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Simulations of the absorption and fluorescence of indole in aqueous solution and at a nonpolar/polar interface

Theoretical results are presented on the absorption and fluorescence of indole in aqueous solution as well as at the air/water surface. We use a combined quantum chemical statistical mechanical model with explicit solvent. An approximate ab initio complete active space self-consistent field description of the indole molecule is used, coupled to a discrete polarizable water medium. From the bulk si

Mycophenolate mofetil, azathioprine and cyclophosphamide enhanced efficacy combined with cyclosporine in rat cardiac transplantation

Anti-proliferative drugs have been used for immunosuppression since the introduction of clinical transplantation. Most transplant centres include azathioprine (Aza) and cyclosporine (CyA) in their standard regimens, despite several controlled studies having failed to confirm the benefit of this combination. Aza is still. the most commonly used anti-proliferative drug, although no major differences

Transverse and longitudinal Bose-Einstein correlations

We show how a difference in the correlation length longitudinally and transversely, with respect to the jet axis in e+e− annihilation, arises naturally in a model for Bose-Einstein correlations based on the Lund string model. In genuine three-particle correlations the difference is even more apparent and they provide therefore a good probe for the longitudinal stretching of the string field. The c

Allergens as eukaryotic proteins lacking bacterial homologues

Only a small number of protein homologues cause the majority of allergies. There is no consensus structure or other obvious common denominator discriminating the few proteins that are allergens from thousands of other, non-allergenic proteins. By database sequence homology searching, we here show that to date known allergen sequences have no or few bacterial homologues, in contrast to randomly sel

Genome-Wide Expression Profiling and Mutagenesis Studies Reveal that Lipopolysaccharide Responsiveness Appears To Be Absolutely Dependent on TLR4 and MD-2 Expression and Is Dependent upon Intermolecular Ionic Interactions

Lipid A (a hexaacylated 1,4' bisphosphate) is a potent immune stimulant for TLR4/MD-2. Upon lipid A ligation, the TLR4/MD-2 complex dimerizes and initiates signal transduction. Historically, studies also suggested the existence of TLR4/MD-2-independent LPS signaling. In this article, we define the role of TLR4 and MD-2 in LPS signaling by using genome-wide expression profiling in TLR4- and MD-2-de

Escalation: Explorative studies of high-risk situations from the theoretical perspectives of complexity and joint cognitive systems

Popular Abstract in Swedish I högrisksystem såsom sjukvården är det frestande att härleda såväl framgång som motgång till enskilda individer. Vi prisar hjälten Dr. House för framgångssagor och vi drar syndabocken SOS-sköterskan inför domstol för att inte ha uppfattat allvaret i en specifik situation. Den enskildes professionalitet, erfarenhet och klokskap används som förklaringsmodeller för framgåThe main aim of the research is to explore different aspects of organisational resilience in escalating situations, with an investigation of both theoretical and practical implications. From the platform of an explorative approach, this study makes use of naturalistic research in the domain of health care and experimental simulation studies, in order to establish a broad theoretical framework vis-

Molecular Classification of Bladder Cancer

Popular Abstract in Swedish Cancer i urinblåsan är ett stort hälsoproblem i Sverige och världen. Det är den femte vanligaste cancerformen i Sverige och är den som belastar sjukvården med högst kostnader per patient. Ungefär tre fjärdedelar av de drabbade är män och patienterna är oftast kring 60-80 år gamla. Den behandling vi idag kan erbjuda en person som drabbas av blåscancer har inte förändratsDecisions in the treatment of bladder cancer today are based on clinical and pathological risk variables such as tumor stage and tumor grade. The importance of these conventional risk variables is well documented since more than 10 years, and they are used routinely in the clinics. Over the last ten years, cancer research has seen a gradual transition towards personalized medicine, i.e. the exploi

Influence of Ligand Substitution on Excited State Structural Dynamics in Cu(I) Bisphenanthroline Complexes

This study explores the influences of steric hindrance and excited state solvent ligation on the excited state dynamics of Cu(I) diimine complexes. Ultrafast excited state dynamics of Cu(I)bis(3,8-di(ethynyltrityl)-1,10-phenanthroline) [Cu(I)(detp)(2)](+) are measured using femtosecond transient absorption spectroscopy. The steady state electronic absorption spectra and measured lifetimes are comp

Requirements Trade-offs During UML Design

Designs almost always require trade-offs between competing design choices to meet pervasive system dependability requirements (e.g., security, performance and fault tolerance system goals). In some cases, dependability requirements are realized by functionality that cross-cuts designs. Aspect-Oriented Modeling (AOM) methods allow developers to localize such cross-cutting functionality in design mo

"Ge mig mitt beskärda bröd"

One of the Three learned societies at Lund University (Kungliga fysiografiska sällskapet)hosted on May 21, 2013 a symposium about food. My article gives theological perspectives on this issue.

Learning to Anticipate the Movements of Intermittently Occluded Objects

A model of event driven anticipatory learning is described and applied to a number of attention situations where one or several visual targets need to be tracked while being intermittently occluded. The model combines covert tracking of multiple targets with overt control of a single attention focus. The implemented system has been applied to both a simple scenario with a car that is occluded in a

Principles and nomenclature for the quantification of light

This chapter does not deal with any practical aspects of light measurement, only with theoretical concepts. The following concepts are explained: energy fluence , energy fluence rate, photon fluence, photon fluence rate and radiance, mol, as well as the following superflu-ous or obsolete terms and synonyms: actinic flux, space irradiance, scalar irradiance, spherical irradiance, vectorial irradian

Ultraviolet Spectral Analyses of HgMn Stars

Almost a decade after the last observations were performed by theInternational Ultraviolet Explorer (IUE) satellite its rich archivescomprise a wealth of opportunity for the stellar astronomer, inparticular when exploring large samples of stars. We have inaugurated anexploration into the nature of chemically peculiar stars through thoseelemental abundance studies which are best carried out at UVwa