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Transgenic mice were generated expressing NK1.1, an NK cell-associated receptor, under control of the human CD2 promoter. Unexpectedly, one of the founder lines, Tg66, showed a marked defect in thymic development characterized by disorganized architecture and small size. Mapping of the transgene insertion by fluorescence in situ hybridization revealed integration in chromosome 2, band G. Already f
Intranasal administration of peptide Acl-9[4Y], based on the N-terminal epitope of myelin basic protein, can induce CD4(+) T cell tolerance, and suppress experimental autoimmune encephalomyelitis induction. The peptide-induced regulatory T (PI-T-Reg) cells failed to produce IL-2, but expressed IL-10 in response to Ag and could suppress naive T cell responses in vitro. Analysis of Jak-STAT signalin
Psoriasis is a frequently occurring inflammatory skin disease characterized by thickened erythematous skin that is covered with silvery scales. It is a complex genetic disease with both heritable and environmental factors contributing to onset and severity. The CD18 hypomorphic PL/J mouse reveals reduced expression of the common chain of beta(2) integrins (CD11/CD18) and spontaneously develops a s
The European Pre-Standard for protective clothing against cold ENV 342:1998 suggests that the testing of thermal insulation should be made on a moving thermal manikin. In this way the value can be used to match requirements specified by the IREQ-method or as realistic input for prediction of thermal stress in other standards. It is known from prior work that insulation values measured with human s
Popular Abstract in Swedish Humant immunbrist virus (HIV) bryter långsamt ner kroppens immunförsvar. Sjukdomen AIDS uppstår när den HIV infekterade personens immunförsvar är så pass försvagat att kroppen inte längre kan bekämpa infektioner som en frisk individ inte blir sjuk av. Världshälsoorganisationen, WHO, uppskattar att det idag lever omkring 40 miljoner människor i världen smittade med HIV. HIV-1 uses the coreceptors CCR5 and/or CXCR4 in addition to CD4 to enter the host cell. CCR5-using HIV-1 (R5 phenotype) appears to transmit infection and usually dominates the early stages of disease. Evolution of HIV-1 coreceptor use is usually described as the acquisition of CXCR4-using virus (X4 or R5X4 phenotype), and is linked to accelerated disease progression. However, the switch to CXCR4 u
The prevalence of Helicobacter pylori is high in Eastern Europe. The purpose of this study was to estimate the prevalence of H. pylori in symptomatic Lithuanian children and to identify the infection by clinicopathological and serological analyses. One hundred sixteen symptomatic children (age 8-16) with gastritis and duodenal ulcer were included. Biopsies were histologically assessed according to
In this study stool samples from dyspeptic patients and healthy subjects were used for detection of specific Helicobacter pylori antigens and DNA by immunoenzymatic test (PPHpSA) and semi-nested PCR (ureA-PCR), respectively. The H. pylori status was estimated by invasive endoscopy-based rapid urease test and histology or noninvasive urea breath test (UBT), and by serology (ELISA, Western blot). Th
Nanoparticles present enormous surface areas and are found to enhance the rate of protein fibrillation by decreasing the lag time for nucleation. Protein fibrillation is involved in many human diseases, including Alzheimer's, Creutzfeld-Jacob disease, and dialysis-related amyloidosis. Fibril formation occurs by nucleation-dependent kinetics, wherein formation of a critical nucleus is the key rate-
The number of discovered non-radially pulsating white dwarfs (WDs) in cataclysmic variables (CVs) is increasing rapidly by the aid of the Sloan Digital Sky Survey (SDSS). We performed photometric observations of two additional objects, SDSS J133941.11+484727.5 (SDSS 1339), independently discovered as a pulsator by Gansicke et al., and SDSS J151413.72+454911.9, which we identified as a CV/ZZ Ceti h
Gaia will observe huge numbers of binaries with a large range of periods. The present contribution tries to present some estimates of the expected number of detections and/or orbit determinations, based on simplified but large-scale simulations. The simulations have to model both a Galaxy with binaries, the instrument and observations, and the reduction programs. As in previous studies, there are
Air samples were collected on glass fibre filters in 22 animal houses and 3 hay storage barns and examined for the presence of bacterial endotoxin with the Limulus (LAL) test and the gas chromatography - tandem mass spectrometry (GC-MSMS) technique, based on detection of 3-hydroxy fatty acids (3-OH-FAs) as chemical markers of the endotoxin lipopolysaccharide. The median concentrations of airborne
Antibodies to citrulline-modified proteins have a high diagnostic value in rheumatoid arthritis (RA). However, their biological role in disease development is still unclear. To obtain insight into this question, a panel of mouse monoclonal antibodies was generated against a major triple helical collagen type II (CII) epitope (position 359-369; ARGLTGRPGDA) with or without arginines modified by cit
Premature prelabor rupture of the fetal membranes affects about 3% of pregnancies. The cause is usually infection, especially at earlier gestations. The prognosis and the risks of delivery are both much worse at earlier gestations. Before viable pregnancy, termination may be offered. Once the fetus is viable, steroids to mature the fetal lungs and antibiotics to reduce infection are the mainstays
A high non-specific binding of immunoglobulins to plastic surfaces was noted with a number of rat sera, when tested in an indirect 125I-labeled protein-A assay for detection of cell-surface-bound rat immunoglobulins of various classes and IgG subclasses. This type of non-specific binding was found with all types of Ig. The degree of binding varied with the type of test plate used and fluctuated wi
Neurotensin regulates both satiety and breast cancer growth in the experimental setting, but little is known about its role in the development of breast cancer or cardiometabolic disease in humans.
The αE integrin chain CD103 identifies a subset of migratory dendritic cells (DCs) in the gut, lung, and skin. To gain further understanding of the function of CD103(+) DCs in regulating adaptive immunity in vivo, we coupled ovalbumin (OVA) to the CD103 antibody M290 (M290.OVA). Intraperitoneal injection of M290.OVA induced OVA-specific CD8(+) and CD4(+) T-cell proliferation in lymph nodes (LNs) o
Background: Concurrent chemoradiotherapy is standard treatment for limited stage small-cell lung cancer (SCLC). Twice-daily thoracic radiotherapy of 45 Gy in 30 fractions is considered to be the most effective schedule. The aim of this study was to investigate whether high-dose, twice-daily thoracic radiotherapy of 60 Gy in 40 fractions improves survival. Methods: This open-label, randomised, phas
