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Regulation of Human Papillomavirus Type 16 Late L1 mRNA Splicing

Human papillomaviruses (HPVs) cause almost half of the human cancers that are attributable to viruses. HPV type 16 is the most carcinogenic type among the HPVs and is detected in 50% of all cervical cancers. HPV-16 infects epithelial cells and HPV-16 gene expression is tightly linked to the differentiation stage of the infected cells. Early HPV-16 genes are expressed in basal layers of the epithel

Characterization of Membrane Proteins: From a gated plant aquaporin to animal ion channel receptors

Membrane proteins play several important roles in a cell. Among these proteins are aquaporins (AQPs) and transient receptor potential (TRP) ion channels that mediate water transport, temperature and noxious chemical sensation, respectively. The function of some AQPs, for example the spinach isoform SoPIP2;1 is regulated by pH, phosphorylation and heavy metals such as mercury. However, the mechanis

Att skapa ordning : Den systematiska samlaren

For a collection to be considered as such, and not appear only as a clutter or jumble of things, it has to be based on some kind of selection and systematisation. The research question of this article is how and why collectors structure their collections, organise, and arrange them. The research material is answers to the directive “Collecting things”, presented by the Mass Observation Archive in

Perceived research needs for Battery and Hydrogen Safety : A Nordic Perspective

Changes in the energy landscape relating both to the ambitions of a green energy transformation as well as increasing global security concerns, have led to increased attention to new energy carriers. These can serve the role of allowing for the electrification of transport and decarbonization of industries as well as to reduce the effects of variation in many sustainable energy sources such as win

From ancient herbs to modern drugs : In search of alternatives for cancer therapy

Breast cancer is the major cause of deaths related to cancer for women worldwide. Although much is known about this malignancy, extensive research is still needed to gain complete understanding of the complexity of the disease. The inter and intra tumor heterogeneity is an important trait of breast cancer. The intratumor heterogeneity is reflected in sub-populations of cancer cells that appear to

Emergency preparedness for Small Modular Reactors (SMRs) : the case of Sweden

Small modular reactors (SMRs) have become part of the solution for futurefossil-free energy systems. Compared to traditional nuclear power plants (NPPs), risks are different and additional actors are involved. The aim of this paper is to analyse key actors’ understanding of emergency preparedness for SMRs in Sweden. Emergency preparedness is an active, continuous and integrated process involving a