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The papilloma- and polyomaviruses are small DNA viruses that infect humans. Some members of these virus families can cause cancer in experimental animals and some are also established as carcinogenic to humans. Detection of specific antibodies to these viruses allows tracking past and present infections to elucidate natural history and association of infection with subsequent disease. As there are

Static light scattering (SLS) combined with structure-based Monte Carlo (MC) simulations provide new insights into mechanisms behind anisotropic, attractive protein interactions. A nonmonotonic behavior of the osmotic second virial coefficient as a function of ionic strength is here shown to originate from a few charged amino acids forming an electrostatic attractive patch, highly directional and

The Thomson multitaper estimator has become successful for spectrum analysis in many application areas. From the aspect of efficient implementation, the so called Welch or WOSA- Weighted Overlap Segment Averaging, has advantages. In the Welch estimator, the same, time-shifted, window is applied to the data-sequence. In this submission, the aim is to find a Welch estimator structure which has a sim

The role of infection in rheumatoid arthritis (RA) has not been determined. We aimed to document the infectious burden and some aspects of antibacterial immunity in a large and prospective cohort study of RA patients in the early and late stages of the disease and in their relatives predisposed to RA.

Small- and Medium-sized enterprises (SMEs) contributed a lot to the economic growth and promote employment in China. However, they were suffering from the credit discrimination, insecure property right protection, lack of the industry support policy and social services the same time. Based on this general background, in 2003, the Law of the PRC on promotion of Small and Medium-sized Enterprises (S

Background Anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) is a group of rare, autoimmune diseases causing inflammation in the vessel wall. Many organs can be affected, and kidney involvement is a common and serious manifestation. Complement activation is important in disease development and has also been detected in patients in remission. The reason for increased complemen

Background and Objectives Postanoxic electrographic status epilepticus (PSE) affects up to a third of all comatose patients after cardiac arrest (CA) and is associated with high mortality. Late PSE onset (>24 hours), from a restored continuous background pattern, and absence of established indicators of poor outcome at multimodal prognostication are described in survivors. We aimed to determine th

The incidence of melanoma is rising, increasing the need for efficient diagnostics. Excisional biopsy and histopathology remain the “gold standard” but often require multiple surgical incisions due to limitations in making a visual assessment of melanoma borders either by eye or using dermatoscopy. This challenge partly arises from the inability to non-invasively produce the necessary spectral con

Introduction Many studies have aimed at identifying additional prognostic tools to guide treatment choices and patient surveillance in lung cancer by assessing the expression of individual proteins through immunohistochemistry (IHC) or, more recently, through gene expression-based signatures. As a proof-of-concept, we used a multi-cohort, gene expression-based discovery and validation strategy to

Background: In a previous study, we explored real-world programmed death-ligand 1 (PD-L1) testing and treatment patterns for patients with advanced non-small cell lung cancer (NSCLC) in the era of immune-oncology. The present study aimed to investigate overall survival (OS) with PD-(L)1 inhibitors with longer-term follow-up in the Swedish setting. Materials and methods: Data were extracted from th

The increasing significance of social economy as a concept is linked to general global processes such as the crisis of the welfare state, neoliberal globalization, anti-bureaucracy tendencies and decentralization, but also to a growing political interest in human rights and social development. In Sweden the idea of the social economy generates wide support within civil society as well as within th

Even though there is a constant and accelerating growth of the aging population worldwide, such a rapid rise is negatively impacting available home and community services not able to encompass the necessities associated with the increased number of older people. In particular, there are increasing demands on e-health care services and smart technologies needed for frail elders with chronic disease

Globally, an enormous number of polluted areas are in need of remediation to prevent adverse effects on health and environment. In situ remediation and especially the monitoring thereof needs further development to avoid costly and hazardous shipments associated with excavation. The monitoring of in situ remediation actions needs easier and cheaper nondestructive methods for evaluation and verific