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Canesin et al. describe a role and mechanism for labile heme as a key player in regulating gene expression to promote carcinogenesis via binding to G-quadruplex in the c-MYC promoter. Hemopexin, a heme scavenger, may be used as a strategy to block progression of cancer.
We recently demonstrated that the LKB1 tumour suppressor kinase, in complex with the pseudokinase STRAD and the scaffolding protein MO25, phosphorylates and activates AMP-activated protein kinase (AMPK). A total of 12 human kinases (NUAK1, NUAK2, BRSK1, BRSK2, QIK, QSK, SIK, MARK1, MARK2, MARK3, MARK4 and MELK) are related to AMPK. Here we demonstrate that LKB1 can phosphorylate the T-loop of all
Background: This study assessed the cost-effectiveness of indacaterol/glycopyrronium (IND/GLY) versus salmeterol/fluticasone (SFC) in chronic obstructive pulmonary disease (COPD) patients with moderate to very severe airflow limitation and ≥1 exacerbation in the preceding year. Methods: A previously published and validated patient-level simulation model was adapted using clinical data from the FLA
Freezing is a method used to preserve food for long periods of time by reducing the rate of naturally occurring reactions and growth of microorganisms. However, some irreversible quality changes, both physical and chemical, can take place during the freezing step. After being frozen, the products are stored until thawed and consumed. This thesis studies innovative freezing technologies to understa
Carbon offsetting is one strategy to tackle global climate change and decrease the level of greenhouse gases in the atmosphere. However, the strategy is debated and concerns are raised regarding negative impacts on the surrounding environment and biodiversity, the effectiveness and the morality of “buying the right to pollute”. The aim of this paper is to examine if ecological aspects are consider
Vangueria infausta (African medlar) is a wild fruit found in southern and central Mozambique. The ripe fruit has a leathery skin enclosing three to five seeds embedded in a soft pulp that tastes like apple. It plays an important role in the diet of the rural population and has the potential for commercial use. The fruit is mostly eaten fresh, and sometimes mixed with porridges, but in some parts
The purpose of the thesis is to investigate how the semiconductor industry will develop during the period 2007-2012. Issues: The main issues presented are: • How will the competitive landscape change from 2007 to 2012? • How will companies succeed in the industry in 2012? • What position will the Integrated Device Manufacturers take in the value chain in 2012? Method: In order to achieve the purpo
Sweden was once known for its open and generous refugee reception, with a mindset that was different from its neighbouring countries. However, this has changed in recent years. Due to an increased influx of people seeking asylum in Sweden, restrictive measures were put in place. The political discourse on migration shifted from a welcoming narrative to enforcing border controls and limiting access
Modern slavery is connected to the global trade and company supply chains. This essay aims to examine how this is regulated and addressed today, from a legal and corporate social responsibility (CSR) perspective, and analyse the extent to which such obstacles can be overcome. To reach the aim of this study, a traditional legal dogmatic method, together with an empirical method in the form of a cas
Purpose: This study intends to explore how video games companies work with strategic brand management. Methodology: A qualitative literature review and case study of Blizzard Entertainment using Kapferer’s Brand Identity Prism. The data was collected from Blizzard as well as other secondary sources. Findings: The findings of this paper shows that Kapferer’s Brand Identity Prism was applicable to t
Existing research acknowledges users as an important external source of innovation for firms, but mainly focuses on user innovation in mature firms. The aim of this paper is to understand why and how startups strategically integrate users in the innovation process. To achieve this purpose we chose an abductive, qualitative research approach and conducted a multiple case study on six Swedish high-t
With an increasing focus on the national tests in Sweden, investigating how the tests affect teachers is highly relevant. The aim of this study is to provide further insight as to what role the national tests in English 5 and 6 play on teacher mindset, in order to allow for an informed evaluation of the role they play in assessment. This was achieved by a mixed methods approach, using both a quest
Discourse of reshoring as a possible risk mitigation strategy during times of uncertainty has during the recent decade become more prominent. This thesis examines the casual relationship between uncertainty and reshoring within the electrical manufacturing and pharmaceutical manufacturing industries in the U.S. The research question proposed is: How efficient are measures of uncertainty in predict
This bachelor thesis focuses on the democratic transition in Argentina in the begin¬ning of the 1980s and aims to expose several variables within this political develop¬ment by using a method of process tracing. What many scholars have failed to notice is the role that women's movements in Latin America have had in this process. The authoritarian regime in Argentina also failed to acknowledge
The purpose of this study is to investigate how peace and conflict within Nigeria can be understood. This is done by the application of a range of developmental indicators as well as theoretical variables drawn from the field of why insurgencies emerge. This study also includes the role of the Nigerian state in this dynamic. The applied method is a within-case comparison of three cases; the North
The concern raised in this paper is whether the cone of diversification for EU to its low income trading partners has become more similar over time, as this would imply a risk for a Stolper- Samuelson effect. In order to assess this risk, the methodology in this paper is designed to capture any rising similarities of EU to its trading partners since a Stolper- Samuleson effect infers that the good
