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Topical corticosteroid phobia in atopic dermatitis : International feasibility study of the TOPICOP score

Background: Adherence to topical corticosteroids (TCS) is essential for the effective treatment of atopic dermatitis but can be limited by concerns about their use. This study examined the feasibility of applying the validated TOPICOP score for assessing TCS phobia across different countries. Methods: This was a prospective multicentre feasibility study conducted in 21 hospitals in 17 countries. P

Regionalized Development and Maintenance of the Intestinal Adaptive Immune Landscape

The intestinal immune system has the daunting task of protecting us from pathogenic insults while limiting inflammatory responses against the resident commensal microbiota and providing tolerance to food antigens. This role is particularly impressive when one considers the vast mucosal surface and changing landscape that the intestinal immune system must monitor. In this review, we highlight regio

Whole body heat balance and local insulation required to prevent extremity cooling in extremely cold environments

IntroductionLocal cooling in winter conditions is a sensitive and early warning of whole body cooling. Previous studies showed that the equilibrium temperature for the 5th finger is strongly affected by both temperature and insulation. The international standard ISO 11079 is used to calculate clothing insulation required for the whole body based on heat balance equations. However, it does not prov

Development and maintenance of nestling size hierarchies in the European starling (Sturnus vulgaris)

In this paper we show that nestling mass hierarchies in the European Starling (Sturnus vulgaris) are due to asynchronous hatching. The parents may, by starting to incubate the day the penultimate egg is laid, or earlier, affect the degree of hatching asynchrony and thereby the nestling weight hierarchy. Intra-clutch variation in egg size had no effect on nestling weight hierarchies, explaining onl

A Dutch book for group decision-making?

Distribute white and black hats in a dark room to a group of three rational players with each player having a fifty-fifty chance of receiving a hat of one colour or the other. Clearly, the chance that, as a result of this distribution, (A) "Not all hats are of the same colour" is 3/4. The light is switched on and all players can see the hats of the other persons, but not the colour of their own ha

Mergers of Authorities in Central Government: Role Ambiguities and Blame-Avoidance

Mergers of autonomous executive authorities in central government have become increasingly common, in particular in the Nordic countries. As compared to private sector mergers, the role of the principal (the central Government and its ministries) is more obscure in these mergers, this chapter argues. When problems arise in a merger, the ministry can take a step back and shift to a stakeholder posi

The language of eating and drinking: a window on Orang Asli meaning-making

We make in this chapter a first probe into the lexical domain of eating and drinking as it is construed in the Aslian languages, a branch of the Austroasiatic language family spoken by a majority of the Orang Asli of the Malay Peninsula. Fundamental to human experience and representation, the domain of ingestion has received increased linguistic attention in recent years. Setting out from our own

Lighting Recommendations in Operating Theatres

“The eyes lead the body.” A good visual environment is important for performance and wellbeing. Unsatisfactory visual conditions often induce a strained posture, more or less unconsciously, in an effort to improve vision. The requirements for the visual environment in an operating theatre are high. Surgeons or assistants who are having visual problems can induce treatment hazards. The purpose of t