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Job 3:8-Cosmological Snake-Charming and Leviathanic Panic in a Near Eastern Setting

The author examines the intriguing mention of “those who curse Yamm” and “rouse Leviathan” in Job 3:8, and tries to relate these expressions to Near Eastern religious history. The old assumption that two texts inscribed on Aramaic incantation bowls indicate the full background of these expressions is challenged, and further evidence is sought in texts such as the Enuma Elish, the Gnosticizing “Hym

Plasma endostatin at intensive care admission is independently associated with acute kidney injury, dialysis, and mortality in COVID-19

BackgroundCritical COVID-19 is associated with high mortality, and acute kidney injury (AKI) is common. Endostatin has emerged as a promising prognostic biomarker for predicting AKI and mortality in intensive care. This study aimed to investigate plasma endostatin at intensive care unit (ICU) admission as a biomarker for AKI, renal replacement therapy (RRT), and 90-day mortality in COVID-19.Method

Impact of mild hypercapnia on renal function after out-of-hospital cardiac arrest

Background: Acute kidney injury (AKI) is a serious complication of out-of-hospital cardiac arrest (OHCA). Post-resuscitation cardiogenic shock (CS) is a key contributing factor. Targeting a higher arterial carbon dioxide tension may affect AKI after OHCA in patients with or without CS. Methods: Pre-planned exploratory study of a multi-national randomised trial comparing targeted mild hypercapnia o

Introduction

In this introduction, we explain how the chapters in this volume give support to the idea that different accounts of active cognition in the history of philosophy directly or indirectly respond to Aristotle’s account of cognition in his De anima.

Iberian Anarchism in Environmental History

In recent years, there has been a renewed interest in anarchism from both social movements and critical academic circles. When tracing the genealogy of anarchist perspectives since the nineteenth century, radical geographers have pointed out the importance of the anarchist movement in Spain, and particularly in the city of Barcelona. During the 1960s and 1970s, authors like Murray Bookchin shared

Stained DNA Dot Detection (SD3) : An automated tool for quantifying fluorescent features along single stretched DNA molecules

The main information in DNA is its four-letter sequence that builds up the genetic information and that is traditionally read using sequencing methodologies. DNA can, however, also carry other important information, such as epigenetic marks and DNA damage. This information has recently been visualized along single DNA molecules using fluorescent labels. Quantifying fluorescent labels along DNA is

Dialogue in the making : Emotional engagement with materials

Taking a psychological and philosophical outlook, we approach making as an embodied and embedded skill via the skilled artisan’s experience of having a corporeal, nonlinguistic dialogue with the material while working with it. We investigate the dynamic relation between maker and material through the lens of pottery as illustrated by wheel throwing, claiming that the experience of dialogue signals

Skäran i bäcken - En lösfyndsstudie om möjliga senneolitiska offerynd på ön Hven

This paper examines the possibility of identifying votive offerings among a collection of stray finds in a Late neolithic material from one farm land on the island Hven.First, I identify the Late neolithic artefacts in a collection of stray finds and make a register as well as take photographes of the artefacts. Then I compare these stray finds with material from hoards found in Scania to analyz i

REST selectively represses a subset of RE1-containing neuronal genes in mouse embryonic stem cells

REST is a transcriptional repressor that targets a group of neuronal genes in non-neuronal cells. In embryonic stem (ES) cells, REST has been implicated in controlling the expression of transcription factor genes that are crucial for lineage determination and for maintaining ES cell potential. Here, we asked whether REST directly regulates neural-specifying genes in mouse ES cells using siRNA-medi

Theoretical Predictions of Temperature-Induced Gelation in Aqueous Dispersions Containing PEO-Grafted Particles

In this work, we utilize classical polymer density functional theory (DFT) to study gelation in systems containing colloidal particles onto which polymers are grafted. The solution conditions are such that the corresponding bulk system displays a lower critical solution temperature (LCST). We specifically compare our predictions with experimental results by Shay et al. (J. Rheol. 2001, 45, 913-927

Role of p190RhoGAP in beta(2) integrin regulation of RhoA in human neutrophils

We found that engagement of beta (2) integrins on human neutrophils induced activation of RhoA, as indicated by the increased ratio of GTP:GTP + GDP recovered on RhoA and translocation of RhoA to a membrane fraction. The clustering of beta (2) integrins also induced a time-dependent increase in GDP bound to RhoA, which correlated with beta (2) integrin-induced activation of p190RhoGAP. The activat

CFD modelling of the thermo- and hydro-dynamic capabilities of long-necked plesiosaurs (reptilia, sauropterygia)

Plesiosaurs are secondarily aquatic reptiles with a fossil record that extends for over 140 million years, and their remains have been found in localities representing both warm, equatorial waters and cold, high-latitude environments. They are usually portrayed as a snake threaded through the body of a sea turtle. However, due to a general absence of preserved soft tissues, reconstructing the life

Urban air pollution disrupts placental microarchitecture and shifts hofbauer cells towards a pro-inflammatory state

Exposure to urban air pollution during early pregnancy is associated with increased risk for adverse pregnancy outcomes, such as preeclampsia (PE), and there is an urgent need to understand how air pollution affects biological mechanisms in the placenta. Hofbauer cells (HBCs) are fetal placental macrophages that regulate immune tolerance in the placenta. They are normally polarized towards an anti

A plasma protein profile of antidepressant response to omega-3 fatty acids

Background: Previous studies suggest an antidepressant effect of omega-3 fatty acids (n-3 PUFAs). This effect may be larger in patients with low-grade inflammation, defined as mild elevations of high sensitivity C-reactive protein or other commonly used inflammatory markers. The antidepressant mechanisms of n-3 PUFAs are not fully understood but may involve modulation of immunometabolic processes