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Previous open-label trials testing glial cell line-derived neurotrophic factor (GDNF) family ligands in Parkinson disease have shown promising clinical effects. However, in placebo-controlled trials, the treatments have failed. A new randomized placebo-controlled trial of intraputamenal delivery of GDNF designed to resolve this conundrum has again failed to do just that.

Feedback control is increasingly being applied in server systems to make them more robust and efficient. This includes managing quality of service, minimizing power consumption, and adapting to varying workloads. Successful adaptation and control in turn relies on accurate tracking of workload variations and timely detection of changes in the computing infrastructure. Given that server systems are

The literature on employee spinoffs has, for a long time, stressed the importance of industry-specific skills and experiences in explaining the success of new firms. We argue that employees also develop skills that are associated with their occupation within an industry, and that success as an entrepreneur, therefore, is also contingent on the relation between the entrepreneurs’ previous occupatio

Abstract is not available

Mononuclear iron(iv)-oxo, iron(iv)-imido and iron(iv)-nitrido complexes are common catalytic cycle intermediates in enzymes, where the metal is typically linked to the protein through cysteinate or histidine sidechains. Enzymatic high-valent iron(iv)-imido and -nitrido intermediates have never been trapped and characterized; hence, there is uncertainty regarding their structure and function. Using

Social media, search engines, and recommendation systems provide a constant stream of data that shapes our knowledge, beliefs and decisions. We are constantly presented with content from a variety of sources, often without context. This content gets amalgamated into new constellations in the feeds, lists and streams we encounter (and sometime curate) on our devices. With the rise of consumer-facin

Large landed estates often have an interesting history, worth digging into. Labour hiring is usually regarded as the capitalist relation of production. A classic study from the 1980s of salad farms in California, United States of America (USA), showed that farm workers were recruited from highly segmented niches in the labour market, with illegal immigrants at the lower rungs doing the most tediou

This paper argues that conventional blame practices fall short of capturing the complexity of moral experiences, neglecting power dynamics and discriminatory social practices. It is evident that robots, embodying roles linked to specific social groups, pose a risk of reinforcing stereotypes of how these groups behave or should behave, so they set a normative and descriptive standard. In addition,

This paper provides a historical overview of the United Nations Framework Convention on Climate Change Conference of the Parties meetings and reviews the major outcomes of the meetings up to the most recent, which took place in Dubai. We describe how climate negotiations, agreements and policies have evolved, summarise the main points reached, and highlight the key concerns of low-income countries

In this short podcast, we define ageism and describe how it is quietly pervasive in our everyday lives. We discuss the negative impacts of ageism, provide examples, and identify ways to combat ageism. Target audience: high school/secondary school students. Music and mixing by Sean Mac.En este breve podcast, hablamos sobre el edadismo o discriminación por edad y describimos cómo está silenciosament

The purpose with this thesis is to examine if strategic and tactical asset allocation are used within Swedish balanced funds and to outline how these investment strategies are used, by identifying trends. Compiled data over the asset allocation within Swedish balanced funds 12 years back has been analyzed by defining strategic and tactical asset allocation in quantitative terms. With several hypo

Over the last decade the anti-corruption movement, led by the Berlin-based NGO Transparency International (TI), as grown to include 90 affiliates throughout the world. While pursuing laudable goals to raise awareness about corruption, promulgate and enforce anti-corruption conventions, pursue anti-corruption projects and embarrass corrupt governments thorugh its Corruption Perception Index and Bri

This letter addresses the robustness of a prescribed-time observer for a class of nonlinear systems in the presence of disturbances and unmodeled dynamics. It is proven and demonstrated through simulations that the proposed observer completely rejects the effects of large bounded disturbances and unmodeled dynamics, enabling accurate estimation of both the states and the disturbances. Furthermore,

Objectives: This Study examines the initial course of the fibronlyalgia syndrome [FMS] and the influence of physical and psychosocial work-place factors on developing FMS. Methods: Patients with FMS were recruited to participate in a structured interview about pain and physical and psychosocial load. In addition, they participated in a clinical examination. Physical load in occupational life was a