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Objective To investigate whether polymorphisms in Toll-like receptor (TLR) genes, previously reported to be associated with immune-mediated diseases, are involved in systemic sclerosis (SSc). Methods. We genotyped 14 polymorphisms in the genes for TLRs 2, 4, 7, 8, and 9 in a discovery cohort comprising 452 SSc patients and 537 controls and a replication cohort consisting of 1,170 SSc patients and
Purpose Although there is evidence for interaction between epidermal growth factor receptor ( EGFR) and estrogen receptor ( ER), it is still not clear how this affects response to endocrine therapies like tamoxifen. Here we assess the relationship between EGFR expression and tamoxifen response, with a new quantitative technology. Patients and Methods A tissue microarray was constructed from breast
The molecular mechanism of substrate analogue interaction with Escherichia coli dUTPase was investigated, using the non-hydrolyzable 2'-deoxyuridine 5'-(α,β-imido)triphosphate (α,β-imido-dUTP). Binding of this analogue induces a difference in the far UV circular dichroism (CD) spectrum arguing for a significant change in protein conformation. The spectral shift is strictly Mg2+-dependent, does not
This thesis aims to reveal the role and significance of occupational clothing for the wearers, exposing some of the thoughts, ideas and opinions that pharmacy workers have about their work uniform, the white coat. My own experiences from working in an environment (a pharmacy) where occupational uniforms were used was one of the reasons for selecting this thesis topic. My interest was also consolid
Background: Diagnosis of Mycoplasma pneumoniae (MP) infection is traditionally based on serology, which may require more than two weeks for diagnostic antibodies to develop. PCR-based methods offer earlier diagnosis. During a community outbreak of MP infection, we compared seminested and real-time PCR of oropharyngeal swabs with serology for diagnosis of MP infection at different time points after
This master thesis explores the possibilities of social robot adoption in the hotel industry. Social robots represent a new product group, a radical innovation, that has yet not seen commercialization in the hotel industry in Sweden. Furthermore, previous research has requested studies that determine success factors for social robot adoption in specific markets. This thesis therefore investigates
In Swedish schools, a warm lunch is served every day. The lunch is prepared in a largescale food service system and includes steam-cooked potatoes several times per week. The potatoes are often industrially pre-treated to facilitate the handling and logistics required to cook hundreds of meals in a couple of hours. During the industrial pretreatment, the potato tubers are usually peeled by abrasio
BACKGROUND: Participants' study satisfaction is important for both compliance with study protocols and retention, but research on parent study satisfaction is rare. This study sought to identify factors associated with parent study satisfaction in The Environmental Determinants of Diabetes in the Young (TEDDY) study, a longitudinal, multinational (US, Finland, Germany, Sweden) study of children at
After the well-known spike in migrants crossing the Mediterranean in 2015- 2016, the EU has intensified its cooperation with third states on the field of migration. Although there are numerous examples where such policies have been criticised as incompatible with the principle of non-refoulement and for not respecting migrants’ human rights, there are no CJEU rulings concerning their complianc
Professor emeritus Kontaktinformation E-post: torleif [dot] bramryd [at] ses [dot] lu [dot] se Telefon: +46 42 35 65 65 Mobil: +46 70 393 98 55Organisation Institutionen för tjänstevetenskap WebbplatsTorleif Bramryds profil i Lunds universitets forskningsportalAndra roller Forskare Institutionen för tjänstevetenskap Publikationer Visar av publikationer. Sorterade efter år och sen titel. Filtrera e
https://www.ses.lu.se/torleif-bramryd - 2026-07-01
The biogeochemical cycling of silicon (Si) along the land-to-ocean continuum is studied by a variety of research fields and for a variety of scientific reasons. However, there is an increasing need to refine the methodology and the underlying assumptions used to determine biogenic silica (BSi) concentrations. Recent evidence suggests that contributions of nonbiogenic sources of Si dissolving durin
In his recent work, Eco abandons his conventionalist theory of pictures, which was heavily censored by, among others, the present author. In so doing, however, Eco now goes to the other extreme, claiming that television images are like mirrors, which are no signs. It is my contention that Eco fails to come up with a more acceptable theory of iconicity. Since Eco is one of the few semioticians conc
Historically, Q-wave myocardial infarction (MI) has been equated with transmural MI. This association have, however, recently been rejected. The endocardial extent of MI is another potential determinant of pathological Q waves, since the first part of the QRS complex where the Q wave appears reflects depolarization of subendocardial myocardium. Therefore, the aim of the present study was to test t
The thesis explores the obligation in international law to protect the ecological integrity of transboundary watercourses. The thesis specifically examines the obligation to protect environmental flows, which essentially means to protect a certain water flow for the benefit of freshwater ecosystems and the ecosystem services they supply. The obligation to protect the integrity of transboundary wat
