the objective of most antibody-based HIV-1 vaccine undertakings. However, despite the relative conserved nature of epitopes targeted by these antibodies, mechanisms underlying the sensitivity of circulating HIV-1 variants to broadly neutralizing antibodies are not fully understood. Here we have

C1q deficiency is a rare condition associated with a systemic lupus erythematosus (SLE)-like syndrome and recurrent infections. Here we present the molecular basis behind C1q deficiency in three sisters of Inuit origin. Initial examination for complement deficiency showed no function of the classical complement activation pathway in the patients; the lectin and alternative pathways were intact. No

We have modelled the formation of the eccentric double-degenerate binaries J1141-6545 and B2303+46 using the Henyey-type full stellar evolution code STARS and the population synthesis code BSE. We find that the outcome depends strongly on the common envelope (CE) evolution efficiency parameter alpha(CE) and show that both systems can be modelled with a single value of alpha(CE). The final orbit of

This paper explores the concept of peer-to-peer learning (P2PL) in the context of North-European small-scale forest owners. The aim is to develop a framework for initiating new and evaluating already existing forest owners’ P2PL communities. Design: Previous studies of peer-learning are used to determine and justify eight dimensions for forest owners’ P2PL. To demonstrate and test the operability

Intracellular application of the sulfonylurea tolbutamide during whole-cell patch-clamp recordings stimulated exocytosis >5-fold when applied at a cytoplasmic Ca2+ concentration of 0.17 microM. This effect was not detectable in the complete absence of cytoplasmic Ca2+ and when exocytosis was elicited by guanosine 5'-O-(3-thiotriphosphate) (GTPgammaS). The stimulatory action could be antagonized by

Populärvetenskaplig sammanfattning: Då man för ner en elektrisk ström i marken kommer vissa material i marken laddas upp p.g.a. att positiva och negativa joner samlar ihop sig på ytor och i trånga porkanaler. Detta kallas för polarisering och kan användas för att bestämma t.ex. vad för typ av geologiska material som finns under markytan eller vart föroreningar i marken tar vägen. Fenomenet som uppIt has been shown that surveys of Induced polarization (IP) often contain data of low quality, because it is highly sensitive against different noise sources. When measuring induced polarization, where the method uses multicore cables and continuous electrode sounding (CVES, Continuous Vertical Electrical Sounding), noise phenomena such as capacitive coupling effects have to be considered. It is p

Populärvetenskaplig sammanfattning: Sedimentära facies och fauna från den sensiluriska Bjärsjölagårdkalkstenen i Skåne. Under den sena delen av silurperioden, för ca 420 miljoner år sedan, låg Sverige söder om ekvatorn och Skåne var täckt av ett grunt, varmt hav. I det här havet, den så kallade Baltiska bassängen, bildades sediment som vi idag återfinner bl.a. i ett gammalt övergivet kalkbrott i BThe late Ludlow Bjärsjölagård Limestone Member comprises a part of the Klinta Formation of the Öved-Ramsåsa Group in Skåne, southern Sweden. The ~25 m thick member was formed during the time of the globally known Lau Event and a major sea-level lowstand in the Baltic Basin. This study describes the sedimentary rocks, and their fossil fauna, of the Bjärsjölagård Limestone Member exposed in the Bjär

Denna uppsats behandlar fattigdomsbekämpning utifrån svensk biståndspolitik. Bi-ståndsgivning har länge varit en självklar del i både internationell och svensk politik, ändå har inga större framgångar skett med att utrota fattigdom. Syftet med uppsatsen är att utvärdera Sveriges politik om bistånd genom det senast utgivna dokumentet om bi-ståndspolitik – Biståndspolitisk plattform – utgiven av regThis essay concern poverty alleviation through Swedish aid policy. Giving aid has been an evident part of both international and Swedish policy for a long time, yet there has been no great success with eradicating poverty. The purpose is to evaluate Sweden’s aid policy through its most recently published document on aid policy, which the govern-ment published in March 2014. The document will be an

This research aims to explore how consumption impacts on the construction of affiliation boundaries within heterogeneous consumption-oriented subcultures. In order to accomplish this purpose, we have studied the growing phenomenon of barefoot running in relation to the consumption of minimalist footwear as a symbolic product. By doing so, we have explored how consumption vertebrates the subculture

I ett entreprenadavtal regleras det normalt huruvida det är beställaren eller entreprenören som ska bära ansvaret för att en entreprenad försenats. En situation som mer sällan regleras är vem av parterna som ska bära risken om det föreligger konkurrerande förseningsorsaker. Avsikten med förevarande framställning är därför att analysera hur en domstol skulle bedöma en entreprenörs krav på tidsförläNormally, the contract governing a construction project regulates whether the contractor or the employer shall bear the risk of a delay. Nevertheless, the parties rarely include in their contract provisions how liability for concurrent delays should be dealt with. Therefore, the purpose of this thesis is to examine how the Swedish courts would treat claims from a contractor for an extension of tim

Villa San Michele and Villa Lysis, formerly homes to Swedish doctor Axel Munthe and baron Jacques d’Adelswärd Fersen, now stand as two museums in Capri, Italy. The essay investigates their current state through a phenomenological tour, complying with Tonino Grifferos’s theory of a neo-phenomenological and philosophic “pathic aesthetic”. This theory argues for the presence of the beholder in their

Krita-paleogen-gränsen har länge varit central i diskussioner mellan forskare runt om i världen, då den markerar/sammanfaller med utdöendet av 75% av jordens arter till följd av ett enormt asteriodnedslag på Chicxulúbhalvön i Mexiko. Gränsintervallet är vida utbrett i sedimentära lagerföljder som bildades under denna tid, och kan identifieras genom sina unika kemiska egenskaper och karakteristiskaThe Cretaceous-Paleogene boundary has long been a center of discussion amongst scientists as it marks the extinction of 75% of all species on Earth. This mass extinction event was probably caused by an enormous asteroid impact event in what is now Mexico. The boundary interval is easily identified in the sedimentary geological record because of its unique chemical properties as well as its charact

Staters interventionism har legat bakom många grova människorättskränkningar. Eftersom FN-systemets vetorätt skyddar vissa stater från straffrättsligt ansvar finns det få reella utsikter för en minskning av dessa människorättsbrott. Inom det institutionella systemet är den Internationella Brottmålsdomstolen ICC och det möjliga aktiverandet av dess jurisdiktion över aggressionsbrottet – som nu befi