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A Hidden Markov Model (HMM) is used to improve the robustness to noise when tracking the atrial fibrillation (AF) frequency in the ECG. Each frequency interval corresponds to a state in the HMM. Following QRST cancellation, a sequence of observed states is obtained from the residual ECG, using the short time Fourier transform. Based on the observed state sequence, the Viterbi algorithm, which uses
BACKGROUND: The minor T allele of rs2943641 near the gene encoding for insulin receptor substrate 1 (IRS1) has been associated with decreased risk of type 2 diabetes (T2D) and adiposity in genome-wide association studies. Dietary intake can influence the regulation of IRS1, and studies have indicated sex-specific associations between IRS1 and adiposity. OBJECTIVE: The objective was to examine the
The mechanisms by which mycobacteria subvert the inflammatory defence to establish chronic infection remain an unresolved question in the pathogenesis of tuberculosis. Using primary epithelial cells, we have analysed mycobacteria induced epithelial signalling pathways from activation of TLRs to cytokine secretion. Mycobacterium bovis bacilli Calmette-Guerin induced phosphorylation of glycogen synt
This study describes how the serum protein histidine-rich glycoprotein (HRG) affects the complement system. We show that HRG binds strongly to several complement proteins: C1q, factor H and C4b-binding protein and that it is found complexed with these proteins in human sera and synovial fluids of rheumatoid arthritis patients. HRG also binds C8 and to a lesser extent mannose-binding lectin, C4 and
Background: Rhinovirus (RV)-induced chronic obstructive pulmonary disease (COPD) exacerbations exhibit TH(2)-like inflammation. We hypothesized that RV-infected bronchial epithelial cells (BEC) overproduce TH(2)-switching hub cytokine, thymic stromal lymphopoietin (TSLP) in COPD. Methods: Primary BEC from healthy (HBEC) and from COPD donors (COPD-BEC) were grown in 12-well plates, infected with RV
OBJECTIVES: We evaluated the prevalence and mechanism of poor responsiveness to clopidogrel and prasugrel in coronary artery disease patients with and without diabetes. BACKGROUND: Low platelet inhibition by clopidogrel is associated with ischemic clinical events. A higher 600-mg loading dose (LD) has been advocated to increase responsiveness to clopidogrel. METHODS: In this study, 110 aspirin-tre
This paper addresses the issue of gendered identity as presented in Charlotte Brontë's first and last novels, The Professor and Villette. As both of these novels are fictional autobiographies, and as the former is narrated by a man and the latter by a woman, they serve as good objects of analysis in that each of them represents its narrator’s understanding of him- or herself. Taking nineteenth
Studien har som syfte att studera hur dagens mark- och anläggningsarbeten, i en traditionell byggprocess, kan förändras mot en effektivare produktion med mål om att korta ledtider i de för markentreprenören ingående arbetsmomenten. Genom att ta vara på fördelarna och styrkorna med industriellt husbyggande avser studien att svara på till vilken grad anläggningsbyggande kan industrialiseras och i såThe purpose of the study is to investigate how today's excavation and foundation work, in a traditional construction process, can change towards a more efficient production with the aim of shortening lead times in the work performed by the contractor. By taking advantage of the benefits and strengths of industrial housing construction, the study intends to respond to if excavation and foundati
In an era of economic globalization shaped by hegemonic capitalism, resistance movements introduce different alternatives for a life beyond capitalism. The powerful and dominant system logic criticizes such movements for being utopian dreamers with no pragmatic sense of plausible social change. The 'ontology of the possible' for emancipatory social change is dominated by the coloniality of
Den svenska psykiatrins avinstitutionalisering innefattade visionen att stärka patienters autonomi. I klinisk vardag manifesteras detta bland annat genom en ökad förväntan på att patienter ska fatta aktiva beslut om den egna vården. Föreliggande enkätstudie syftade till att undersöka självskattad grad av autonomi bland patienter inom öppenvårdspsykiatrin i Skåne (n = 63). Vidare undersöktes sambanThe deinstitutionalization of Swedish psychiatry included a vision to strengthen patients’ autonomy. In clinical practice, this is manifested through increased expectations on patients to make active decisions about their own care. This study aimed to examine self-rated autonomy among psychiatric outpatients in Skåne (n = 63). Furthermore, the association between autonomy and functional impairment
An increasingly amount of parents choose to drive their children to the school. The tendency has increased to a point when schools parking areas is too congested which impairs road safety. When motorists no longer have any space to legally unload their kids, they park in unsuitable locations that significantly increase the risk of an accident. The increasing amount of car driving is not only creat
In this master´s thesis I seek to explore the concept of restorative justice, an ideological approach to justice which aims to repair the harm caused by crime through means of communication, cooperation, participation and restoration. By involving all parties affected by crime, restorative justice seeks to address crime through empowering victims, increasing community cohesion and making offenders
Bakgrund: Till följd av att den globala konkurrensen tilltar, ökar komplexiteten, flexibiliteten och produktvariationen inom produktion. Detta leder till att förbättringsprojekt blir allt svårare att genomföra. Händelsestyrd simulering har i litteraturen blivit identifierat som ett verktyg med förmågan att lösa dessa utmaningar, men till följd av att komplexiteten i en produktion ökar, växer ocksåBackground: Following a growing global competition, complexity, flexibility and product variability of manufacturing systems are increasing. This has led to improvement projects becoming more difficult to carry out. Discrete event simulation (DES) has in literature been identified as having the capability to solve these challenges, but as complexity of a manufacturing system increases so does also
The European project was founded on the advancement of liberal democracy where the rule of law and respect for human rights have a central place. In a period of ‘instability’ in the Union where organisational changes to national judiciaries have raised fears over rule of law backsliding among Member States threatening the functioning of the European Union’s legal order. It is necessary to facilita
INTRODUCTION: Patients with non-small cell lung cancer (NSCLC) faced an elevated risk for severe COVID-19 outcomes and were prioritized for early vaccination. However, immune responses to SARS-CoV-2 vaccines remain poorly characterized in this group, especially in patients receiving immune checkpoint inhibitor PD-1/PDL-1 (ICI) therapy.MATERIALS AND METHODS: In this prospective observational study,
Background: Derivatized celluloses, such as methylcellulose (MC) and hydroxypropyl methylcellulose (HPMC), are of pharmaceutical importance and extensively employed in tablet matrices. Each batch of derivatized cellulose is thoroughly characterized before utilized in tablet formulations as batch-to-batch differences can affect drug release. The substitution pattern of the derivatized cellulose pol
BACKGROUND: Early age at first full-term pregnancy and increasing parity are associated with a reduced risk of breast cancer. However, whether pregnancy decreases the risk of early-onset hereditary breast cancer is unknown. There is concern that pregnancy may increase breast-cancer risk in carriers of BRCA1 and BRCA2 germline mutations. We aimed to establish whether pregnancy is a risk factor for
Antineutrophil cytoplasm autoantibodies (ANCA) directed against bactericidal/permeability-increasing protein (BPI) are common in patients with cystic fibrosis (CF), and serum levels are correlated with lung colonization by Pseudomonas aeruginosa and the severity of lung damage. The production of BPI-ANCA may be due to the costimulation of BPI when mounting an immune response against P. aeruginosa.
