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Unlike most ordered molecular systems, globular proteins exhibit a temperature of maximum stability, implying that the structure can be disrupted by cooling. This cold denaturation phenomenon is usually linked to the temperature-dependent hydrophobic driving force for protein folding. Yet, despite the key role played by protein−water interactions, hydration changes during cold denaturation have no
Background: Germline BRCA1 mutations confer a substantial lifetime risk of breast and ovarian cancer, but whether cancer at other sites is increased is less clear. To evaluate the risks of other cancers in BRCA1 mutation carriers, we conducted a cohort study of 11 847 individuals from 699 families segregating a BRCA1 mutation that were ascertained in 30 centers across Europe and North America. Met
We report the isolation and partial genetic characterization of two equine strains of granulocytic Ehrlichia of the genogroup Ehrlichia phagocytophila. Frozen whole-blood samples from two Swedish horses with laboratory-verified granulocytic ehrlichiosis were inoculated into HL-60 cell cultures. Granulocytic Ehrlichia was isolated and propagated from both horses. DNA extracts from the respective st
Biological processes often involve the surfaces of proteins, where the structural and dynamic properties of the aqueous solvent are modified. Information about the dynamics of protein hydration can be obtained by measuring the magnetic relaxation dispersion (MRD) of the water 2 H and 17 0 nuclei or by recording the nuclear Overhauser effect (NOE) between water and protein protons. Here, we use the
Synthesis of the antimicrobial protein neutrophil gelatinase-associated lipocalin (NGAL) increases dramatically in bronchial epithelial cells and alveolear type II pneumocytes during lung inflammation. IL-1beta induces a >10-fold up-regulation of NGAL expression in the type II pneumocyte-derived cell line A549 cells, whereas TNF-alpha, IL-6, and LPS had no effect. Similar IL-1beta selectivity was
Rapporten behandlar arbetsmiljön vid termisk ogräsbekämpning. Metoden innebär att ogräset hettas upp med hjälp av gaslågor. Både stora fordonsburna och mindre handdrivna används. Det som från arbetsmiljösynpunkt är speciellt med metoden är de risker som är förknippade med gasolanvändningen. De allvarligaste problemen med de aggregat som studerats har varit heta och oskyddade plåtar, heta avgaser o
In temperate regions, many vector-borne parasites maximise their transmission prospects by adjusting reproduction to seasonal cycles of host susceptibility and vector availability. Nevertheless, in these regions there are areas where environmental conditions are favourable throughout the year, so that parasites could benefit from a year-round transmission strategy. We analysed how different transm
Abstract in UndeterminedCytomegalovirus (CMV) causes severe sequelae in congenitally infected newborns and may cause life-threatening disease in immuno-deficient patients. Recent findings demonstrate the possibility to alleviate the disease by infusing intravenous immunoglobulin G (IgG) preparations, indicating that antibodies are an effective therapeutic option. Modern molecular methodologies, li
Phase behavior and structural features were investigated for "complex salts", consisting of the cationic hexadecyltrimethylammonium (CTA) surfactant with polyacrylate (PA(n), n = 30 or 6000) counterions, mixed with water and different n-alcohols (ethanol, butanol, hexanol, octanol, and decanol). The liquid crystalline structures formed were identified by small-angle X-ray scattering measurements,
Repeated exposure to certain low molecular weight (LMW) chemical compounds may result in development of allergic reactions in the skin or in the respiratory tract. In most cases, a certain LMW compound selectively sensitize the skin, giving rise to allergic contact dermatitis (ACD), or the respiratory tract, giving rise to occupational asthma (OA). To limit occurrence of allergic diseases, efforts
Primary immunodeficiency diseases (PIDs) comprise a heterogeneous group of disorders mainly characterized by increased susceptibility to infections. The aims of this study were to estimate the occurrence rate of PID in the paediatric (age ≤ 18 years) population of southern Sweden (approx. 265,000 children) and to describe their demographic, clinical and immunological characteristics. During a peri
LUND UNIVERSITY PO Box 117 221 00 Lund +46 46-222 00 00 Small-scale multilingualism and language contact in egalitarian foragers Yager, Joanne 2020 Document Version: Publisher's PDF, also known as Version of record Link to publication Citation for published version (APA): Yager, J. (2020). Small-scale multilingualism and language contact in egalitarian foragers. Lund University. General rights Cop
https://www.lu.se/sites/www.lu.se/files/Joanne_Yager_Full_PhD_Thesis.pdf - 2026-06-05
Brevmall Postadress Sölvegatan 37, 223 62 Lund Hämtställe 50 Besöksadress Ekologihuset, Sölvegatan 37 Telefon 046-222 0000 Fax 046-222 4206 E-post Centrum för mi l jö- och k l imat forskn ing Plan för jämställdhet, likabehandling och mångfald för Centrum för miljö- och klimatforskning Jämställdhets och likabehandlingsplan 2015-2016 Antagen av CEC styrelse 2015-05-06. Introduktion Centrum för miljö
https://www.cec.lu.se/sv/sites/cec.lu.se.sv/files/jamstalldhetsplan_2015-2016.pdf - 2026-06-05
State Aid is prohibited according to European Union legislation since it has possible distortive effects on competition. Nevertheless, Member States intervene in the economy and play an important role in the full functioning and development of the economy and society. The European Commission investigates potential State Aid measures by comparing the behaviour of the State with the behaviour of a h
The Swedish construction and real estate sector has a significant impact on the total national carbon dioxide emissions and energy consumption. Thus, energy efficient and environmentally friendly renovation measures of existing buildings in Sweden plays an important role in the attempt to mitigate the climate changes. By applying the methodology developed by the IEA EBC Annex 56, this study focuse
Uppsatsen syftar till att söka förståelse till varför tvister mellan fackförbund om vem som ska teckna kollektivavtal uppstår. Arbetsmarknadernas parter är i allmänhet ense om att det som regel bör finnas ett kollektivavtal på varje avtalsområde. Kollektivavtalets speciella rättsverkningar gör det viktigt för fackförbunden att vara avtalspart i ett kollektivavtal. Kollektivavtalet sätter i stor utThe aim of this essay is to seek understanding about why conflicts appear between trade unions regarding which one of them should sign the collective agreement in the workplace. The labour market parties are in general in an agreement that there should only be one applicable collective agreement in every area of work. The unique effects of the collective agreement make it crucial for the trade uni
Within a technology-driven company, product usability and interaction design is usually not the main focus. This thesis applies a Human-Centered design process with the aim of creating a more usable and intuitive product. The project is made in collaboration with Axis Communications who aims to expand its portfolio by transferring two intercoms from its subsidiary 2N Telekomunikace to its own asso
Narratives about Europe are stories of shared European past, present and future, that provide meaning to the existence of the European Union and to the policy it pursues. In this thesis, narratives about Europe are analysed in nine State of the Union speeches, given by Commission presidents from 2010 to 2020, and situated in the theoretical framework of discursive institutionalism. A combination o
