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In this study, a serial production system consisting of two machines and an intermediate finite buffer is considered. The machines have random processing times, and each machine contains one unit of a common critical component that is subject to random breakdown. Broken components must be replaced from an inventory of ready-for-use spare parts to restore machine functionality. This inventory is re
PurposeBlockchain technology (BCT) is a novel and disruptive innovation that can transform procurement processes in various industries, including the food sector. BCT can offer benefits such as transparency, traceability, security, and efficiency for procuring food products, which are essential for ensuring food security and quality. However, BCT faces several challenges that hinder its adoption a
Background Endoscopic papillectomy is a standard treatment for ampullary lesions, which are typically small and confined to the papillary mound. Laterally spreading lesions (LSLs) of the papilla of Vater are a rare ampullary lesion subtype involving extensive duodenal mucosa. Data on endoscopic papillectomy outcomes for LSLs are limited. This study compared endoscopic papillectomy for ampullary LS
The effects of the simultaneous presence of monopole and quadrupole pairing interactions on the fission barriers for heavy and superheavy elements are considered. The first barrier for light Thisotopes is found to be raised by 1 MeV, while heavier actinide nuclei seem to be less affected by the inclusion of quadrupole pairing. For the superheavy elements, the inclusion of quadrupole pairing tends
Ontological insecurity dominates the narratives of fear and anxiety that are perpetuated by populist and authoritarian regimes today. In these discourses and imaginings, specific ideas of ‘security’ are desired as a return to order or an imagined or idealized past. In this chapter, we focus on how those narratives regularly rely on gendered and colonial framings that are associated with weakness a
Although biologics have revolutionized psoriasis treatment, they pose a significant burden on the healthcare budget. With the wide range of biologics available and the increasing number of biosimilars, insights into the real-world cost per responder (CPR) are required. Therefore, this study aims to evaluate the real-world CPR of adalimumab, ustekinumab, IL17-and IL23-inhibitors, incorporating both
Degenerative diseases related to aging, such as malnutrition, memory loss, and osteoporosis, develop due to a lack of appropriate components required at certain times for protein synthesis. Alpha-ketoglutarate (AKG) is produced by the gut bacteriome and regulates several processes involved in protein metabolism, but mainly ensures the sparing of host nitrogen (amine group) and the synthesis of new
Analyzing kinetic experiments on protein aggregation using integrated rate laws has led to numerous advances in our understanding of the fundamental chemical mechanisms behind amyloidogenic disorders such as Alzheimer's and Parkinson's diseases. However, the description of biologically relevant processes may require rate equations that are too complex to solve using existing methods, hindering mec
The problem of evil is commonly regarded as one of the greatest intellectual obstacles to theistic faith. But this is on the assumption that faith requires belief. In contemporary analytical philosophy of religion, many question this assumption and argue that non-doxastic, or belief-less, faith is possible. In this paper, we consider how the evidential problem of evil affects non-doxastic faith. N
One of the best systems for exploring the origin of enzyme catalysis has been the reaction of ketosteroid isomerase (KSI). Studies of the binding of phenolates to KSI have been taken as proof that the electrostatic preorganization effect only makes a minor contribution to the binding of the real, multiring, transition state (TS). However, our simulation study has determined that the difference bet
In this article, I explore concerns that have been raised regarding the relation between love and uptake of reproductive technologies, embryo selection and enhancement. Objections to (certain) uses of these technologies in terms of fractures in love, either parental or between partners, come from a variety of directions, from the conservative to the liberal. I examine two claims: (1) that the sepa
Purpose: There is a need for a simple, non-invasive, and easily accessible 3D imaging technique for the anophthalmic socket to create imaging data for future 3D printing of prostheses. This study aimed to investigate the feasibility of using a novel handheld tomographic ultrasound for 3D mapping of the anophthalmic socket. Methods: Ten anophthalmic sockets were scanned using a tomographic ultrasou
This article seeks to propose a politics of landscape as a way to recognise emergent practices, methods and dramaturgies embedded in landscapes we inhabit. Being in and On Land/scapes means recognizing ways of making that challenge the means of domination, and to institute modes of doing and thinking that recognize dependencies. This article seeks to explore: What are the political implications an
The installation of a second RF cavity in the UVX electron storage ring at the Brazilian Synchrotron Light Laboratory (LNLS) at the end of 2003 brought about longitudinal instabilities driven by one of the HOMs of the new cavity. Even though the operational difficulties related to these unstable modes were successfully overcome by means of a combination of cavity tuning (using temperature and plun
BackgroundThe impact of season when determining a serum 25-hydroxyvitamin D (S-25OHD) cut-off level for optimal bone health is unknown.ObjectiveTo investigate the relative importance of S-25OHD for bone mineral density (BMD) by season.MethodsA subcohort of 5002 Swedish women (mean age 68 years), randomly selected from a large population-based longitudinal cohort study with repeat dietary and lifes
Precise diagnostic on the electron beam parameters is a very valuable tool and essential in the operation of synchrotron light sources. One possible option is to employ the emitted synchrotron radiation for non-destructive measurements. A tool, which has been used in many ring-based synchrotron light sources is Time-Correlated Single-Photon Counting (TCSPC). It allows to measure the arrival time d
