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Profilins are small, widely expressed actin binding proteins, thought to be key regulators of actin dynamics in living cells. So far, three profilin-genes have been described: profilin-I (PFN1), profilin-II (PFN2) with two splice variants and the recently identified profilin-III (PFN3). Here we describe the genomic organization of the genes encoding human and mouse profilin-III. Both are single ex

A previously presented robust and fast diagnostic NOx model was modified into a predictive model. This was done by using simple yet physically based models for fuel injection, ignition delay, premixed heat release rate and diffusion combustion heat release rate. The model can be used both for traditional high-temperature combustion and for high-EGR, low-temperature combustion. It was possible

Modern IC-engines produce more power per displaced volume and operate at higher combustion pressures and temperatures. In addition, engine structure materials such as aluminium and magnesium alloys, which are more sensitive to thermal loads, are more commonly used. These two parameters might lead to problems such as thermal fatigue, knock, high fuel consumption and emissions, performance loss, bor

Using a generic electromagnetic model based on the spherical vector harmonics, we provide the Cramer-Rao lower bound (CRB) for direction-on-arrival (DOA) and polarization estimation with arbitrary multiport antennas. By reciprocity, the receiving multiport antenna is characterized in terms of the transmission matrix from incident voltage waves to multipole coefficients of the outgoing spherical ve

A shift in business thinking from selling products to providing service solutions to customer needs is becoming noticeable. It is driven by increasing competition and the need to identify new profit centres for producers of mature products. This paper identifies a new product group that could be interesting from the product-service system perspective - baby prams. The study presents a new business

Objectives. The aims of the present study were to analyze patient- and management-related predictors for outcome after open (OR) and endovascular repair (EVAR) of ruptured abdominal aortic aneurysm (rAAA). Design. Retrospective study. Materials. The in-hospital registry of Malmo University Hospital identified 162 patients operated on due to rAAA between 2000 and 2004. Methods. Patient- and managem

Popular Abstract in Swedish Många olika proteiner kan produceras med hjälp av rekombinanta DNA tekniker. Ofta sätts vektorn som kodar för det rekombinanta proteinet in i bakterien E. coli, då den är välkänd. Det är viktigt att producera mycket celler för att uppnå hög produktivitet. Detta görs genom att näringsämnet (ofta glukos) tillsätts kontinuerligt till en så kallad semisats reaktor. TillsatsThe recombinant DNA techniques have made it possible to produce many different proteins for a wide range of applications. The vector encoding for the recombinant protein is often inserted in the bacterium E. coli as it is a well studied and a well-known organism. To achieve a high productivity, it is important to reach a high cell density. This is obtained through fed-batch operation where the nut

Vascular smooth muscle phenotype is regulated by environmental factors, such as mechanical forces, which exert effects on signaling to differentiation and growth. We used the mouse portal vein in organ culture to investigate stretch-dependent activation of Akt, extracellular regulated protein kinase (ERK) and focal adhesion kinase (FAK), which have been suggested to be involved in the regulation o

We present new synthetic broad-band photometric colors for late-type giants based on synthetic spectra calculated with the PHOENIX model atmosphere code. The grid covers effective temperatures T-eff = 3000... 5000 K, gravities log g = - 0.5... + 3.5, and metallicities [M/H] = + 0.5... - 4.0. We show that individual broad-band photometric colors are strongly affected by model parameters such as mol

This paper describes a methodology for measuring theological flow properties in-line, in real-time, based on simultaneous measurements of velocity profiles using an ultrasound velocity profiling (UVP) technique with pressure difference (PD) technology. The methodology allows measurements that are rapid, non-destructive and non-invasive and has several advantages over methods presented previously.

We examine the near-field optical properties of multilayered metal core-shell sphere nanostructures by extending the Mie theory, and demonstrate that the local-field enhancement can be increased by adding new metal shells. A local intensity enhancement of more than 10(5) times can be obtained in the cavity between the Ag core and the innermost Ag shell for proper configurations of multilayered Ag

Iterative numerical schemes for solving the electrostatic partial differential equation with variable conductivity, using fast and high-order accurate direct methods for preconditioning, are compared. Two integral method schemes of this type, based on previously suggested splittings of the equation, are proposed, analyzed, and implemented. The schemes are tested for large problems on a square. Par

Adaptive estimation of the linear coefficient vector in truncated expansions is considered for the purpose of modeling noisy, recurrent signals. Two different criteria are studied for block-wise processing of the signal: the mean square error (MSE) and the least squares (LS) error. The block LMS (BLMS) algorithm, being the solution of the steepest descent strategy for minimizing the MSE, is shown

The present study evaluated the combination of antithymocyte globulin (ATG) and cyclosporine A (CsA) in patients with low-risk myelodysplastic syndromes. Twenty patients (17 with refractory anemia and 3 with refractory anemia with excess blasts) received treatment with rabbit-ATG plus CsA. The overall response rate was 30% (6/20); three of the six responders had a complete response. The responses

Laser-induced fluorescence (LIF) has been developed for visualization of fuel distribution fields in an operating spark-ignition (SI) engine. Since the standard research fuel iso-octane, does not yield a useful LIF signal a fluorescent additive was used. None of the commonly used seeds were found adequate. A seed not commonly used in this context, 3-pentanone, C2H5COC2H5, was chosen due to favorab

Studying gene-lifestyle interaction may help to identify lifestyle factors that modify genetic susceptibility and uncover genetic loci exerting important subgroup effects. Adequately powered studies with prospective, unbiased, standardised assessment of key behavioural factors for gene-lifestyle studies are lacking. This case-cohort study aims to investigate how genetic and potentially modifiable