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Prevention of superantigen induced down-regulation of T cell mediated cytotoxic activity by IL-2 in vivo. 1996 Accepted for publication in Immunology

Administration of staphylococcal enterotoxin A (SEA) to mice induces profound activation, cytokine production and cytotoxic activity of both CD4+ and CD8+ T cells, but subsequently activated cells are deleted or become anergic. This study demonstrates that administration of interleukin-2 (IL-2) can prevent sea-induced hyporesponsiveness in CD8+ cytotoxic T lymphocytes (CTL). Repeated injections wi

Familial risks in nervous-system tumours: a histology-specific analysis from Sweden and Norway

Background There are limited data available on tumour subtype-specific familial risks for nervous-system tumours. We aimed to provide such data at the population level. Methods We used data from the nationwide Swedish and Norwegian databases on familial cancer to calculate standardised incidence ratios (SIRS) for the familial risk of developing a nervous-system tumour in offspring born after 1931

A new method for normalized interpretation of antimicrobial resistance from disk test results for comparative purposes.

Objective To evaluate a calibration method for disk diffusion antibiotic susceptibility tests, using zone diameter values generated in the individual laboratory as the internal calibrator for combinations of antibiotic and bacterial species. Methods The high-zone side of zone histogram distributions was first analyzed by moving averages to determine the peak position of the susceptible population

The global burden of diabetic foot disease

Diabetic foot problems are common throughout the world, resulting in major economic consequences for the patients, their families, and society. Foot ulcers are more likely to be of neuropathic origin, and therefore eminently preventable, in developing countries, which will experience the greatest rise in the prevalence of type 2 diabetes in the next 20 years. People at greatest risk of ulceration

Calculating the soot particle size distribution function in turbulent diffusion flames using a sectional method

Soot formation in a turbulent jet diffusion flame is modeled using an unsteady flamelet approach in post-process. In the present work, we apply a detailed kinetic soot model with a sectional method, and study the evolution of the particle size distribution. Detailed information on the evolution of the soot particle size distribution function is acquired. It is found that the particle size distribu

Experiences of a User-Centred Research Approach involving Old People in Early Phases of Design; Reflections from Furniture Manufacturers

The paper concerns the furniture industry’s increased interest in opportunities and challenges to respond to demographic shifts and to meet future senior markets. A central issue discussed is how a user-centred approach in a collaborative design research project benefited the industrial partners. The paper focuses on the perspectives of the participating furniture manufacturers. The most involved

On the semantics and syntax of Scandinavian pronouns and object shift

In this article I argue that weak pronouns in the Scandinvian languages should be analysed as functional heads expressing pure phi-features, and that these heads occur either without complements or copying phi-features expressed in the rest of the extended projection. The description is modelled on a construction in Old and Modern Icelandic, where a pronoun may identify the phi-features of a delet

Systems Analysis of the Impacts of the Great East Japan Earthquake and Tsunami on Energy Supply System in Kamaishi-City

The Great East Japan earthquake and tsunami hit coastal cities in Iwate, Miyagi and Fukushima Prefectures of Tohoku Region devastating the energy supply system in the region. Electricity and fuel shortages caused severe problems in the city of Kamaishi varying from lack of mobility, communication, heating to reduced health conditions. This paper, aims to analyze the impacts of the earthquake and t

Protein hydration dynamics in solution: a critical survey

The properties of water in biological systems have been studied for well over a century by a wide range of physical techniques, but progress has been slow and erratic. Protein hydration-the perturbation of water structure and dynamics by the protein surface-has been a particularly rich source of controversy and confusion. Our aim here is to critically examine central concepts in the description of