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This paper draws on Jean–Luc Marion's notion of non–objective phenomena to discuss the difficulty of studying leadership. Marion conceptualises non–objective phenomena as phenomena that cannot be captured by scientific methods. Attempts to do so result in a poor understanding of the phenomenon as it gives itself. Put differently: non–objective phenomena remain invisible to the gaze of the research

It has been known for more than a century that neoplastic cells often exhibit disturbances of the mitotic process, but the causes have only recently been thoroughly explored. In many cancers, a combination of cell cycle checkpoint deficiency and abnormal shortening of telomeres predisposes to unbalanced chromosome segregation at cell division and the development of complex genomic rearrangements.

Swedish children’s use of the headshake from 18 to 30 months shows a developmental progression from rote-learned coordination with speech to increasingly more flexible and productive coordination with speech. To deal with these observations, I introduce the concept of multimodal constructions in order to extend usage-based approaches to language learning and construction grammar into the kinetic d

Despite numerous studies documenting the association between cancer and venous thromboembolism (VTE), the reason for the excessive risk in certain cancers remains obscure. No large-scale studies have yet investigated the independent effects of cancer type, site and growth pattern. Between 1970 and 1982, 23,796 standardised autopsies were performed, representing 84% of all in-hospital deaths in an

The book contains the first part of an investigation aimed at finding out why it is morally wrong (at least prima facie) to cause species to go extinct. That it is morally wrong seems to be a very basic and widely held intuition. It seems reasonable that a moral theory worth taking seriously ought to be able to account for that intuition. The most common attempt to answer our question is to refer

Bmi1 was originally identified as a gene that contributes to the development of mouse lymphoma by inhibiting MYC-induced apoptosis through repression of Ink4a and Arf. It codes for the Polycomb group protein BMI-1 and acts primarily as a transcriptional repressor via chromatin modifications. Although it binds to a large number of genomic regions, the direct BMI-1 target genes described so far do n

We have studied the state of Cyt b559 and the Mn cluster by EPR and optical spectroscopy in the different S-states between pH 4.0-10.0. In these experiments, the pH was changed after the OEC turnover to the appropriate S-state (at pH 6.0) by 0-3 saturating flashes. Furthermore, the state of Cyt b559 after a subsequent flash given after the pH modification was also investigated. The results show th

Regarding access to remote sensing data, there are a number of aspects that need to be taken into consideration such as user time limit for e.g. space scientists, what rights do the involving states have, access rights for foreign domains and archiving. But the most central aspect is perhaps the pricing of such information. The demand for remote sensing data creates a competitive market, a market

Writing efficient parallel programs is the biggest challenge of the software industry for the foreseeable future. We are currently in a time when parallel computers are the norm, not the exception. Soon, parallel processors will be standard even in cell phones. Without drastic changes in hardware development, all software must be parallelized to its fullest extent. Parallelism can increase perfor

Cyclin-dependent kinase 2 (Cdk2) is dispensable for mitotic cell cycle progression and Cdk2 knockout mice are viable due to the compensatory functions of other Cdks. In order to assess the role of Cdk2 under limiting conditions, we used Skp2 knockout mice that exhibit increased levels of Cdk inhibitor, p27Kip1, which is able to inhibit Cdk2 and Cdk1. Knockdown of Cdk2 abrogated proliferation of Sk

A flying animal can minimize its energy consumption by choosing an optimal flight speed depending on the task at hand. Choice of flight speed can be predicted by modelling the aerodynamic power required for flight, and this tool has previously been used extensively in bird migration research. For insects, however, it is uncertain whether any of the commonly used power models are useful, as insects

Cathelicidins are a family of antibacterial and lipopolysaccharide-binding proteins. hCAP-18, the only human cathelicidin, is a major protein of the specific granules of human neutrophils. The plasma level of hCAP-18 is >20-fold higher than that of other specific granule proteins relative to their levels within circulating neutrophils. The aim of this study was to elucidate the background for this