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Hormone secretion from pancreatic islets is essential for glucose homeostasis and loss or dysfunction of islet cells is a hallmark of type 2 diabetes. Maf transcription factors are critical for establishing and maintaining adult endocrine cell function. However, during pancreas development, MafB is not only expressed in insulin- and glucagon-producing cells, but also Neurog3+ endocrine progenitor
Crises are a major driving force behind cooperation in the European Union. During severe crises, cooperation has been enlarged and intensified. The Ukrainian war and the covid-19 pandemic are two examples of this pattern, not least when it comes to the conduct of stabilization policies in the EU. In this chapter, we discuss the implications for the EU of a move towards increased fiscal federalism.
The effect of cimetidine on survival was investigated in 181 patients with gastric cancer. Immediately after operation or the decision not to operate, the patients were randomised in double-blind fashion to placebo or cimetidine 400 mg twice daily for two years or until death, with review every three months. Median survival in the cimetidine group was 450 days (range 1-1826) and in the placebo gro
In this third of a series of papers related to cataclysmic variables (CVs) and related objects, we analyse the population of CVs in a set of 12 globular cluster models evolved with the MOCCA Monte Carlo code, for two initial binary populations (IBPs), two choices of common-envelope phase (CEP) parameters, and three different models for the evolution of CVs and the treatment of angular momentum los
We very briefly discuss proposed in the literature possible scenarios for intermediate mass black holes formation in globular clusters. We also discuss the results of the MOCCA simulations of about 2000 models (BigSurvey) regarding the distribution of events connected with electromagnetic and gravitational radiations, namely: mass transfer on IMBH, collisions and mergers with IMBH and mergers with
Streptococcus pneumoniae (the pneumococcus) colonizes the human nasopharynx by forming multicellular biofilms. Due to the high level of asymptomatic carriage, transition to infections, such as otitis media, pneumonia, sepsis, and meningitis, occurs often enough that the pneumococcus remains a major cause of disease and death globally. Virus infection and virus-induced responses, such as increased
A methodology for studying change processes in working life combining computer-aided planning and cooperation in project groups is evaluated. The methodology is applied and studied in a planning workshop with representatives from manufacturing industries—managers, production engineers, supervisors as well as shop floor workers—and from health-and-safety agencies utilizing the methodology for plann
This chapter expands on three main topics. First, it is argued that the economic historical perspective may contribute to our understanding of present day development processes. Instead of advocating a one-size-fits-all model, an analytical framework is offered based on common traits from diverse examples. Second, the importance of agricultural change on the road towards sustained economic growth
Under the principle of freedom of contract, when two parties begin contract negotiations, they are under no obligation to actually arrive at an agreement and each one carries the risk for its own expenses and losses caused by the negotiations. However, even if the main rule says that each party bears the costs it might have incurred during the negotiations, if the parties do not reach an agreement
Case commentary | “Decision on the Apparent Conflict of Interests in relation to the Legal Representative of Victims a/0015/08...a/0035/08, Prosecutor v. Katanga and Ngudjolo Chui, Case No ICC-01/04–01/07, Pre-Trial Chamber I, 16 July 2008”
Popular Abstract in Swedish Utifrån epigrafiska källor analyserar avhandlingen Afrodites roll som ämbetsmannabeskyddarinna. Huvudmaterialet är 62 dedikationer till Afrodite: inskrifter från ämbetsmän eller dedikationer där gudinnan presenteras med ett epitet som alluderar på ett ämbete, t.ex. Afrodite Strategis, ‘Strategernas Afrodite’. Materialet visar att Afrodite dyrkades av ämbetsmän på ett paThrough the identification of a series of inscriptions, mainly datable to the Hellenistic era, a link between Aphrodite and the civic life and administration of the Greek poleis has come to light. The inscriptions in question are dedications to Aphrodite through which magistrates of various cities and varying status express their devotion to the goddess. In certain dedications, the goddess is even
Bandwidth is an important parameter in many metamaterial applications. It has been shown that Herglotz functions and sum rules offer a powerful methodology to analyze the trade-off between bandwidth and design parameters. Here, this approach is described for the temporal dispersion of constitutive relations and high-impedance surfaces.
