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Recent three-dimensional, high-resolution simulations of neutron star coalescences are analysed to assess whether short gamma-ray bursts (GRBs) could originate from such encounters. The two most popular modes of energy extraction - namely the annihilation of and magnetohydrodynamic processes - are explored in order to investigate their viability in launching GRBs. We find that annihilation can pro
The organisational network of global environmental governance (GEG) mirrors the complexity of the planet's manifold and overlapping ecosystems. Bursting onto the international stage in the 1970s, environmental issues began to be addressed by a series of new international organisations, most of them affiliated with the United Nations. Some of them, such as the United Nations Environment Programme (
Popular Abstract in Swedish Cancer är en komplex och heterogen sjukdom där celler har börjat växa okontrollerat och denna sjukdom är idag ett stort hälsoproblem. På grund av diffusa symptom upptäcks cancern ofta i ett sent stadium. Otillräcklig kunskap om olika fenotyper hindrar utvecklingen av riktad behandling och patienter svarar därför väldigt olika på en given behandling. Denna avhandling ärCancer is a complex and heterogeneous disease where cells have started to grow uncontrolled and this disease remains a major health problem. Because of diffuse symptoms it often presents at a late stage. Insufficient understanding of the different phenotypes hinders the development of targeted therapeutics and consequently patients show a diverse range of responses to a given treatment. This thes
A general approach to derive summation rules in electromagnetics using Herglotz functions is presented in this paper. This approach is then used to obtain summation rules and bounds on partial wave scattering, which are illustrated numerically by the scattering of a Drude sphere.
Narratological studies have quite frequently focused upon linguistic structures, considered to be paradigmatic cases of narrativity, whereas pictorial signs (such as icons and symbols) or indices have received comparably much less attention. In this paper, however, I intend to outline some basic and regularly occurring narrative aspects of pictures and non-pictorial objects. As a point of departu
This paper examines the role of the photograph as vehicle for historic and virtual memory, in the remembrance culture of the Holocaust.
Popular Abstract in Swedish Inflammerat brosk i halsen. Rethosta eller andningsbesvär. Autoimmuna sjukdomar uppstår när immunförsvaret angriper och bryter ner den egna kroppens vävnader. Då kroppen infekteras av bakterier eller virus är immunförsvarets ökade aktivitet däremot en normal skyddsmekanism. Exempel på vanligt förekommande autoimmuna sjukdomar är diabetes, reumatoid artrit (RA) och multRelapsing polychondritis (RP) and rheumatoid arthritis (RA) are autoimmune diseases where an inappropriate immune response destroys cartilage. In RP, the ears, larynx, nose and joints are affected, while the most prominent sign of RA is arthritis. For ethical reasons many experiments can not be performed in man, and consequently animal models are needed. To investigate the complexity of the tissu
During B lymphocyte development, the transcriptional activity of the IgH locus is subject to spatial and temporal changes. The 3' enhancer (3'E) has been suggested to play an important role in regulation of immunoglobulin gene expression late in B cell development. We have investigated, using transgenic mice, the role of the 3'E in regulating Ig gene expression. Mice harbouring a rearranged IgH ge
Selected reaction monitoring (SRM) is a mass spectrometry method with documented ability to quantify proteins accurately and reproducibly using labeled reference peptides. However, the use of labeled reference peptides becomes impractical if large numbers of peptides are targeted and when high flexibility is desired when selecting peptides. We have developed a label-free quantitative SRM workflow
The aim of this article is to contribute to literature with new findings from biogenetics that are becoming increasingly important. In particular, we will discuss the new analytic frameworks that may open as a result of the incorporation of epigenetics in evolutionary economic thinking. This new approach is illustrated by studying the evolution of big Internet industry groups such as Apple, Google
We have cloned a cDNA for a myocardial cGMP-inhibited cAMP phosphodiesterase (cGI PDE) from a human heart cDNA library in lambda Zap II. The open reading frame [3.5 kilobases (kb)] of cDNA clone n.13.2 (7.7 kb) encodes a protein of 125 kDa. In Northern blots of total human ventricle RNA, a single mRNA species (8.3 kb) hybridized with a 4-kb EcoRI restriction fragment of clone n.13.2 cDNA (containi
This study addressed the contribution of ADAMTS13 deficiency to complement activation in thrombotic thrombocytopenic purpura (TTP). Renal tissue and blood samples were available from 12 TTP patients. C3 and C5b-9 deposition were demonstrated in the renal cortex of two TTP patients, by immunofluorescence and immunohistochemistry, respectively. C3 was also demonstrated in the glomeruli of Shiga toxi
Breast cancer type 1 susceptibility protein (BRCA1) has a multitude of functions that contribute to genome integrity and tumor suppression. Its participation in the repair of DNA double-strand breaks (DSBs) during homologous recombination (HR) is well recognized, whereas its involvement in the second major DSB repair pathway, nonhomologous end-joining (NHEJ), remains controversial. Here we have st
