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Cellobiose dehydrogenase (CDH) is an emerging enzyme in the field of bioelectrocatalysis. Due to its flexible cytochrome domain, which acts as a built-in redox mediator, CDH is capable of direct electron transfer (DET) to electrode surfaces. This rare property is employed in mediatorless "third generation" biosensors. The ability of Corynascus thermophilus CDH to oxidize glucose under physiologica

Despite the huge increase in the number of management articles published during the three last decades, there is a serious shortage of high-impact research in management studies. We contend that a primary reason behind this paradoxical shortage is the near total dominance of incremental gap-spotting research in management. This domination is even more paradoxical as it is well known that gap-spott

‘Compensated dating’’ (CD) indicates the exchange of sexual intimacy for material compensation. This article investigates CD as receiving gifts for sex, such as luxuries, rent, travel, or monetary gifts. It proceeds by describing who engages in the practice and why, while comparing Russia with its cultural and linguistic neighbors, Ukraine and Belarus. A survey, which was answered by a representat

Red cell distribution width (RDW) has been associated with venous thromboembolism (VTE), but whether RDW is a predictor of first event of VTE is unknown. We investigated the association between RDW and incidence of first event of VTE in a population-based cohort.

Today, the majority of prostate tumours are detected at early stages with uncertain prognosis. Therefore, we set out to identify early predictive markers of prostate cancer with aggressive progression characteristics. We measured the expression of microRNAs (miRNA) using qRT-PCR in FFPE prostatic tissue samples from a Swedish cohort of 49 patients with prostate cancer and 25 without cancer and fou

The radiotherapy process is reviewed briefly and potential risks or pitfalls are identified. The focus is on modern advanced modalities in radiation therapy such as IMRT, VMAT, gating and tracking and also for the unknown to come. Existing methods, or quality controls (QC), or with better word barriers, are introduced at important steps of process with the purpose of prohibiting errors to continue

Autism spectrum disorder (ASD) is a common neurodevelopmental condition characterized by marked genetic heterogeneity. Recent studies of rare structural and sequence variants have identified hundreds of loci involved in ASD, but our knowledge of the overall genetic architecture and the underlying pathophysiological mechanisms remains incomplete. Glycine receptors (GlyRs) are ligand-gated chloride

The increasing use of digital tools in archaeology has vastly expanded our capacity to document and visualise the past, yet the reasoning that connects evidence to interpretation often remains implicit or undocumented. This paper addresses that gapby integrating Inference to the Best Explanation (IBE)—a philosophical model of hypothesis evaluation—into the Archaeological Interactive Report (AIR),

This study investigates the practical integration of Building Information Modelling (BIM) and Building Energy Modelling (BEM) for energy-efficient building design. This research explores the challenges and opportunities of openBIM-to-BEM workflows by drawing on a literature review and a real-world case study in Östergötland County, typical of the Million Programme, a large public housing initiativ

The aim of this study was to assess aquifer salinity risk by identifying high-risk land-use zones and proposing a new paradigm for groundwater resource management under salinization pressure. Salinity risk modeling was conducted with consideration of land-use patterns and agricultural production in the study region. The results revealed that approximately 26% of the aquifer lies within high-risk s

This work is devoted to the development and comprehensive validation of a new interatomic potential for bcc and hcp refractory alloys based on the Wsingle bondMosingle bondNbsingle bondTasingle bondZrsingle bondTi system. The presented model allows the simulation of various structural transformations, as well as the behavior of crystal defects in several of the phases observed in this system. The

BackgroundSome patients scheduled for cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC) only undergo explorative laparotomy (open/close procedure) due to extensive tumor spread or challenges in achieving complete cytoreduction (CC0). This study aimed to evaluate the surgical outcomes and overall survival in patients with peritoneal surface malignancy (PSM) who only

Biobased polyesters are emerging as sustainable alternatives for hot-melt adhesives (HMAs) owing to their tunable adhesion properties, facile processing, and versatile end-of-life options. Here, we report on the design of low-temperature (100 °C) HMAs, derived from oxygen-rich lignin-based copolyesters synthesized via copolymerization of a syringic acid-derived aromatic monomer with biobased aliph

Background: Joint pain and chronic back pain are highly prevalent in the aging population and have a large impact on life quality. As the underlying mechanisms are not fully understood, this exploratory cross-sectional study aimed to discover proteins and pathways associated with these two pain conditions in Swedish 70-year-old men. Methods: Plasma proteins (n = 720) were measured in participants

This paper explores an initiative by a local government in Rättvik, Sweden, to increase the consumption of local food in the municipal kitchens. It explores public procurement of local food as a way for local governments to address sustainability and climate goals while meeting residents’ demand for ‘good’ local food. Through a qualitative case study reviewing food and procurement policies across

Researchers have widely applied discharge simulation using artificial neural networks (ANNs) and have gained prominence in water resources. Morphological features, watershed urbanization, and climate change influence hydrological variables. Thus, data-driven models need to be able to identify the hydrological relationships without explicitly stating the physical processes. The main objectives of t

Self-care interventions for sexual and reproductive health (SRH), including HIV self-testing, self-injected contraception and self-managed abortion, offer promising pathways to advance universal health coverage, particularly in low- and middle-income countries. While often framed as cost-saving measures, this paper argues that self-care should be understood as a strategic investment in health syst