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Although CD4(+) memory T cells reside within secondary lymphoid tissue, the major reservoir of these cells is in the lamina propria of the intestine. In this study, we demonstrate that, in the absence of signals through both OX40 and CD30, CD4(+) T cells are comprehensively depleted from the lamina propria. Deficiency in either CD30 or OX40 alone reduced CD4(+) T cell numbers, however, in mice def

As home care increases and care is moving from nursing homes and hospitals into people’s homes, there are problem areas that need to be addressed and solved in a better way than today. Nurses and other home care workers are exposed to serval risks when the patients’ home environment becomes their workplace. There are also serval risks for the patients when their homes are transferred into “small h

Antimicrobial peptides produced by epithelial cells and neutrophils represent essential elements of innate immunity, and include the defensin and cathelicidin family of antimicrobial polypeptides. The human cathelicidin cationic antimicrobial protein-18 is an antimicrobial peptide precursor predominantly expressed in neutrophils, and its active peptide LL-37 is released from the precursor through

Objective: To assess mortality in patients with rheumatoid arthritis ( RA) treated with tumour necrosis factor (TNF) inhibitors, compared with a standard RA population. Methods: Patients were recruited from a regional register, which includes over 90% of patients with RA treated with TNF blockers in the area in 1999 or later, and a local community-based cohort of patients with RA, established in 1

Background & objectives: Human and animal cystatins have been shown to inhibit the replication of certain viruses and bacteria, though it is not directly demonstrated that the effects are due to protease inhibitory capacity of the cystatins. We report antibacterial properties of a novel antimicrobial peptidyl derivative, (2S)-2-(N-alpha-benzyloxycarbonyl-arginyl-leucylamido)-1-(E)-cinnamoyla m

Mouse models of asthma are now being used extensively in drug research. However, the successful unravelling of combinatorial interplays of cells and molecules in the murine airways may not be matched by equally successful demonstrations of an asthma-like pathophysiology. Here, Carl Persson, Jonas Erjefalt, Magnus Korsgren and Frank Sundler discuss the fact that major features of asthma may still n

Complement analysis in the clinic is usually associated with the quantification of C3 and C4, measurement of C1-inhibitor and screening for complement activity. These analyses have been available in routine diagnostic laboratories for decades. In recent years, however, the field of complement analysis has expanded considerably, with the introduction of novel assays to detect complement activation

Chemical shifts of protons can report on metabolic transformations such as the conversion of choline to phosphocholine. To follow such processes in vivo, magnetization can be enhanced by dynamic nuclear polarization (DNP). We have hyperpolarized in this manner nitrogen-15 spins in (15)N-labeled choline up to 3.3% by irradiating the 94 GHz electron spin resonance of admixed TEMPO nitroxide radicals

Optimization of islet transplantation protocols is necessary for improved success of treatment for type 1 diabetes. Here, we investigated whether the size of islets transplanted into the portal vein (PV) of the liver can affect engraftment in the early post-transplantation in an experimental mouse model. Small (average diameter < 250 mu m, group A) or large (average diameter > 250 mu m, group B) i

Popular Abstract in Swedish Ett grundantagande för avhandlingen Klassrummet som muntlig arena. Att bygga och etablera ethos är att en människa som med trovärdighet vill kunna verka som en demokratisk medborgare i olika kommunikationssituationer måste besitta kommunikativ kompetens. Följaktligen hänger demokrati och kommunikativ kompetens tätt samman. En viktig trovärdighetsfaktor i sammanhanget ärThe Class Room as an Oral Arena: Building and Establishing Ethos starts with the premise that every person who wants to act credibly as a democratic citizen must have a communicative competence. Democracy and communicative competence are closely linked. To communicate credibly is to communicate with ethos. The purpose of this dissertation is to study how students in Swedish gymnasium build and est

Color affects us both consciously and subconsciously, and can create actions and reactions: biological (colorful males to attract females in the animal world), psychological (the use of warm colors or cool colors to effect a specific mood), symbolic (specific colors for weddings and mourning), religious (blue, saffron), emotional (expressionism in art), social (pink and blue infant clothing) or pu

Carotenoid-based coloration in birds is widely considered an honest signal of individual condition, but the mechanisms responsible for condition dependency in such ornaments remain debated. Currently, the most common explanation for how carotenoid coloration serves as a reliable signal of condition is the resource trade-off hypothesis, which proposes that use of carotenoids for ornaments reduces t

We present new in-situ measurements of particle rotations and energy dissipation during compression of 3D packings of stiff, frictional particles. Two confined, uniaxial compression tests with different degrees of lateral confinement are discussed. X-ray computed tomography and 3D X-ray diffraction were combined to provide inter-particle forces, slip and roll distances, twist angles, and energy di

CONTEXT: Cardiometabolic multimorbidity (CM) is an increasing public health concern. Previous observational studies have suggested inverse associations between coffee, tea, and caffeine intake and risks of individual cardiometabolic diseases; however, their associations with CM and related biological markers are unknown.METHODS: This prospective study involved 172 315 (for caffeine analysis) and 1

This chapter discusses Article 114 TFEU as the choice of legal basis in the Digital Single Market. It argues that the EU’s competence in the internal market has developed into a default option for harmonising measures in digitalisation, exacerbated by the Union’s new regulatory approach. With particular reference to the area of competition law and the recently introduced Digital Markets Act, Artic