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Huntington's disease (HD) is a fatal genetic neurodegenerative disorder. It has mainly been considered a movement disorder with cognitive symptoms and these features have been associated with pathology of the striatum and cerebral cortex. Importantly, individuals with the mutant huntingtin gene suffer from a spectrum of non-motor features often decades before the motor disorder manifests. These sy
Ultrashort laser pulses have become an indispensable tool in physics, chemistry and engineering. Their numerous applications call for accurate and robust characterization techniques able to reliably retrieve the pulse's intensity profile. Different methods, such as FROG [1] or SPIDER [2] and their variants, have been developed in past decades and are now common in many laboratories. More novel app
Measurements achieved with ptychographic imaging are a special case of diffraction measurements. They are generated by illuminating small parts of a sample with, e.g., a focused X-ray beam. By shifting the sample, a set of far-field diffraction patterns of the whole sample is then obtained. From a mathematical point of view those measurements are the squared modulus of the windowed Fourier transfo
This study presents the main features of the Swedish approach for resolving the banking crisis of 1991-93 by condensing them into seven policy lessons. These concern (1) the importance of political unity behind the resolution policy, (2) a government blanket guarantee of the financial obligations of the banking system, (3) swift policy action where acting early was more important than acting in e
Several experiments were conducted at the 10 MV Van-de-Graaff tandem accelerator at the Institute of Nuclear Physics, Cologne, to detect proton emission from the isomeric 6457-keV 10+ state in 54Ni. Excitation functions for two fusion–evaporation reactions were measured to maximise the population of the rare two-neutron evaporation channel from a 56Ni compound nucleus. The search for delayed proto
Brake-related particulate matter contributes considerably to the non-exhaust emissions of the transport sector in urban areas of the world. The airborne particle emissions from automotive brakes currently lack any proper regulations. Future regulations require test stands, test cycles and particle instruments to be suitable for measuring the brake emissions. This present work focuses on the design
OBJECTIVES: Infantile hemangiomas (IHs) are common; some cases require timely referral and treatment to prevent complications. We developed and validated a reliable instrument for timely and adequate referral of patients with IH to experts by nonexpert primary physicians. METHODS: In this multicenter, cross-sectional, observational study, we used a 3-stage process: (1) development of the Infantile
Fixed-target experiments using primary electron beams can be powerful discovery tools for light dark matter in the sub-GeV mass range. The Light Dark Matter eXperiment (LDMX) is designed to measure missing momentum in high-rate electron fixed-target reactions with beam energies of 4 GeV to 16 GeV. A prerequisite for achieving several important sensitivity milestones is the capability to efficientl
Many subjects have a negative spike in the beginning of a saccade in electro-oculographic signals. The amplitude of the spike depends on the location of the electrodes. The spike distorts the saccades and causes errors in the parameters. The saccade spike can assist in the identification of small saccades. A syntactic technique based on formal languages and parsing is presented which looks for spi
BACKGROUND: The immediate postoperative function of the parathyroid glands after surgery for primary hyperparathyroidism (pHPT) has not been established. We therefore examined the influences of hypercalcemia and hypocalcemia on serum parathyroid hormone (PTH) levels in the immediate postoperative period in patients with pHPT.METHODS: Ethylenediaminetetraacetic acid was infused in patients on the f
There are several different preventive measures that can be used to reduce the number of fire fatalities in residential buildings, but information on how effective different measures are for different groups are, however, lacking. As a result, general measures are often implemented on large portions of the total population, which is not as cost-effective as targeting certain measures for certain g
Scholarship on branding has made important contributions in terms of the value-creating function of branding. However, previous literature has overemphasized the creation of value for organizations at the expense of an understanding of the destructive side of branding for organizations and society. Drawing on the work of Boltanski and Thevénot, we theorize value as different in separate ‘worlds of
The development of cities is increasingly threatened by a worldwide water crisis. Urban water services (including drinking water, sanitation and drainage) are facing complex and multiple pressures, which are becoming increasingly frequent and severe. These pressures include floods, and the depletion, pollution and degradation of water resources and their associated ecosystems. These diverse pressu
In this paper, we shall be concerned with geometric functionals and excursion probabilities for some nonlinear transforms evaluated on Fourier components of spherical random fields. In particular, we consider both random spherical harmonics and their smoothed averages, which can be viewed as random wavelet coefficients in the continuous case. For such fields, we consider smoothed polynomial transf
The UN Charter describes him or her merely as the “chief administrative officer of the organization,” yet today the Secretary-General is widely recognized as the UN’s chief political representative. How did this transformation and expansion of the office from administrative to political take place? Existing scholarship tends to emphasize the contribution made by Dag Hammarskjöld. This article chal
Aims/hypothesis. Islet cell autoantibodies are a specific marker for Type 1 (insulin-dependent) diabetes mellitus. Standardisation of islet cell antibodies and the uniform reporting in International units is critical to research and the development of assays for islet cell autoantibodies as diagnostics. Methods. The suitability of a candidate serum to serve as the international standard for islet
