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Technological readiness and implementation of genomic-driven precision medicine for complex diseases

The fields of human genetics and genomics have generated considerable knowledge about the mechanistic basis of many diseases. Genomic approaches to diagnosis, prognostication, prevention and treatment – genomic-driven precision medicine (GDPM) – may help optimize medical practice. Here, we provide a comprehensive review of GDPM of complex diseases across major medical specialties. We focus on tech

The metabolic signature of salt intake : a cross-sectional analysis from the SCAPIS-study

Background: Untargeted metabolomic analysis provides novel insights into the relationship between sodium intake and cardiometabolic risk. This study examined cross-sectional associations between estimated sodium intake and plasma metabolite profiles in a large Swedish cohort. Methods: This cross-sectional analysis was conducted in the in the SCAPIS cohort (mean age 50–64 years, n = 8,957). Sodium

The association between the gut microbiome and 24-h blood pressure measurements in the SCAPIS study

Background: There is mounting evidence supporting the role of the microbiota in hypertension from experimental studies and population-based studies. We aimed to investigate the relationship between specific characteristics of the gut microbiome and 24-h ambulatory blood pressure measurements. Methods: The association of gut microbial species and microbial functions, determined by shotgun metagenom

Legitimacy

Legitimacy is a relational concept that refers to the perception that the actions undertaken by an actor or an institution are rightful and acceptable. In political terms, an actor enjoys legitimacy if the way it exercises its power is widely considered warranted. In the framework of a major global political process such as the implementation of the 2030 Agenda for Sustainable Development, legitim

Responsibility

Responsibility refers to the obligations that an actor must fulfil. It can be allocated on the basis of different principles. Governments hold the main formal responsibility for the implementation of the Sustainable Development Goals (SDGs). Many other actors can also hold responsibility for accelerating SDG implementation. This is based on principles of closeness, capacity or having caused an out

Neurite density imaging versus imaging of microscopic anisotropy in diffusion MRI : A model comparison using spherical tensor encoding

In diffusion MRI (dMRI), microscopic diffusion anisotropy can be obscured by orientation dispersion. Separation of these properties is of high importance, since it could allow dMRI to non-invasively probe elongated structures such as neurites (axons and dendrites). However, conventional dMRI, based on single diffusion encoding (SDE), entangles microscopic anisotropy and orientation dispersion with

Spontaneous Recovery of Upper Extremity Motor Impairment After Ischemic Stroke : Implications for Stem Cell-Based Therapeutic Approaches

Preclinical studies suggest that stem cell therapy (SCT) may improve sensorimotor recovery after stroke. Upper extremity motor impairment (UEMI) is common after stroke, often entailing substantial disability. To evaluate the feasibility of post-stroke UEMI as a target for SCT, we examined a selected sample of stroke patients potentially suitable for SCT, aiming to assess the frequency and recovery

Stroke Prevalence, Mortality and Disability-Adjusted Life Years in Adults Aged 20-64 Years in 1990-2013: Data from the Global Burden of Disease 2013 Study

Background: Recent evidence suggests that stroke is increasing as a cause of morbidity and mortality in younger adults, where it carries particular significance for working individuals. Accurate and up-to-date estimates of stroke burden are important for planning stroke prevention and management in younger adults. Objectives: This study aims to estimate prevalence, mortality and disability-adjuste

Reduction of arterial partial volume effects for improved absolute quantification of DSC-MRI perfusion estimates: Comparison between tail scaling and prebolus administration.

To evaluate and mutually compare the tail-scaling approach and the prebolus administration concept for reduction of arterial partial volume effects (PVEs), because reproducible absolute quantification of cerebral blood flow (CBF) by dynamic susceptibility contrast magnetic resonance imaging (MRI) is often hampered by PVEs in the arterial input function (AIF) registration.

Label-free concentration of viable neurons, hESCs and cancer cells by means of acoustophoresis.

Concentration of viable cell populations in suspension is of interest for several clinical and pre-clinical applications. Here, we report that microfluidic acoustophoresis is an effective method to efficiently concentrate live and viable cells with high target purity without any need for protein fluorescent labeling using antibodies or over-expression. We explored the effect of the acoustic field

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Abstract in Danish Formål: Formålet er at beskrive tuberkulosens (tbc.) epidemiologi i Danmark de sidste 25 år, specielt udviklingen i den danske befolkning. Metode: Et registerstudie af anmeldte tilfælde af tbc. i Danmark 1972-1996: Fra 1970-1989 i DIKE's register, fra 1990-1996 i EPI-registeret, epidemiologisk afd., Statens Serum Institut. Resultater: tbc.-incidensen faldt jævnt fra 1972 indtiThe present study is based on notified cases of tuberculosis (TB) in the National tbc. register 1972-1996. A decline in Tb incidence was seen from 1972 and until the mid-1980's. Subsequently the trend has reversed due to an increasing number of TB cases in foreigners. In 1996, 60% of all cases of TB in Denmark were found in foreigners reflecting the rising number of refugees and their families arr

Protokoll kfs 240619-signed (1)

Sida 1 av 3 Fakultetsstyrelsen PROTOKOLL Diarienummer STYR 2024/1711 Sammanträdesdatum 2024-06-19 Konstnärliga fakultetsstyrelsens sammanträde 2024-06-19 Ledamöter Närvarande Staffan Storm, prodekan, mötesordförande Santino Resić, dekan – via Zoom Håkan Andersson, universitetslektor Musikhögskolan Sven Bjerstedt, docent Teaterhögskolan, justerare Mats Edén, universitetslektor Musikhögskolan Maria

https://www.konstnarliga.lu.se/sites/konstnarliga.lu.se/files/2024-06/protokoll_kfs_240619-signed%20(1).pdf - 2026-06-22

Geoa73-kursvardering

Manuskriptideer Kursvärdering 2013: GEOA73; Dinosauriernas värld (lärare: Johan Lindgren, Mats Eriksson, Per Ahlberg, Johan Gren, Sven Stridsberg, Vivi Vajda) SAMMANSTÄLLNING BASERAD PÅ 32 SVAR 1. Hur upplevde Du kursen i allmänhet (från 1-5 där 1 är usel och 5 är toppen)? Markera med kryss. (1) (2) (3) 3% (4) 47% (5) 50% 2. Hur upplevde Du föreläsningarna (från 1-5 där 1 är usel och 5 är toppen)?

https://www.geologi.lu.se/sites/geologi.lu.se/files/geoa73-kursvardering.pdf - 2026-06-22

Symtom och behandlingar

PowerPoint-presentation 2019-05-29 1 Hjärnligen Neurologiska Kliniken-Lund Skånes universitetssjukhus Huntingstons sjukdom Symtom och nuvarande behandlingar Håkan Widner Professor, överläkare Neurologiska kliniken Skånes universitetssjukhus hakan.widner@skane.se Hjärnligen Neurologiska Kliniken-Lund Skånes universitetssjukhus Behandlingar Kunskap Strategier Läkemedel Behandlingar – träning – kost-

https://www.huntington-research.lu.se/sites/huntington-research.lu.se/files/symtom_och_behandlingar.pdf - 2026-06-22

Oettle ruth

Microsoft Word - Thesis of Ruth Oettle The Environment for sale? The examination of the critical features of a third‐party in facilitating a transaction in the market for environmental offsets. Ruth Oettle ruth.oettle@gmail.com 25 May 2008 Submitted in partial fulfilment of the requirements for the International Master’s Programme in Environmental Studies and Sustainability Science (LUMES), Lund U

https://www.lumes.lu.se/sites/lumes.lu.se/files/oettle_ruth.pdf - 2026-06-22