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Glucose transporters (GLUTs) are responsible for transporting hexose molecules across cellular membranes. In adipocytes, insulin stimulates glucose uptake by redistributing GLUT4 to the plasma membrane. In unstimulated adipose-like mouse cell lines, GLUT4 is known to be retained intracellularly by binding to TUG protein, while upon insulin stimulation, GLUT4 dissociates from TUG. Here, we report t
Background: 4-1BB (CD137) is a co-stimulatory receptor highly expressed on tumor reactive effector T cells and NK cells, which upon stimulation prolongs persistence of tumor reactive effector T and NK cells within the tumor and induces long-lived memory T cells. 4-1BB agonistic antibodies have been shown to induce strong anti-tumor effects that synergize with immune checkpoint inhibitors. The firs
This paper estimates labor supply effects for informal caregivers in Sweden using four waves of the SHARE data panel. To give daily or weekly care to a parent, step parent or parent in law is found to be more common among women than among men and is associated with lower employment probability for daily caregivers although the causal direction of the relationship is unclear. No negative effect of
Purpose: The accuracy of analytical dose calculations (ADC) and dose uncertainties resulting from anatomical changes are both limiting factors in proton therapy. For the latter, rapid plan adaption is necessary; for the former, Monte Carlo (MC) approaches are increasingly recommended. These, however, are inherently slower than analytical approaches, potentially limiting the ability to rapidly adap
Hu11B6 is a monoclonal antibody that internalizes in cells expressing androgen receptor (AR)-regulated prostate-specific enzyme human kallikrein-related peptidase 2 (hK2; KLK2). In multiple rodent models, Actinium-225-labeled hu11B6-IgG1 ([225Ac]hu11B6-IgG1) has shown promising treatment efficacy. In the present study, we investigated options to enhance and optimize [225Ac]hu11B6 treatment. First,
Today, we live in an age that is continually witnessing tension, strife and terrorism as a direct product of unequal distribution of wealth and opportunities for a good life. In Uganda for over two and half decades, war, insurgency and deprivation have been the realities of the people living in Northern Uganda. This evidently has lead to an imbalance in the Ugandan society with the North standing
Background: There are known associations between cardiovascular disease (CVD)-related plasma proteins and spirometry measures. Diffusing capacity for carbon monoxide (DLCO) measures gas exchange that can be impaired both by lung and heart diseases. We aimed to study the associations between DLCO and CVD-linked plasma proteins in a population-based cohort without airflow obstruction. Methods: 89 CV
OBJECTIVE: Emergency department length of stay (EDLOS) is linked to crowding and patient outcomes whereas worse prognosis in low socioeconomic status remains poorly understood. We studied whether income was associated with ED process times among patients with chest pain.METHODS: This was a registry-based cohort study on 124,980 patients arriving at 14 Swedish EDs between 2015 and 2019 with chest p
A Palaeolithic diet is an efficacious dietary approach for glycaemic control in type 2 diabetes. Causal mechanisms are body weight loss and glucometabolic effects from differences in included food groups, macronutrient composition, fibre content, and glycaemic load. The aim was to test the hypothesis that characteristic food group differences between a Palaeolithic and a diabetes diet would cause
The Gram-positive bacterium Streptococcus pneumoniae is a major human pathogen that causes infections ranging from acute otitis media to life-threatening invasive disease. Pneumococci have evolved several strategies to circumvent the host immune response, in particular the complement attack. The pneumococcal glycolytic enzyme phosphoglycerate kinase (PGK) is both secreted and bound to the bacteria
Objectives: Cadmium (Cd) toxicity of the kidney varies between individuals despite similar exposure levels. In humans Cd is mainly bound to metallothioneins (MT), which scavenge its toxic effects. Here we analyzed whether polymorphisms in MT genes MTIA and MT2A influence Cd-related kidney damage. Methods: In a cross-sectional study N = 512 volunteers were selected from three areas in South-Eastern
Objectives To investigate the possible impact of maternal obesity on ultrasonographic dating of pregnancy. Methods The Swedish Medical Birth Registry was used to identify 842 083 singleton pregnancies for which the estimated date of deliver), (EDD) according to last menstrual period (EDD-LMP) and according to ultrasound examination (EDD-US) and maternal body mass index (BMI) in early pregnancy wer
9 december 2025 16:00 till 17:00 | Workshop Creating a research network to foster woman's participation in technoscience. An online lecture in the serie Girls Just Want To Have Sc(AI)ence.Topic: Cognizing Subjects: Our Human Futures with Our Nonhuman SymbiontsInvited speaker: N. Katherine Hayles, N. Katherine Hayles Distinguished Research Professor at the University of California, Los Angeles, and
https://www.lu.se/evenemang/girls-scaience-6-cognizing-subjects-our-human-futures-our-nonhuman-symbionts - 2026-07-18
The purpose of the thesis is to investigate how the semiconductor industry will develop during the period 2007-2012. Issues: The main issues presented are: • How will the competitive landscape change from 2007 to 2012? • How will companies succeed in the industry in 2012? • What position will the Integrated Device Manufacturers take in the value chain in 2012? Method: In order to achieve the purpo
