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Background: Tamoxifen is an established treatment for breast cancer, but its long-term effects on survival and on secondary cancers are not fully evaluated. Material and methods: We studied 30 years outcome of 4124 postmenopausal patients who were randomized to receive (totally) two or five years of adjuvant tamoxifen. Results: After 5 years of follow-up, when tamoxifen treatment was finished in b

Antimicrobial peptides (AMPs), particularly host defense peptides (HDPs), have gained recognition for their role in host defense mechanisms, but they have also shown potential as a promising anticancer, antiviral, antiparasitic, antifungal and immunomodulatory agent. Research studies in recent years have shown HDPs play a crucial role in endothelial cell function and biology. The function of endot

Rysk-amerikanska Emma Goldman och kinesiska He-Yin Zhen kom från två olika delar av världen och var aktiva inom olika kunskapstraditioner och kulturer. Ändå var de båda anarkister som kämpade för kvinnlig frigörelse, och båda var de kritiska till de samtida rörelserna som stred för kvinnors politiska rättigheter. Det finns få studier som jämför tidig amerikansk feminism med tidig kinesisk feminismRussian-American Emma Goldman and Chinese He-Yin Zhen came from different parts of the world, and thus weren’t active within the same knowledge systems and cultures. However, they were both anarchists fighting for the liberation of women, and both were strongly criticising the contemporary women’s suffrage movements. Few comparisons have been made between early Chinese feminism and early American

Utveckling av en metod för att kartera högsta kustlinjen i Sverige med hjälp av brytlinjer extraherade från högupplösta höjdmodeller Högsta kustlinjens (HK) geografiska läge i landskapet markerar gränsen mellan subakvatiskt och supraakvatiskt avsatta sediment. Idag varierar HKs höjd över havet från några få m.ö.h. i Skåne till omkring 289 m.ö.h. i Ångermanland på grund av den glacialisostatiska lDevelopment of a method for mapping the highest coastline in Sweden using breaklines extracted from high resolution digital elevation models The geospatial position of the highest coastline (HCL) defines the boundary between subaquatic and supra-aquatic deposited sediments. Today the HCL is located at different elevations throughout Sweden, a few m.a.s.l. in southern Scania to around 289 m.a.s.l.

The perforated whole-cell configuration of the patch-clamp technique was applied to functionally identified beta-cells in intact mouse pancreatic islets to study the extent of cell coupling between adjacent beta-cells. Using a combination of current- and voltage-clamp recordings, the total gap junctional conductance between beta-cells in an islet was estimated to be 1.22 nS. The analysis of the cu

This paper is intended to give a short overview of the epidemiologic and experimental data on cancer risks associated with very low radiation absorbed doses. The paper will also discuss methods to present these data in an understandable way to those who are exposed e. g. in medical diagnostics and after a radiological or nuclear accident.

A linear quadratic control problem is considered, where several different controllers act as a team, but with access to different measurements. The state feedback solution obtained in a previous paper is here extended to output feedback and a separation principle is proved. The condition that certain measurements are unavailable to some state estimators is enforced by imposing a requirement that t

In this work, we present a novel method for non-invasive identification of liquids, for instance to allow for the detection of liquid explosives at airports or border controls. The approach is based on a nuclear magnetic resonance technique with an inhomogeneous magnetic field, forming estimates of the liquid's spin-spin relaxation time, T2, and diffusion constant, D, thereby allowing for a unique

This study is done within the framework of a project aimed at developing a wearable device (a bracelet) intended to support sensory motor rehabilitation of children with visual impairments. We present an exploratory study of aesthetic/hedonistic preferences for sounds and touch experiences among visually impaired children. The work is done in a participatory setting, and we have used mixed methods

A novel approach to background/foreground segmentation using an online EM algorithm is presented. The method models each layer as a Gaussian mixture, with local, per pixel, parameters for the background layer and global parameters for the foreground layer, utilising information from the entire scene when estimating the foreground. Additionally, the online EM algorithm uses a progressive learning r

A wireless body area network (WBAN) is a network of compact low power devices that are either wearable or implantable. A compact antenna with suitable radiation pattern and polarization is useful for WBAN applications. Ultra-Wideband (UWB) technology can be used in WBAN applications that require high data rates. This paper present a small wearable (15x17x17 mm) UWB antenna designed and optimized i

S100A4 and S100A9 proteins have been described as playing roles in the control of tumor growth and metastasis. We show here that a chemical probe, oxyclozanide (OX), selected for inhibiting the interaction between S100A9 and the receptor for advanced glycation end-products (RAGE) interacts with both S100A9 and S100A4. Furthermore, we show that S100A9 and S100A4 interact with RAGE and TLR4; interac

Gestational enterovirus (EV) infections have been associated with an increased risk for type 1 diabetes in the offspring. We therefore analyzed non-diabetic mothers for EV exposure in early pregnancy in relation to type 1 diabetes HLA-DQ risk genotypes and seroconversion to islet autoantibodies during pregnancy. Non-diabetic mothers who had islet autoantibodies (n=365) against glutamic acid decarb

Environmental factors, including viral infections, may explain an increasing and fluctuating incidence of childhood type 1 diabetes (T1D). Ljungan virus (LV) isolated from bank voles have been implicated, but it is unclear whether LV contributes to islet autoimmunity, progression to clinical onset, or both, of T1D. The aim was to test whether LV antibodies (LVAb) were related to HLA-DQ and islet a

Based on the Synchrotron Radiation (SR) beamline optical element-by-element alignment with analysis of the alignment results an optimized beamline alignment algorithm has been designed and developed. The alignment procedures have been designed and developed for the MAX-lab 1911-4 fixed energy beamline. It has been shown that the intermediate information received during the monochromator alignment

The paper identifies three interconnected scales of global politics in Artificial Intelligence (AI) and healthcare. It provides a multilevel framework for policy makers to situate hybrid-human AI collaborations in healthcare within broader global political concerns.

Work in developmental pragmatics has shown that even though infants display refined mindreading abilities, older children struggle to understand language phenomena that rely on mindreading. This apparent mismatch might be partially explained by considering children's growing sensitivity to social categories such as their interlocutor's age. Based on recent work in philosophy of mind, we investigat

Background: In this study we included patients with hereditary angioedema (HAE) caused by decreased levels of C1 inhibitor (HAE-C1INH). An increased risk of autoimmune disorders, particularly systemic lupus erythematosus (SLE), has been reported in HAE-C1INH. This suggests that complement consumption affects adaptive immunity. Objective: To investigate lymphocyte subpopulations in relation to dise