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hEP4-R (human prostaglandin E2 receptor, subtype EP4) is a Gs-linked heterotrimeric GPCR (G-protein-coupled receptor). It undergoes agonist-induced desensitization and internalization that depend on the presence of its C-terminal domain. Desensitization and internalization of GPCRs are often linked to agonist-induced b-arrestin complex formation, which is stabilized by phosphorylation. Subsequentl
Background: Suspected appendicitis is one of the most common indications for acute laparotomy or laparoscopy. The negative laparotomy and laparoscopy rates are high, often in the range of 15-30%, and especially high in some groups of patients such as women of child-bearing age and young patients. Different scoring systems have been introduced in order to improve diagnostic accuracy. The aim of the
Unlike the Quebec classification system, which is based primarily on pathoanatomy, a new Swedish classification system is based on the site of functional impairment and disability. A prospective study was performed on 85 patients with whiplash-associated disorders grade II according to the Quebec classification. The patients were examined 3-36 months following trauma. A team of professionals with
Objective: To describe the development and evaluation of the content and face validity and test-retest reliability of a disease-specific questionnaire that measures patient-reported outcomes and experiences for the Swedish National Diabetes Register for adult patients who have type 1 or type 2 diabetes. Methods: In this methodological study, a questionnaire was developed over four phases using an
Aim: To study (a) the covariation between patient reported experience measures (PREMs) and registered process measures of access and continuity when ranking providers in a primary care setting, and (b) whether registered process measures or PREMs provided more or less information about potential linkages between levels of access and continuity and explaining variables. Background: Access and conti
Introduction: To investigate the incidence of neonatal early-onset group B streptococcal (GBS) infection in Sweden after promulgation of guidelines (2008) for risk factor-based intrapartum antibiotic prophylaxis, and evaluate the presence of risk factors and obstetric management in mothers. Material and methods: National registers were searched for infants with early-onset GBS infection during 200
Objective To evaluate the effectiveness of oral glucosamine in subgroups of people with hip or knee osteoarthritis (OA) based on baseline pain severity, body mass index (BMI), sex, structural abnormalities and presence of inflammation using individual patient data. Methods After a systematic search of the literature and clinical trial registries, all randomised controlled trials (RCTs) evaluating
The thermal environment experienced by birds during early postembryonic development may be an important factor shaping growth and survival. However, few studies have directly manipulated nest temperature (T n) during the nestling phase, and none have measured the consequences of experimental heat stress on nestlings’ body temperature (T b). It is therefore not known to what extent any fitness consThe thermal environment experienced by birds during early postembryonic development may be an important factor shaping growth and survival. However, few studies have directly manipulated nest temperature (T n) during the nestling phase, and none have measured the consequences of experimental heat stress on nestlings’ body temperature (T b). It is therefore not known to what extent any fitness cons
ABSTRACT Aims: To compare two versions of a questionnaire translated using forward-backward (FB) translation and dual-panel (DP) methodologies regarding preference of wording and psychometric properties. Methods: The Rheumatoid Arthritis Quality of Life instrument was adapted into Swedish by two independent groups using FB and DP methodologies, respectively. Seven out of thirty resulting items wer
How do joint measures of premorbid cognitive ability and familial cognitive aptitude (FCA) reflect risk for a diversity of psychiatric and substance use disorders? To address this question, we examined, using Cox models, the predictive effects of school achievement (SA) measured at age 16 and FCA—assessed from SA in siblings and cousins, and educational attainment in parents—on risk for 12 major p
Background: Pregnant women with depression and/or anxiety prior to pregnancy are at higher risk of preterm birth, breastfeeding problems, postpartum depression, and disruption of the mother-infant attachment. It is well documented that exercise improves psychological well-being in nonpregnant subjects with symptoms of depression. However, in only a few small studies have researchers examined the e
Charged Higgs bosons produced in association with a single top quark and decaying via H±→τν are searched for with the ATLAS experiment at the LHC, using proton–proton collision data at s=13 TeV corresponding to an integrated luminosity of 3.2 fb−1. The final state is characterised by the presence of a hadronic τ decay and missing transverse momentum, as well as a hadronically decaying top quark, r
Introduction: Airway obstruction and possible concomitant pulmonary diseases in COPD cannot be identified conventionally with any single diagnostic tool. We aimed to diagnose and grade COPD severity and identify pulmonary comorbidities associated with COPD with ventilation/perfusion single-photon emission computed tomography (V/P SPECT) using Technegas as the functional ventilation imaging agent.
Prostate-specific antigen (PSA) testing has limited accuracy for the early detection of prostate cancer (PCa).
I slutet av 2014 hade 38 miljoner människor runt om i världen flytt sina hem till följd av krig, konflikt och våld. Att rädda liv och minska lidandet för dessa flyktingar är syftet med humanitärlogistik. Beredskap en nyckelroll i humanitära organisationer eftersom det är ett verktyg för att minska det negativa genomslaget av framtida händelser. En vanlig beredskapsåtgärd är att så kallad för-positAt the end of 2014, 38 million people around the world had fled their homes due to man-made disasters such as war, armed conflict and violence. To save the lives and alleviate the suffering of these refugees and displaced is the purpose of Humanitarian Logistics. Preparedness is of key importance in humanitarian organisations as it is a tool to reduce the impact of coming events. One common prepar
Lesbian, gay, and bisexual people continue to face discrimination and persecution in their daily lives, often from both the state and their communities. Where states do not provide for the basic human rights and physical security of their lesbian, gay, and bisexual citizens, many such citizens would flee their countries of origin in search of refuge in more hospitable countries. If other countries
Vi spenderar stor del av livet i urbana miljöer och majoriteten av landets befolkning påverkas dagligen av utformningen av stadens rum, vilket gör det intressant att undersöka hur stadskärnorna är utformade. Handeln i stadskärnorna förlorar idag mar knadsandelar till externa köpcentrum och e-handeln. För att förändra handelsplatser i stadskärnor till att bli mer attraktiva och konkurrenskraftiga kThis study aims to explain the structure and content of Swedish city centres. The distribution and density of commercial activities in the cities are analysed with network constrained methods (Kernel density estimation, Ripley’s K-function and centrality measures) in GIS-programs. External shopping centres and economic theories are used as a benchmark against which city centres are compared. The
