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Objective: Five double-blind, randomized, saline-controlled trials (RCTs) were included in the United States marketing application for an intra-articular hyaluronan (IA-HA) product for the treatment of osteoarthritis (OA) of the knee. We report an integrated analysis of the primary Case Report Form (CRF) data from these trials. Method. Trials were similar in design, patient population and outcome
Background Low competence levels among nursing staff have been associated with lower quality of elderly care. However, interventions aimed at improving nursing staff competence have not always been evaluated for their possible impact on the quality of elderly care. An educational intervention in the form of a workplace “toolbox” was shown to have positive effects on nursing staff competence and wo
A European web-based registry for refractive surgery was established in 2008; The European Registry of Quality Outcomes for Cataract and Refractive Surgery (EUREQUO). The aim of the registry was to improve treatment and standards of care for refractive surgery. Further aims were to offer a tool for benchmarking by establishing a reference database and for surgeons to enter and analyze their own ou
This Letter presents a search for a heavy neutral particle decaying into an opposite-sign different-flavor dilepton pair, e(+/-) mu(-/+), e(+/-) tau(-/+), or mu(+/-) tau(-/+) using 20.3 fb(-1) of pp collision data at root s = 8 TeV collected by the ATLAS detector at the LHC. The numbers of observed candidate events are compatible with the standard model expectations. Limits are set on the cross se
Water is arguably the world’s most valuable endangered resource, the management of which has been subject of contentious debate that in recent years has gained growing political, economic and media attention. This study intends to make use of that momentum by constructing a framework for quantifying global water crisis risk that is applied to assess both the EU’s share of such risk and the success
The complexity and importance of the eyes of a rather simple organism, the bee, is apparent when looking at the adaptation to their environment. The so called compound eyes consists of multiple facets, each having their own point of view and combined results in a larger image. For being able to study the magnificent eyes on a bee's head, there have been in recent studies an increase by X-ray t
BACKGROUND: Changes in glycosylation of serum proteins are common, and various glycoforms are being explored as biomarkers in cancer and inflammation. We recently showed that glycoforms detected by endogenous galectins not only provide potential biomarkers, but also have different functions when they encounter galectins in tissue cells. Now we have explored the use of a combination of two galectin
Two searches for supersymmetric particles in final states containing a same-flavour opposite-sign lepton pair, jets and large missing transverse momentum are presented. The proton-proton collision data used in these searches were collected at a centre-of-mass energy root s = 8TeV by the ATLAS detector at the Large Hadron Collider and corresponds to an integrated luminosity of 20.3 fb(-1). Two lept
A method for the quantitative determination of non-steroidal anti-inflammatory drugs (NSAIDs) in sewage sludge was developed and validated. The target compounds were extracted using pressurized hot water extraction (PHWE) and then purified and preconcentrated by three-phase hollow fiber liquid phase microextraction (HF-LPME) followed by LC-ESI-MS analysis. The PHWE was optimized with regard to the
Background: Medical treatment of hypertension is not always sufficient to achieve blood pressure control. Despite this, previous studies on supplementary therapies, such as yoga, are relatively few. We investigated the effects of two yoga interventions on blood pressure and quality of life in patients in primary health care diagnosed with hypertension. Methods: Adult patients (age 20-80 years) wit
BACKGROUND: Effective T-cell depletion is a prerequisite for haploidentical peripheral blood progenitor cell (PBPC) transplantation. This study was performed to investigate the performance of magnetic cell sorting–based direct large-scale T-cell depletion, which is an attractive alternative to standard PBPC enrichment procedures. STUDY DESIGN AND METHODS: PBPCs were harvested from 11 human leukoc
Abstract in French Cette étude a été réalisée pour déterminer si les papillomatoses virales du col sont associées à l'utilisation des contraceptifs et aux antécédents de reproduction. Après avoir enregistré les antécédents de contraception et de reproduction de 972 femmes ayant demandé des conseils en matière de contraception, des examens ont été conduits pour dépister toute infection de papillomaThe study was conducted to investigate whether cervical human papillomavirus infections (CHPI) are associated with contraceptive use and reproductive history. The contraceptive and reproductive histories in 972 women seeking contraceptive advice were noted and screening conducted for human papillomavirus infection. The interview included number of pregnancies and childbirths, legal and spontaneous
Mexico City’s water system is not sustainable. There is an unfair inequality gap in the quantity and quality of water access for its residents. Moreover, the groundwater aquifers in the city are being over-exploited and polluted. This has resulted in the sinking of the city, damage to the ecosystems, and the reduction of water access to Mexico City’s residents. As the policies are a direct instrum
Soil as a fundamental, conditionally renewable natural resource is increasingly under threat from unsustainable farming practices in a changing environment. In Hungary, expansive areas of land are susceptible to soil degradation, while only a small percentage of farmers currently applies soil conservation practices (SCPs). Degraded soils have an impact on food production, climate adaptation, clima
Objectives: Romania joined to European Union (EU) in 2007. Consequently, the number of EU citizens of Roma descent increased in Sweden as the movement of freedom was granted. This study attempts to understand the conceptualisation and reason for underreporting hate crimes in Malmö, Sweden. Methods: Qualitative data collection methods of semi-structured interview and participant observation were e
In recent years, the drawbacks of parallel systems in Disaster Risk Reduction (DRR) and Climate Change Adaptation (CCA) have been acknowledged in professional and academic communities, where the need for integration of the two fields in connection to development has been stressed. In this regard, the concept of resilience as an antithesis of risks has also been considered. In this study, a scoping
Tail risk metrics such as VaR and, especially ES are and have become of great importance to both investors and financial institutions such as banks in determining their amount of loss absorbing capital given the Basel framework. Estimating these metrics have become trivial, but to do it accurately while also taking market conditions such as periods of market stress into account still presents chal
Many extensions of the Standard Model, including those with dark matter particles, propose new mediator particles that decay into hadrons. This paper presents a search for such low mass narrow resonances decaying into hadrons using 140 fb−1 of proton-proton collision data recorded with the ATLAS detector at a centre-of-mass energy of 13 TeV. The resonances are searched for in the invariant mass sp
