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Background/objectives: A nationwide survey, covering all surgical departments, was conducted in a country with easily accessible tax-funded healthcare. The survey aimed to provide insight into ‘real-world’ intraductal papillary mucinous neoplasia (IPMN) surveillance, including the proportion of patients monitored, adherence to guidelines and details of follow-up. Methods: At all hospitals caring f

In Europe, azacitidine is the only hypomethylating agent approved for the treatment of patients with int-2-/high-risk myelodysplastic syndromes, offering significantly improved survival compared with conventional care. However, not all patients treated with azacitidine respond to treatment, and the vast majority of responders subsequently relapse. Currently, no standard care regimens have been est

This ethnographic study explores how Singaporean middle-class women who have opted out of the traditional labour market to support their children actively redefine their roles and responsibilities. How are investments of time, energy, emotional and economic resources in children’s education explained, and what bearing do they have on norms of motherhood? While involved or intensive parenting style

The vascular effects of endogenous substances can be eas- ily studied in the skin. Early in this century vasoregulation was shown to be dependent on innervation. Peptidergic trans- mitters have been shown to coexist and cotransmit along with noradrenalin and acetylcholine, sometimes being responsi- ble for non-adrenergic-non-cholinergic responses. This review summarizes recent information on vasor

Viral triggers at the intestinal mucosa can have multiple global effects on intestinal integrity, causing elevated intestinal barrier strength and relative protection from subsequent inflammatory bowel disease (IBD) induction in various models. As viruses can interfere with the intestinal immune system both directly and indirectly through commensal bacteria, cause-effect relationships are difficul

COVID-19 shocked health and economic systems leaving millions of people without employment and safety nets. The pandemic disproportionately affects people with substance use disorders (SUDs) due to the collision between SUDs and COVID-19. Comorbidities and risk environments for SUDs are likely risk factors for COVID-19. The pandemic, in turn, diminishes resources that people with SUD need for thei

BACKGROUND: The best management of hypertension in frail oldest-old (≥80 years of age) remains unclear and we still lack guidelines that provide specific recommendations. Our study aims to investigate guideline use in general practitioners (GPs) and to examine if guideline use relates to different decisions when managing hypertension in frail oldest-old. DESIGN/SETTING: Cross-sectional study among

Cities are key actors in reducing both the causes of climate change (mitigation) and its impact (adaptation), and many have developed separate mitigation and adaptation strategies and measures. However, in order to maximize outcomes, both scholars and practitioners are increasingly calling for more integrated and synergetic approaches. Unfortunately, related research remains scarce and fragmented,

The COVID-19 pandemic put a lot of strain on healthcare organizations. Nurses accountfor over 50% of healthcare staff, and how nurses perform in their work is influenced by a number ofhuman and work environmental factors. However, to our knowledge, there has not been a previousstudy with the intention to look at all areas that affect a sustainable working life and how theseimpact nurses’ mental we

Johannes of Rheinfelden’s treatise on card-playing, the Ludus cartularum moralisatus (“the moral meaning of card-playing”) is not only an important source of the history of plays and pastimes but also gives valuable information about late medieval thinking concerning the organization of human society. Johannes writes that the newly introduced cards were something of a revelation for him and that h

The developments and activities among the attendees to a Naqshbandi-Haqqani Sufi priory in north London in recent years have come to raise a number of issues regarding Sufism in Western Europe. The relationship between shaykh and murid, "disciple", has been developed into a complex interaction where ongoing negotiations concerning the content and form of the tariqa’s activities continuously take p