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Chronic myeloid leukemia (CML) is genetically characterized by the Philadelphia (Ph) chromosome, formed through a reciprocal translocation between chromosomes 9 and 22 and giving rise to the constitutively active tyrosine kinase P210 BCR/ABL1. Therapeutic strategies aiming for a cure of CML will require full eradication of Ph chromosome-positive (Ph(+)) CML stem cells. Here we used gene-expression

BACKGROUND: Previous research has provided evidence for cognitive dysfunction as a common symptom of systemic lupus erythematosus (SLE). In light of this, the primary goal of this study was to investigate how cognitive impairment in this patient group develops over time. In addition, the present dataset contributes to delineating the specific abilities that are impaired in SLE patients as well as

The human pathogen Streptococcus pyogenes causes substantial morbidity and mortality. It is unclear if antibodies developed after infections with this pathogen are opsonic and if they are strain specific or more broadly protective. Here, we quantified the opsonic-antibody response following invasive S. pyogenes infection. Four patients with S. pyogenes bacteremia between 2018 and 2020 at Skåne Uni

The MM500 meta-study aims to establish a knowledge basis of the tumor proteome to serve as a complement to genome and transcriptome studies. Somatic mutations and their effect on the transcriptome have been extensively characterized in melanoma. However, the effects of these genetic changes on the proteomic landscape and the impact on cellular processes in melanoma remain poorly understood. In thi

How is it that a group that self-identifies as “religious” and is associated with one of the most dramatic events in the United States during the 1980s could receive almost no attention from religious studies scholars? Furthermore, how is it that the court case in which said group was determined to not qualify as a “religion” has been discussed and challenged by legal scholars while being virtuall

Cognitive control is a skill used to control one’s own behaviour to reach a goal. We compared this skill across archosaurs by using the distraction task on American alligators, emus, chickens, and common ravens. We investigated whether the animals would still find a food reward hidden behind one of two identical opaque barriers after picking up a food distraction. Results show that all species can

A major component of aircraft noise is the jet noise created by the high velocity hot stream exhausting from a jet engine, interacting with itself and with the surrounding cold air. In the present paper the flow and acoustic fields that are generated by two coaxial jets are considered. Numerically, the problem is divided into a flow related part (Navier-Stokes system of equation) and an acoustic p

This paper presents a sensitivity analysis of unsteady-state SOFC-GT-HS operation based on two different characteristic maps of centrifugal compressor taken from open literature and scaled by the law of similitude to match the design point of the Hybrid System. The system layout under investigation is a pressurised type comprising a low and high temperature recuperator. Computations are based on a

Chronic myeloid leukemia (CML) is currently treated with tyrosine kinase inhibitors, but these do not effectively eliminate the CML stem cells. As a consequence, CML stem cells persist and cause relapse in most patients upon drug discontinuation. Furthermore, no effective therapy exists for the advanced stages of the disease. Interleukin-1 receptor accessory protein (IL1RAP; IL1R3) is a coreceptor

Purpose: Enterolactone (ENL) is formed in the human gut after consumption of lignans, has estrogenic properties, and has been associated with risk of prostate cancer. We examined the association between plasma ENL levels and prostate cancer in a nested case–control study within the population-based Malmö Diet and Cancer cohort. We also examined the association between plasma ENL and dietary and li

I Skåne står industrisektorn för omkring 26% av energianvändningen, och producerar samtidigt betydande mängder spillvärme. Det pågår kontinuerligt ett utvecklingsarbete och det finns redan många lyckade exempel på återvinning av industriell restvärme, men det finns fortfarande potential till förbättring. Som fallstudie har en medelstor kemisk tillverkningsindustri, som huvudsakligen producerar vat

Mikrofluidisk separation och en-cell fångst av röda blodkroppar Populärvetenskaplig Sammanfattning av Examensuppsats, Oskar Ström Varje år dör en halv miljon människor av malaria 1. Invasionen in i röda blodkroppar av malariaparasiter efter en malariainfektion är central för sjukdomens utveckling. För att kunna studera invasionen har mikroskopiska fällor utvecklats och använts för att fånga in röThere have been several studies which indicate a preferential invasion towards younger red blood cells (RBCs) for the malarial parasite, P. Falciparum. Knowledge about a preferential mechanism could aid in the development of novel anti-malarial drugs. While the preference in these reports has been studied with density-separation of red blood cells, separating the cells by deformability may be a mo

Bakgrund: Hälsoläget och dödligheten bland schizofrena patienter är i jämförelse med normalpopulationen klart försämrad. Patientgruppen dör i genomsnitt 10-20 år tidigare och kardiovaskulära sjukdomar (CVD) är särskilt utmärkande. Patientgruppen lever stillasittande liv i högre utsträckning, men fysisk aktivitet, fysisk träning och ökad fysisk fitness har i flera studier visat sig ha goda hälsoeff

Neutrophil extracellular traps (NETs) are structures that neutrophils form in response to various stimuli, including invading pathogens. NETs are increasingly studied, and their importance has been demonstrated in autoimmunity and infection. However, no consensus has emerged on their quantification, with many studies resorting to manually counting NETs in microscopy images. NETQUANT is a free soft

The development of immersive visuoauditory media brings to the fore several design challenges concerning cognitive human factors, such as visual perception, embodied interaction, and emotional engagement. With a focus on visual perception, our research emphasises a systematic study of embodied multimodal interaction in immersive settings and provides a cognitive model of visuospatial complexity th

Canadian mega-mining in Central Mexico: Ecologically Unequal Exchange, Violence and Organized resistance 1992-2016 Degree of Master of Science (Two Years) in Human Ecology: Culture, Power and Sustainability 30 ECTS CPS: International Master’s Programme in Human Ecology Human Ecology Division Department of Human Geography Faculty of Social Sciences Lund University Author: Ingrid Altamirano Supervis

https://www.keg.lu.se/sites/keg.lu.se/files/cps_master_thesis._ingrid_a._sin_intro.pdf - 2026-05-14

Canadian mega-mining in Central Mexico: Ecologically Unequal Exchange, Violence and Organized resistance 1992-2016 Degree of Master of Science (Two Years) in Human Ecology: Culture, Power and Sustainability 30 ECTS CPS: International Master’s Programme in Human Ecology Human Ecology Division Department of Human Geography Faculty of Social Sciences Lund University Author: Ingrid Altamirano Supervis

https://www.keg.lu.se/sites/keg.lu.se/files/cps_master_thesis._ingrid_altamirano_2017.pdf - 2026-05-14