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Carbon offsetting is one strategy to tackle global climate change and decrease the level of greenhouse gases in the atmosphere. However, the strategy is debated and concerns are raised regarding negative impacts on the surrounding environment and biodiversity, the effectiveness and the morality of “buying the right to pollute”. The aim of this paper is to examine if ecological aspects are consider
Objective. We recently showed that plasma concentration of N-terminal atrial natriuretic peptide (Nt-proANP) is strongly directly related to salt sensitivity. The aims of the present study were to test (i) whether plasma concentration of N-terminal brain natriuretic peptide (Nt-proBNP) is related to salt sensitivity and (ii) whether Nt-proANP, as a marker of salt sensitivity, differs between type
Systemic lupus erythematosus (SLE, OMIM 152700) is a complex autoimmune disease that affects 0.05% of the Western population, predominantly women(1-4). A number of susceptibility loci for SLE have been suggested in different populations, but the nature of the susceptibility genes and mutations is yet to be identified(5-9). We previously reported a susceptibility locus (SLEB2) for Nordic multi-case
We recently demonstrated that the LKB1 tumour suppressor kinase, in complex with the pseudokinase STRAD and the scaffolding protein MO25, phosphorylates and activates AMP-activated protein kinase (AMPK). A total of 12 human kinases (NUAK1, NUAK2, BRSK1, BRSK2, QIK, QSK, SIK, MARK1, MARK2, MARK3, MARK4 and MELK) are related to AMPK. Here we demonstrate that LKB1 can phosphorylate the T-loop of all
The purpose of this study is to investigate how peace and conflict within Nigeria can be understood. This is done by the application of a range of developmental indicators as well as theoretical variables drawn from the field of why insurgencies emerge. This study also includes the role of the Nigerian state in this dynamic. The applied method is a within-case comparison of three cases; the North
A testicular form of hormone-sensitive lipase (HSLtes), a triacylglycerol lipase, and cholesterol esterase, is expressed in male germ cells. Northern blot analysis showed HSLtes mRNA expression in early spermatids. Immunolocalization of the protein in human and rodent seminiferous tubules indicated that the highest level of expression occurred in elongated spermatids. We have previously shown that
Development aid organizations are increasingly turning their focus on men and masculinities in the pursuit of women’s empowerment. Despite much effort to improve the lives of women, the hegemonic definition of empowerment in economic and individualistic terms have not been able to attack the unequal power structures between men and women, causing them to persist until this day. This essay explores
Existing research acknowledges users as an important external source of innovation for firms, but mainly focuses on user innovation in mature firms. The aim of this paper is to understand why and how startups strategically integrate users in the innovation process. To achieve this purpose we chose an abductive, qualitative research approach and conducted a multiple case study on six Swedish high-t
With an increasing focus on the national tests in Sweden, investigating how the tests affect teachers is highly relevant. The aim of this study is to provide further insight as to what role the national tests in English 5 and 6 play on teacher mindset, in order to allow for an informed evaluation of the role they play in assessment. This was achieved by a mixed methods approach, using both a quest
Discourse of reshoring as a possible risk mitigation strategy during times of uncertainty has during the recent decade become more prominent. This thesis examines the casual relationship between uncertainty and reshoring within the electrical manufacturing and pharmaceutical manufacturing industries in the U.S. The research question proposed is: How efficient are measures of uncertainty in predict
Sweden was once known for its open and generous refugee reception, with a mindset that was different from its neighbouring countries. However, this has changed in recent years. Due to an increased influx of people seeking asylum in Sweden, restrictive measures were put in place. The political discourse on migration shifted from a welcoming narrative to enforcing border controls and limiting access
Modern slavery is connected to the global trade and company supply chains. This essay aims to examine how this is regulated and addressed today, from a legal and corporate social responsibility (CSR) perspective, and analyse the extent to which such obstacles can be overcome. To reach the aim of this study, a traditional legal dogmatic method, together with an empirical method in the form of a cas
The R620W variant of PTPN22 is one of the major genetic risk factors for several autoimmune disorders including type 1 diabetes (T1D) in humans. In the BioBreeding T1D-prone (BBDP) rat, a single nucleotide polymorphism in Ptpn22 results in an A629T substitution immediately C-terminal to the aliphatic residues central to the Ptpn22-C-terminal Src kinase interaction. This variant exhibits a 50% decr
Introduction: Progression of joint destruction in rheumatoid arthritis (RA) is partly heritably; 45 to 58% of the variance in joint destruction is estimated to be explained by genetic factors. The binding of RANKL (Receptor Activator for Nuclear Factor kappa B Ligand) to RANK results in the activation of TRAF6 (tumor necrosis factor (TNF) receptor associated factor-6), and osteoclast formation ult
The human seminal vesicles secrete two proteins, semenogelin I and semenogelin II, at very high concentrations. It has previously been shown that the cotton-top tamarin (Sanguinus oedipus), a New World monkey, is lacking the semenogelin II gene. We have now determined the nucleotide sequence of DNA located 5--13 kilobases (kb) downstream of the tamarin semenogelin I gene---a region that in man is
