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Frequency determination of rare populations by flow cytometry: A hematopoietic stem cell perspective.

Flow cytometry allows for identification of cellular subsets based on cell intrinsic properties, most often by the use of fluorochrome-conjugated antibodies recognizing distinct cell-surface epitopes that define the cells of interest. Advances in technical instrumentation and the availability of an ever-increasing number of fluorophores, today enables identification of multicolor defined cellular

Nanoconfined Circular and Linear DNA: Equilibrium Conformations and Unfolding Kinetics

Studies of circular DNA confined to nanofluidic channels are relevant both from a fundamental polymer-physics perspective and due to the importance of circular DNA molecules in vivo. We here observe the unfolding of confined DNA from the circular to linear configuration as a light-induced double-strand break occurs, characterize the dynamics, and compare the equilibrium conformational statistics o

Transforming growth factor (TGF)-β levels and unprovoked recurrent venous thromboembolism.

Prediction of recurrence in patients with unprovoked venous thromboembolism (VTE) remains a challenge. Studies of atherosclerosis suggest a protective role of transforming growth factor (TGF)-β. However, the role of TGF-β has not been studied in VTE. The aim of this study was to investigate TGF-β as a predictive marker of recurrent VTE in patients with a first episode of unprovoked VTE. Patients i

Associations of sex, anthropometric and reproductive factors with clinicopathological and molecular characteristics of colorectal cancer

Colorectal cancer (CRC) is the third most common cancer globally, with approximately 1.2 million new cases every year. The highest incidence rates are seen in developed countries, thereby imposing dietary and lifestyle factors in the etiology of CRC. Accumulating epidemiological evidence suggests that obesity is a risk factor for CRC in particular in men, as weak or no associations are seen in wom

Datakommunikation och nätverk

Datakommunikation och nätverk ger en heltäckande och lättillgänglig redogörelse av modern datakommunikation. Boken är ett alternativ till internationella textböcker i ämnet, innehållet speglar kunskapsbehovet hos yrkesverksamma ingenjörer och ger de kunskaper som krävs på ett pedagogiskt och kärnfullt sätt. Boken innehåller förutom övningar även lästips och hänvisningar för den som vill söka fördj

From Crew Resource Management to Operational Resilience

This paper questions the correspondance between resilience engineering theory and the theoretical fundaments of traditional CRM training, with its related behavior assessments. Reviewing the theoretical roots of CRM it is concluded that such concepts are rather founded in the information processing paradigm hiding the complexities of adaption to rapidly changing situations. An alternative approach

Societal consequences of critical infrastructure vulnerabilities: integrating power system and regional inoperability input-output models

Critical infrastructures provide indispensable services to society and extensive disruption of these give rise to large societal consequences. Most risk-related studies of critical infrastructures, however, focus rather narrowly on the direct consequences, e.g. expressed by services not supplied or cost of nonsupplied services. Although these measures might serve as a proxy for the direct societal

Comparison of vulnerability and reliability analysis of technical infrastructures

The society depends on reliable and robust services provided by technical infrastructures for its function. The impact of large-scale outages due to the inherent vulnerabilities of technical infrastructures has been demonstrated, for example, by the power outage in the U.S. in 2003 and the power outages in Sweden due to the storms Gudrun in January 2005 and Per in January 2007. Two of the main app

Rule- and Role-Retreat: An Empirical Study of Procedures and Resilience

To manage complex and dynamic socio-technical systems places demands on teams to deal with a range of more and less foreseeable situations. Three groups of participants with different maritime experiences were studied using the same simulation of a ship to better understand the role of generic competencies (e.g. information management, communication and coordination, decision making, and effect co

Analysing the vulnerability of electric distribution systems: A step towards incorporating the societal consequences of disruptions

Reliable electrical power supply is a prerequisite for the modern society, and if it fails it can cause severe consequences in terms of economic losses and even fatalities. It is thus important to analyse the vulnerability of the electric power system. Network analysis has previously been used to analyse the vulnerability of electric transmission systems, however recent events in Sweden have shown