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Few genome-wide association studies (GWAS) account for environmental exposures, like smoking, potentially impacting the overall trait variance when investigating the genetic contribution to obesity-related traits. Here, we use GWAS data from 51,080 current smokers and 190,178 nonsmokers (87% European descent) to identify loci influencing BMI and central adiposity, measured as waist circumference a

The photophysical properties of conjugated polymers (CPs) largely depend on the interactions between the CP and its environment. We present a study of two polymers with identical conjugated backbones, bare and insulated, that showed different fluorescence excitation modulation depth histograms. However, the polarization differences are not related to differences in conformation, as commonly believ

Transport through nanosystems is treated within the second-order von Neumann approach. This approach bridges the gap between rate equations which neglect level broadening and cotunneling, and the transmission formalism, which is essentially based on the single-particle picture thereby treating many-particle interactions oil an approximate level. Here we provide an alternative presentation of the m

This paper traces the intellectual effects of an encounter between Stig Kanger and Donald Davidson -two very different philosophers working in two seemingly unconnected areas. Their meeting in Oslo 1979 led the latter to improve his influential theory of radical interpretation and gave the former an inspiration for a rather striking paradox in preference logic. But, as we show, the paradox can be

In the Swedish crisis management system, the municipalities have a great responsibility. One part of this responsibility concerns preparing for crises by making risk and vulnerability analyses as well as plans for how to handle extraordinary events. Such preparedness planning involves municipal officials and consequently their conceptions of their organisations’ crisis management capabilities. Thi

This dissertation explores how the school subject Swedish is constructed for various groups of upper secondary school students and how the meeting between teacher and pupils is embodied in a range of Swedish subjects. The overall aim of the study is to illustrate why the teaching of Swedish in the classes under investigation takes place the way it does, as well as to discuss possible changes on a

Popular Abstract in Swedish Urinvägsinfektioner (UVI) är en av människans vanligaste bakteriella infektioner och drabbar både kvinnor och män. Kvinnor drabbas av UVI under hela sitt vuxna liv, medan UVI incidensen hos män ökar efter 40 – 50 års ålder pga. ökande problematik i urinvägarna med prostataförstoring, m.m. UVI orsakas av ett flertal olika bakteriearter, men tarmbakterien Escherichia coliUrinary tract infections (UTI) are among the most common human infections, and febrile UTI with bacteremia the most severe form. The relation between bacteria and host decides disease severity. The dominating uropathogen is Escherichia coli (E. coli). P fimbriae are the virulence factor of E. coli most clearly associated to severe disease. P fimbriated E. coli predominated in bacteremic febrile UT

The author sets out to analyse a number of representations of the biblical Hagar figure in African American and white American culture. Spivak (1988) has problematized the marginalization concept with regard to the study of the third world subject, arguing that knowledge always expresses the interests of the knowledge producers, and that Western academic research is always colonial. The aim of the

Molecularly imprinted polymers (MIPs) are man-made polymeric materials with molecular recognition abilities. The polymers mimic the molecular recognition of natural molecular recognition elements, such as receptors and antibodies, by binding target molecules in a highly selective manner. The interactions between MIPs and their targets are of non-covalent or covalent nature, or a mixture thereof. F

As distributed systems continue to evolve, automatic resource management is becoming more and more impor tant. The resource management system must be able to dynamically handle large heterogeneous systems in a way that gives good performanceand resource utilization. In the performance context, allocating software modules to nodes in an efficient way is of high interest. This paper considers the pr

A strategy for generating potential galectin inhibitors was devised based on derivatization at the C-3′ atom in 3′-amino-N-acetyllactosamine by using structural knowledge of the galectin carbohydrate recognition site. A collection of 12 compounds was prepared by N-acylations or N-sulfonylations. Hydrophobic tagging of the O-3 atom in the N-acetylglucosamine residue with a stearic ester allowed rap

Ex vivo lung perfusion (EVLP) is a novel procedure designed to rapidly assess and recondition unusable donor lungs for transplantation (LTx). EVLP may reduce graft immunogenicity and allorecognition via removal of passenger leukocytes. We aimed to explore this hypothesis using human EVLP and in vitro analysis.

In the upper airway, the production of antimicrobial peptides (AMPs) protects against bacteria, viruses and fungi. Previous investigations have revealed downregulated expression of AMPs in different manifestations of allergic disease. In this study, we examined the expression of LL-37, RNase7 and LEAP-2 in tonsillar tissue and studied a possible relation to seasonal allergic rhinitis (SAR).

The diagnosis of acute, non-traumatic diseases of the lower respiratory tract requires exact knowledge of the specific anatomy, physiology and pathology of the pediatric chest. The absolutely and relatively smaller airways, as compared with those of adults, and the undeveloped collateral ventilation result in radiological appearances that are unique in children. Viral pneumonia is predominant only

The SI-mediated carotenoid to BChl a energy-transfer pathway and carotenoid radical formation have been studied using femtosecond time-resolved transient absorption spectroscopy. A series of LH2 complexes (LH2 = light-harvesting complex 2) from Rhodobacter sphaeroides incorporating carotenoids neurosporene, spheroidene, and spheroidenone were used to explore the effect of conjugation length. The S

Objective: Oligoclonal bands (OBs) in electrophoresis of cerebrospinal fluid (CSF) are present in multiple sclerosis and here is investigated whether these also occur in experimental autoimmune encephalomyelitis (EAE). Material and methods: Experimental autoimmune encephalomyelitis was induced in 42 DA rats after immunization with rat spinal chord homogenate and the occurrence of OBs were detecte

Time-resolved absorption spectroscopy was used to study the femtosecond and picosecond time scale electron injection from the excited singlet and triplet states of Ru(dcbpY)(2)(NCS)(2) (RuN3) into titanium dioxide (TiO2) nanocrystalline particle film in acetonitrile. The fastest resolved time constant of similar to30 fs was shown to reflect a sum of two parallel ultrafast processes, nonergodic ele

Reactions of the triosmium cluster [HOs3(CO)(10)(eta(1):eta(1)-OC4H2CCH3)] with a series of aromatic aldehydes under mild conditions result in condensation of the ligand methyl group with the aldehyde C=O moiety to give typical aldol condensation products.