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Differential homing mechanisms regulate regionalized effector CD8 alpha beta(+) T cell accumulation within the small intestine

The CC chemokine receptor (CCR)9 is expressed on the majority of small intestinal, but few colonic, T cells, whereas its ligand CCL25 is constitutively expressed by small intestinal epithelial cells. As such, CCR9/CCL25 have been proposed to play a central role in regulating small intestinal but not colonic immune responses and thus to organize regionalized immunity within the intestinal mucosa. H

Recognition molecules of the complement system: C1q and mannan-binding lectin in autoimmunity and immune defence

Popular Abstract in Swedish C1q, en delkomponent av C1 molekylen, och mannan-bindande protein (MBL) är igenkänningsmolekyler i komplementsystemet. De har likartad struktur. C1q binder till IgG och IgM och aktiverar den klassiska vägen. MBL binder till kolhydratstrukturer och aktiverar lektinvägen. Autoantikroppar mot C1q förekommer ofta vid svår systemisk lupus erythematosus (SLE) och förekommer oThe C1 subcomponent C1q and the mannan-binding lectin (MBL) are recognition proteins of the complement system, and have similar structure. C1q binds to IgG and IgM and activates the classical pathway. MBL binds to carbohydrate structures and activates the lectin pathway. Autoantibodies to C1q are frequently found in severe systemic lupus erythematosus (SLE) and are present in virtually all patient

Trafficking and forced labour : Filling in the gaps with the adoption of the supplementary ilo standards, 2014

Introduction On June 11, 2014, the International Labour Organization (ILO) adopted a new Protocol to its Forced Labour Convention, 1930 (No. 29) (ILO 1930), and a new Recommendation to supplement and develop both Convention No. 29 and the Protocol. These new ILO standards do not affect the definition of trafficking or the vital role of the UN Office on Drugs and Crime (UNODC) in leading the fight

Where is the 'global' in the European Union's Health Research and Innovation Agenda?

Global Health has not featured as prominently in the European Union (EU) research agenda in recent years as it did in the first decade of the new millennium, and participation of low-income and middle-income countries (LMICs) in EU health research has declined substantially. The Horizon Europe Research and Innovation Framework adopted by the European Parliament in April 2019 for the period 2021-20

Genetic Discrimination

In this article I discuss and analyse what is referred to as the standard account of discrimination as measured against a number of requirements any viable account of discrimination should satisfy. I also discuss how the standard account fails to explain how differential treatment based on genetic factors can be regarded as discriminatory.

A one step prediction error approach to the identification of viscoplastic material models

A new approach to the problem of estimating parameter in material models is presented. The approach is based on a state space representation of the constitutive equations and one step predictions. The differences between one-step predictions and the corresponding measurements are used to design generic one-step prediction error estimators, and in particular, the maximum likelihood method is presen

Photosynthetic Oxygen Evolution - EPR studies of the manganese cluster of photosystem II

Popular Abstract in Swedish Fotosyntesen är den mest grundläggande förutsättningen för människans överlevnad. Genom att absorbera solenergi och omvandla den till kemiskt bunden energi i form av energirika organiska molekyler, står fotosyntesen för nästan all tillförsel av energi till vårt ekosystem. Energin utnyttjas som mat, till oss och till djuren vi beror av, och som bränsle, fossilt eller färIn this thesis, a new electron paramagnetic resonance (EPR) signal from photosystem II is presented. The signal is shown to originate from the S0 oxidation state of the oxygen-evolving complex (OEC). It is a Mn-derived signal displaying clear hyperfine structure, centered at g=2, and is significantly broader than the well-known multiline signal from the S2 state, indicating the presence of MnII in

New insights into the dynamics of vacuum impregnation of plant tissues and its metabolic consequences.

The complex and highly interconnected intercellular air spaces of plant tissues occupied by gas or native liquid has offered the possibility for impregnation with a wide range of compounds. In food processing, the development of vacuum impregnation has allowed a controlled way to introduce these compounds to the tissue structure aiming at modifying structural, nutritional, and/or functional proper

Designing tax systems in Developing Countries - An evaluation of the Dominican tax system

The Dominican Republic is a small open economy, highly dependent on trade for its economic growth. During the past decades, the country has taken major steps to liberalize its trade regimes. As a consequence revenues from import duties and tariffs have fallen sharply. This has put an immediate pressure on the country to reform its tax system in order to increase revenue from domestic sources to co