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Implementing the Internet of Things (IoT) into business models has become an influential catalyst, supporting novel revenue generation, improved operational efficiencies, and competitive dominance. Still, its implementation has been challenged by barriers to technological, organizational, and societal dimensions. The current study utilizes the Fuzzy Decision-Making Trial and Evaluation Laboratory
BACKGROUND: Dementia with Lewy Bodies (DLB) is often misdiagnosed or conflated with Alzheimer's Disease (AD) due to overlapping clinical presentations and neuropathological features. The presence of AD-like features correlates with accelerated cognitive decline and a worse overall prognosis. Compared to AD, studies suggest that amyloid uptake in DLB may spare the occipital lobe. This project aims
Cells grow by acquiring external resources and transforming them internally, forming new cells as they divide. Metabolic networks focus on the flow of such resources within the cell as they undergo series of biochemical reactions. How population growth emerges from these complex dynamical networks remains unclear. Modeling the emergence of population growth, a central ecological concept, is thus e
Objectives: This is a protocol for a Cochrane Review (intervention). The objectives are as follows:. To assess the benefits and harms of pain and sedation management for screening or treatment of retinopathy of prematurity in preterm infants compared to placebo, no intervention, or other interventions.
Background: Childhood (< 20 years) nervous system tumors manifest in some rare cancer syndromes but how commonly they present with familial clustering between various histological types is not well known at a nation-wide level. Our aim is to enhance understanding of familial risks in childhood nervous system cancers. Methods: We used the Swedish population and cancer data from years 1958–2021 to a
This paper describes the development of a new variant of stereoselective strain-release driven reactions (formal homo [3 + 2] dipolar cycloadditions) which utilize housane (1) to construct functionalized amino alcohols and pyridine-substituted cyclopentanes in two to three steps from simple and easily available building blocks (nitrones and pyridine N-oxides respectively).
Quantifications of phytoplankton biomass and species composition are crucial for monitoring biodiversity and population dynamics in aquatic environments, and both direct microscopic counts and fluorescence-based methods have been widely used for monitoring. Recent advancements in DNA metabarcoding offer an alternative way of easily assessing diversity and species composition. However, a comprehens
Evolutionary changes in populations of microbes, such as microalgae, cannot be traced using conventional metabarcoding loci as they lack intraspecific resolution. Consequently, selection and competition processes among strains of the same species cannot be resolved without elaborate isolation, culturing, and genotyping efforts. Bamboozle, a new bioinformatic tool introduced here, scans the entire
Background/Objectives: Fertility-sparing surgery (FSS) is a standard practice for managing early stage cervical cancer, yet significant variation exists in clinical approaches worldwide. Our objective was to ascertain current practices and preferences for cerclage use among expert centers globally regarding FSS in patients with early stage cervical cancer. Methods: We conducted a cross-sectional s
Micro-scale mechanisms, such as inter-particle and particle-fluid interactions, govern the behaviour of granular systems. While particle-scale simulations provide detailed insights into these interactions, their computational cost is often prohibitive. At a recent Lorentz Center Workshop on “Machine Learning for Discrete Granular Media”, researchers explored how machine learning approaches can aid
The side-feeding patterns and the spectra of unresolved γ-lines are calculated for Gd, Dy and Er nuclei with neutron numbers from 82 to 86. Energies and configurations for states from the yrast line and approximately 2 MeV higher in energy are calculated as many-quasiparticle configurations in a deformed oblate potential. The γ-cascade is simulated by a Monte Carlo calculation. With a common avera
Vehicle models are often bound by non-disclosure agreements with manufacturers.This thesis presents a vehicle model based on vehicle data gathered for the NationalAdvanced Driving Simulator in Ohio and therefore it is not bound by such limitationsand can be used in future research projects.The development and validation of the vehicle model requires understanding of thesubsystems studied, componen
We are now seeing the development of a new generation of synchrotron radiation sources, the seeded, short-wavelength Free Electron Lasers (FELs), which are capable of driving the radiation to even higher intensities, and with new capabilities such as longitudinal coherence and ultra-short pulses. The Workshop on High-harmonic Seeding for Present and Future Short Wavelength Free-Electron Lasers, ho
Background: The aim was to investigate the noise and bias properties of quantitative 177Lu-SPECT with respect to the number of projection angles, and the number of subsets and iterations in the OS-EM reconstruction, for different total acquisition times. Methods: Experimental SPECT acquisition of six spheres in a NEMA body phantom filled with 177Lu was performed, using medium-energy collimators an
Background: Altered metabolism after liver surgery adds complexity topostoperative pain management. Opioids administered via intravenousPatient Controlled Analgesia (PCA) is one of the main alternatives forinitial pain management. Paracetamol is considered potentially dangerousafter liver surgery but used selectively. This study evaluates whether thereis a difference in patient outcome after hepat
Rapid and cost-effective retrieval of endogenous DNA from ancient specimens remains a limiting factor in palaeogenomic research. Many methods have been developed to increase ancient DNA yield, but modifications to existing protocols are often based on personal experience rather than systematic testing. Here, we present a new silica column-based extraction protocol, where optimizations were tested
COVID-19 is a severe respiratory disease affecting millions worldwide, causing significant morbidity and mortality. Adrenomedullin (bio-ADM) is a vasoactive hormone regulating the endothelial barrier and has been associated with COVID-19 mortality and other adverse events. This prospective cohort pilot study included 119 consecutive patients with verified SARS-CoV-2 infection admitted to two inten
Advancing the use of air-sensitive polar organometallic Grignard and organolithium reagents under more environmentally benign conditions, here we report the addition of these reagents to a-b unsaturated ketones and aldehydes using the deep eutetic solvent (DES) choline chloride (ChCl): glycerol (Gly) (1:2), under air. Reactions occur at room temperature within seconds with excellent regioselective
