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Occupational sedentariness and breast cancer risk

Background: Epidemiological studies have indicated that physical activity reduces the risk of developing breast cancer. More recently, sedentary behavior has been suggested as a risk factor independent of physical activity level. The purpose of the present study was to investigate occupational sedentariness and breast cancer risk in pre- and postmenopausal women. Materials and methods: In a popula

The absence of aldehyde dehydrogenase 1 A1-positive cells in benign mammary stroma is associated with risk factors for breast cancer

In this study, aldehyde dehydrogenase 1 (ALDH1)-expressing cells in stroma of histologically normal breast tissue from premenopausal women were investigated in situ regarding cellular morphology, cell distribution, and relation to the additional stem cell markers, CD44 (+) and CD24 (-). These results were correlated with hormonal and genetic risk factors for breast cancer. Triple immunofluorescenc

Validation of novel biomarkers for prostate cancer progression by the combination of bioinformatics, clinical and functional studies

The identification and validation of biomarkers for clinical applications remains an important issue for improving diagnostics and therapy in many diseases, including prostate cancer. Gene expression profiles are routinely applied to identify diagnostic and predictive biomarkers or novel targets for cancer. However, only few predictive markers identified in silico have also been validated for clin

An integrated acousto- and dielectrophoresis device for tumor cell separation, concentration, and single-cell trapping

Many microfluidic devices have been developed to separate rare cells, e.g. circulating tumor cells. The collection and analysis of the separated rare cells pose a challenge as it may lead to loss of target cells since extremely small number of cells are usually suspended in a large volume after separation. Here, we present an integrated device that allows acoustophoretic target cell separation and

Low physical activity is related to clustering of risk factors for fracture—a 2-year prospective study in children

Summary: The study investigates the effect of physical activity (PA) on a composite score for fracture risk in pre-pubertal children. Low PA in children is related to the composite score for fracture risk and the pre-pubertal years seem to be a period when PA positively affects the score. Introduction: This study evaluates if PA in children is related to clustering of risk factors for fracture. Re

Shared heritability and functional enrichment across six solid cancers

Quantifying the genetic correlation between cancers can provide important insights into the mechanisms driving cancer etiology. Using genome-wide association study summary statistics across six cancer types based on a total of 296,215 cases and 301,319 controls of European ancestry, here we estimate the pair-wise genetic correlations between breast, colorectal, head/neck, lung, ovary and prostate

Harnessing androgen receptor pathway activation for targeted alpha particle radioimmunotherapy of breast cancer

Purpose: The impact of androgen receptor (AR) activity Results: D-Norgestrel and DHT activated the AR pathway, in breast cancer biology is unclear. We characterized and while 17b-Estradiol did not. Competitive binding for AR tested a novel therapy to an AR-governed target in breast protein showed similar affinity between DHT and D-Norges-cancer. trel, indicating direct AR–ligand interaction. In vi

Agentic and visual effects of large-scale science research facilties

Large-scale science research facilities, such as those for investigation into the smallest components of physical matter, often consist of buildings with quite extraordinary features as regards shape and scale. These architectures are semiotically interesting in several ways: they have extraordinary outer forms that reflect the their inner activities; they require forms of mediation and planning t

Fast food outlets, physical activity facilities, and obesity among adults : a nationwide longitudinal study from Sweden

Background: While neighborhood deprivation is a well-known predictor of obesity, the mechanisms behind this association are unclear and these are important to clarify before designing interventions focusing on modifiable neighborhood environmental factors in order to reduce obesity risk. Objectives: This study examined the longitudinal association between availability of fast-food outlets and phys

Quantitative Time-Resolved Fluorescence Imaging of Androgen Receptor and Prostate-Specific Antigen in Prostate Tissue Sections

Androgen receptor (AR) and prostate-specific antigen (PSA) are expressed in the prostate and are involved in prostate cancer (PCa). The aim of this study was to develop reliable protocols for reproducible quantification of AR and PSA in benign and malignant prostate tissue using time-resolved fluorescence (TRF) imaging techniques. AR and PSA were detected with TRF in tissue microarrays from 91 PCa

An inflamed subtype of difficult-to-treat depression

BACKGROUND: Chronic low-grade inflammation may play a role in the pathophysiology of depression, at least in a subset of patients. High-sensitivity C-reactive protein (hs-CRP) has been used to define an inflamed subgroup of depression with specific clinical characteristics and symptoms. In this study we investigated biochemical and clinical characteristics in patients with difficult-to-treat depre

Identification of phenotypically, functionally, and anatomically distinct stromal niche populations in human bone marrow based on single-cell RNA sequencing

Hematopoiesis is regulated by the bone marrow (BM) stroma. However, cellular identities and functions of the different BM stromal elements in humans remain poorly defined. Based on single-cell RNA sequencing (scRNAseq), we systematically characterized the human non-hematopoietic BM stromal compartment and we investigated stromal cell regulation principles based on the RNA velocity analysis using s

Using Cluster Theory to Calculate the Experimental Structure Factors of Antibody Solutions

Monoclonal antibody solutions are set to become a major therapeutic tool in the years to come, capable of targeting various diseases by clever design of their antigen binding site. However, the formulation of stable solutions suitable for patient self-administration typically presents challenges, as a result of the increase in viscosity that often occurs at high concentrations. Here, we establish

Cv surinder 16

Microsoft Word - CV October 16.docx Surinder S. Jodhka Professor, Centre for the Study of Social Systems, School of Social Sciences Jawaharlal Nehru University, New Delhi 110 067. ssjodhka@yahoo.com; jodhka@mail.jnu.ac.in Phones: +91-11- 26704429 (work) 26741451 (home) +91-9868512761 (cell) Education: M.A. (1985); M.Phil. (1987); Ph.D. (1991) all in Sociology. Awards, Distinctions and Fellowships,

https://www.sasnet.lu.se/sites/sasnet.lu.se/files/cv_surinder_16.pdf - 2026-06-19

Studentguide 2019

Uppdaterad sommaren 2019 VÄLKOMMEN TILL LOGOPEDPROGRAMMET VID LUNDS UNIVERSITET Studentguide Lunds universitet grundades 1666 och i dag studerar ca 42 000 studenter på grundläggande och avancerad nivå. Universitetet har ca 3300 forskarstuderande och 7600 anställda. Det är med andra ord ett stort universitet som hälsar dig välkommen! Universitetet är indelat i ett antal områden, så kallade fakultet

https://www.student.med.lu.se/sites/student.med.lu.se/files/studentguide_2019.pdf - 2026-06-19

Studentguide logopedi 2017

Uppdaterad sommaren 2017 VÄLKOMMEN TILL LOGOPEDPROGRAMMET VID LUNDS UNIVERSITET Studentguide Lunds universitet grundades 1666 och i dag studerar ca 42 000 studenter på grundläggande och avancerad nivå. Universitetet har ca 3300 forskarstuderande och 7600 anställda. Det är med andra ord ett stort universitet som hälsar dig välkommen! Universitetet är indelat i ett antal områden, så kallade fakultet

https://www.student.med.lu.se/sites/student.med.lu.se/files/studentguide_logopedi_2017.pdf - 2026-06-19