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In 2005, Pachon et al.1 proposed cardiac vagal denervation to treat neurally mediated syncope. Since then, a metanalysis of observational studies2 and a recent randomized controlled trial (RCT)3 have provided some evidence that cardioneuroablation (CNA) is able to prevent syncope recurrence at least during the first 2 years following the procedure in patients affected by reflex syncope. In brief,
To end the global tuberculosis (TB) epidemic and eliminate TB, countries around the world committed to significantly expanding the scope of their efforts, including rapid uptake of new tools, interventions, and strategies, and envisioned a world free of TB. Between 2010 and 2020, Ethiopia experienced a 5% average annual decline in TB incidence. However, at that current rate, ending the TB epidemic
The productivity of the Acetone Butanol Ethanol (ABE) fermentation can be significantly increased by application of various in situ product recovery (ISPR) techniques. There are numerous technically viable processes, but it is not clear which is the most economically viable in practice. There is little available information about the energy requirements and economics of ISPR for the ABE fermentati
Generalist plant-feeding insects are characterised by a broad host repertoire that can comprise several families or even different orders of plants. The genetic and physiological mechanisms underlying the use of such a wide host range are still not fully understood. Earlier studies indicate that the consumption of different host plants is associated with host-specific gene expression profiles. It
Young people have been prominent climate advocates globally and they are also becoming increasingly visible in global climate politics. They have participated in Conferences of the Parties (COPs) to the United Nations Framework Convention on Climate Change (UNFCCC) since COP1 in 1995. While recent studies have started to examine the representativeness and participation of youth at the COPs, we sti
Herbivores drive shifts in plant species composition by interacting with vegetation through defoliation, trampling and nutrient addition: urine and faeces. As herbivore effects on vegetation accumulate over time, they might spillover to other trophic levels, but how and when this happens is poorly understood. Since it is methodologically demanding to measure biodiversity across spatial gradients,
Background: The Duke criteria for diagnosing infective endocarditis (IE) were recently updated by the International Society for Cardiovascular Infectious Diseases (ISCVID) with the purpose of enhancing diagnostic specificity and sensitivity. This study investigated the performance of the Duke-ISCVID criteria in relation to previous criteria. Method: This retrospective single centre cohort study in
This is a protocol for a Cochrane Review (intervention). The objectives are as follows: To assess the benefits and harms of infant positioning, nesting, and swaddling for promoting development and preventing morbidity in preterm infants.
The global elimination of viral hepatitis by 2030 remains an ambitious goal that hinges not only on diagnostics and therapeutics but fundamentally on the strategic use and continued innovation of vaccines. The ESCMID Study Group for Viral Hepatitis (ESGVH) convened to examine the role of vaccination as the cornerstone of hepatitis prevention, from long-established immunisation programs to emerging
Background: Cognitive assessment for foreign-born individuals is suboptimal. The Multicultural Cognitive Examination (MCE) was developed for use in culturally, linguistically and educationally diverse populations. The MCE includes the Rowland Universal Dementia Assessment Scale (RUDAS) and performs assessment of memory, verbal fluency, and visuospatial function. Objective: To compare the psychomet
Due to large losses of seagrass meadows worldwide, restoration is proposed as a key strategy for increasing coastal resilience and recovery. The emergence of a seagrass meadow is expected to substantially amplify biodiversity and enhance benthic metabolism by increasing primary productivity and respiration. Nevertheless, open questions remain regarding the metabolic balance of aging seagrass meado
Despite a global consensus that fossil fuel subsidies should be reformed, limited progress has been made. The study assesses whether domestic political institutions insulating politicians from backlash and compensating those affected by reforms make subsidies easier to dismantle. It was found that proportional representation and corporatism were correlated with lower levels of fossil fuel subsidie
The ribosome is an essential drug target as many classes of clinically important antibiotics bind and inhibit its functional centers. The catalytic peptidyl transferase center (PTC) is targeted by the broadest array of inhibitors belonging to several chemical classes. One of the most abundant and clinically prevalent mechanisms of resistance to PTC-acting drugs is C8-methylation of the universally
In order to understand species’ sensitivity to habitat change, we must correctly determine if a species is associated with a habitat or not, and if it is associated, its degree of specialization for that habitat. However, definitions of species’ habitat association and specialization are often static, categorical classifications that coarsely define species as either habitat specialists or general
Background: Symptomatic osteoarthritis of the basal joint of the thumb (trapeziometacarpal joint) is a common disabling condition mainly affecting women. It is frequently treated with complete removal of the trapezium with or without soft-tissue interposition. There is limited evidence about whether removal of the trapezium affects stability of the wrist joint and increases the risk of developing
Real-time communication over Ethernet is becoming important in various application areas of cyber-physical systems such as industrial automation and control, avionics, and automotive networking. Since such applications are typically time critical, Ethernet technology has been enhanced to support time-driven communication through the IEEE 802.1 TSN standards. The performance and stability of contro
To assess the role of feral oilseed rape (OSR) plants as resources for pollinators and avenues for gene flow, we compared occurrence of feral populations in standardized agricultural landscapes, using a landscape ecological approach. The occurrence of feral and volunteer populations was investigated in relation to differences in road length and width, number of OSR fields, and landscape scale. The
