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Hematopoietic stem cell (HSC) numbers are tightly regulated and maintained in postnatal hematopoiesis. Extensive studies have supported a role of the cytokine tyrosine kinase receptor Kit in sustaining cycling HSCs when competing with wild-type HSCs posttransplantation, but not in maintenance of quiescent HSCs in steady state adult bone marrow. In this study, we investigated HSC regulation in Whit
På 1970-talet stämde en grupp samer den svenska staten då de ansåg sig ha bättre rätt till ett geografiskt område kallat Skattefjällen. Samer är av svenska staten erkända som ett ursprungsfolk, och som en minoritetsgrupp. Skattefjällsmålet togs upp av Högsta domstolen 1981 och resulterade i ett prejudikat som sedan dess haft stort inflytande på de flesta mål som berört samers rättigheter. Syftet In the 1970s a group of Sami people sued the Swedish State claiming a better right to a geographic area referred to as the Taxed Mountain (Skattefjällen). The Sami people are recognised as an indigenous people, and a minority group, by the Swedish State. The Taxed Mountain Case (Skattefjällsmålet), that reached the Supreme Court (Högsta domstolen) in the year of 1981, resulted in a precedent that
Urban establishment from scratch based on a smart city vision has been mainstreamed as a strategy to achieve urban sustainability goals. However, the smart city model itself has been criticized because of how the techno-centric solutions it uses could potentially lead to economic and social inequality. Urban Political Ecology (UPE) focuses on how the urban production process involve commodificatio
Denna utredning granskar hur proportionalitetsprincipen används i ett förarbete som föreslår straffskärpningar. Syftet är att problematisera huruvida proportionalitetsprincipen kan tillförsäkra enhetliga bedömningar av förhållandet mellan brott och straff på ett sätt som tillgodoser intresset av rättvisa bestraffningar och en begränsning av statens bestraffande makt. Utredningen granskar därför prThis thesis examines how the principle of proportionality is used in a law proposal that suggests increased penalties. It aims to problematize if the principle of proportionality can ensure stable assessments of the relationship between crime and punishment in a way that satisfies the interest of fair punishment and that limits the punitive power of the state. It is therefore interested in examini
I studien undersöks utmaningar och förbättringsförslag relaterade till arbetsmiljö, säkerhet och kommunikation inom byggindustrin för utländska arbetstagare, med extra fokus på länderna Polen och Litauen. Fri rörlighet för arbetstagare inom EU, som fastställs av artikel 45 i EUF-fördraget, möjliggör lika tillgång till både arbetsmöjligheter och behandling oavsett nationalitet. Syftet med studien The study examines challenges and improvement suggestions related to the work environment, safety, and communication within the construction industry for foreign workers, with a particular focus on Poland and Lithuania. The free movement of workers within the EU, as established by Article 45 of the treaty on the functioning of the European Union, ensures equal access to both employment opportuniti
The city of Milan stands today as a prominent model of sustainable urban development. Yet, beneath its allure lies a paradox: the quest for 'green' and 'smart' development has exacerbated privatization and fueled debates on green gentrification, social equity, and urban accessibility. This research explores the emerging impacts of large-scale green urbanization intervention in the
For further investigations in the field of artificial photosynthesis, a model compound, 1, has been developed to mimic the electron-transfer steps from the manganese cluster to P680+ in photosystem II. In this model compound the photosensitizer ruthenium(II)-trisbipyridyl was linked to a manganese(II) ion through a bridging ligand. Photoexcitation of 1 in the presence of the electron acceptor meth
OBJECTIVE - The efficacy and Safety of adding liraglutide (a glucagon-like peptide-1 receptor agonist) to Metformin were compared with addition of placebo or glimepiride to metformin in subjects previously treated With oral antidiabetes (OAD) therapy. RESEARCH DESIGN AND METHODS - In this 26-week, double-blind, double-dummy, placebo- and active-controlled, parallel-group trial, 1,091 subjects were
The ubiquitin-editing enzyme A20 (TNFAIP3) and the deubiquitinase CYLD are central negative regulators of NF-kappa B signaling. Both can act by removing nonproteolytic K63-linked polyubiquitin chains from an overlapping set of signaling molecules. In B cells, A20 deficiency results in hyperactivity, loss of immune homeostasis, inflammation, and autoimmunity. The reported consequences of CYLD defic
Learning from incidents is considered a very important source for learning and improving safety in the process industries. However, the effectiveness of learning from reported incidents can often be ques-tioned. Therefore, there is a need to be able to evaluate the effectiveness of learning from incidents, and for that purpose we need methods and tools. In this paper, a method is described for eva
"When we celebrate the days of our deceaced brothers" -- texts for the Office of the dead in Liber daticus vetustior
Popular Abstract in Swedish Ofrivilligt urinläckage, urininkontinens, omfattar mer än 50 miljoner människor i världen, varav cirka 500 000 i Sverige. Av dessa beräknas 2/3 vara kvinnor. Ofrivilligt urinläckage är ett medicinskt och socialt handikapp för den drabbade, operation och hjälpmedel förorsakar samhället stora kostnader. Risken för urininkontinens ökar med stigande ålder. I svenska studierAbstract Pelvic floor disorders (PFD) represent a major public health issue worldwide. Aims of this work Study I: to investigate associations between preoperative resting urethral parameters (MUCP, FL and CA) and objective outcome of laparoscopic colposuspension and, if possible, to identify cutoff values useful in clinical practice. Study II: to investigate a group of perimenopausal women reporti
OBJECTIVES: To develop and validate a recombinant vaccine to attenuate inflammation in arthritis by sustained neutralization of the anaphylatoxin C5a. METHODS: We constructed and expressed fusion protein of C5a and maltose binding protein. Efficacy of specific C5a neutralization was tested using the fusion protein as vaccine in three different arthritis mouse models: collagen induced arthritis (CI
We have combined experiments with atomic-scale molecular dynamics simulations to consider the influence of ethanol on a variety of lipid membrane properties. We first employed isothermal titration calorimetry together with the solvent-null method to study the partitioning of ethanol molecules into saturated and unsaturated membrane systems. The results show that ethanol partitioning is considerabl
Solens påverkan på klimatet är ett hett ämne i dagens klimatdebatt och utgör en av de största osäkerheterna i vår kunskap om klimatsystemet. Det finns flera sätt som förändringar i solaktivitet skulle kunna påverka klimatet på. En av de föreslagna länkarna mellan solaktivitet och klimat är att den galaktiska kosmiska strålningen (GCR) påverkar bildningen av låga moln. På grund av att låga moln harThe solar influence on climate is a hot topic in today’s climate debate and constitutes one of the largest uncertainties in our knowledge about the climate system. There are several ways in which solar activity changes could affect climate. One of the suggested links between solar activity and climate is an influence from galactic cosmic rays (GCR) on the formation of low clouds. Because of the ne
Syftet med denna studie är att undersöka fyra nutida pianopedagogers syn på hur Frédéric Chopins pianometodik har utvecklats från kompositörens tid fram till nutid. Litteraturen som används för denna studie fokuserar på Chopins tankar om undervisning, Chopin-spel under olika tider, samt traditionsöverföring. Studien baseras på personliga intervjuer och en kvalitativ metod. Data samlas in genom intTitle: "Clever, but not Chopinesque" - A study of four contemporary piano pedagogues’views on Frédéric Chopin’s piano method through the years The purpose of this study is to investigate four contemporary piano pedagogues’ views on how Frédéric Chopin’s pedagogical piano method has developed from the time of the composer to the present day. The literature used for this study focused on C
