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Double Affinity Amplification of Galectin-Ligand Interactions through Arginine-Arene Interactions: Synthetic, Thermodynamic, and Computational Studies with Aromatic Diamido-Thiodigalactosides.

A series of aromatic mono- or diamido-thiodigalactoside derivatives were synthesized and studied as ligands for galectin-1, -3, -7, -8N terminal domain, and -9N terminal domain. The affinity determination in vitro with competitive fluorescence-polarization experiments and thermodynamic analysis by isothermal microcalorimetry provided a coherent picture of structural requirements for arginine-arene

An experimental study of effects of confinement ratio on swirl stabilized flame macrostructures

Swirl stabilized premixed flames are common in industrial gas turbines. The flame shape in the combustor is highly related to the combustion stability and the performance of the gas turbine. In the current paper, the effects of confinement on the time averaged flame structures or flame macrostructures are studied experimentally. Experiments are carried out with swirl number S = 0.66 in two cylindr

Riskanalys av modern arkitektur - Tillämpad på takterrasser

Risk analysis of modern architecture – applied to roof terraces Risk management is an important part of the construction process that more often is to be put behind the other parts of the process. Most of the construction companies are working with risk management in some way, but most likely in an informal way. The formal, more structured risk management requires a bigger effort from the people i

The Making of a Philosopher : The Contemplative Letters of Charles de Bovelles

Today the importance of epistolary networks for intellectuals in early modern Europe is well appreciated. Nevertheless, connections reaching outside the canon of celebrated humanists and scientists in the Republic of Letters are little studied. This article examines how Charles de Bovelles (1479-1567) used letters to establish a philosophical persona and publicize his contemplative approach to nat

Property Rights Control in the Data-Driven Economy : The Media Ecology of Blockchain Registries

The data-driven economy is fueled by massive amounts of information and other “intangible” expressions such as new technologies, photographic images, moving images, artworks, and texts. The materialities of the intangible economy reach far beyond cultural or technological inventions. For this reason, it is crucial to develop theories that manage to visualize the extent of property control over int

Inhibiting metabotropic glutamate receptor 5 after stroke restores brain function and connectivity

Stroke results in local neural disconnection and brain-wide neuronal network dysfunction leading to neurological deficits. Beyond the hyper-acute phase of ischemic stroke, there is no clinically-approved pharmacological treatment that alleviates sensorimotor impairments. Functional recovery after stroke involves the formation of new or alternative neuronal circuits including existing neural connec