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Endosomal entrapment is known to be a major bottleneck to successful cytoplasmic delivery of nucleic acids (NAs) using cationic liposome-NA nanoparticles (NPs). Quantitative measurements of distributions of NPs within early endosomes (EEs) have proven difficult due to the sub-resolution size and short lifetime of wildtype EEs. In this study we used Rab5-GFP, a member of the large family of GTPases
A hollow fiber supported liquid membrane module using one single fiber impregnated with a mixture of 1,10-dibenzyl-1,10-diaza-18-crown-6 and bis(2-ethylhexyl)phosphate dissolved in hexylbenzene was used for passive sampling of ppb levels of Pb(II), Cu(II), Zn(II), Mn(II), Ni(II), and Cd(II) in water. The target ions were simultaneously transported and preconcentrated into a citric acid acceptor so
Background: To study costs and outcome for serious hand and arm injuries during the first year after the trauma. Methods: In patients with a Hand Injury Severity Score (HISS) > 50, DASH and EQ-5D scores as well as factors related to costs within the health care sector, costs due to lost production and total costs were evaluated. Coxregression analysis stratifying for mechanism of injury was used t
We present the results of the first search for gravitational wave bursts associated with high energy neutrinos. Together, these messengers could reveal new, hidden sources that are not observed by conventional photon astronomy, particularly at high energy. Our search uses neutrinos detected by the underwater neutrino telescope ANTARES in its 5 line configuration during the period January - Septemb
Purpose: To assess baseline factors that may predict fast tibiofemoral cartilage loss over a 30-month period. Materials and Methods: The Multicenter Osteoarthritis (MOST) study is a longitudinal study of individuals who have or who are at high risk for knee osteoarthritis. The HIPAA-compliant protocol was approved by the institutional review boards of all participating centers, and written informe
Breast cancer is the most common cancer form among women in the Western world. Although treatment has improved during the last decades, there is still a significant proportion of the patients who are not cured. To further improve clinical outcome we need new treatment strategies, new prognostic markers, and new treatment predictive factors for personalized medicine.In this dissertation I have focu
High uncertainties are common in detailed quantification of the N budget of agricultural cropping systems. The process-based CoupModel, integrated with the parameter calibration method known as Generalized likelihood uncertainty estimation (GLUE), was used here to define parameter values and estimate an N budget based on experimental data from an organic farming experiment in south-west Sweden. Da
We study the mechanical failure of cemented granular materials (e.g., sandstones) using a constitutive model based on breakage mechanics for grain crushing and damage mechanics for cement fracture. The theoretical aspects of this model are presented in Part I: Tengattini et al. (2014), A thermomechanical constitutive model for cemented granular materials with quantifiable internal variables, Part
Technology foresight studies have become an important tool in identifying realistic ways of reducing the impact of modern energy systems on the climate and the environment. Studies on the future cost development of advanced energy technologies are of special interest. One approach widely adopted for the analysis of future cost is the experience curve approach. The question is, however, how robust
Aim: To compare treatment costs with alternative luteinizing hormone-releasing hormone (LHRH) agonist preparations and determine whether a leuprorelin solid implant is associated with potential cost savings. Patients & methods: A hypothetical population of 1000 prostate cancer patients was apportioned between the three most commonly-prescribed LHRH agonist preparations. Differentiated annual c
BACKGROUND AND PURPOSE: We used Riks-Stroke, the Swedish Stroke Register, to explore how thrombolysis has been disseminated in Swedish hospitals since it was approved in 2003. METHODS: All 78 hospitals in Sweden admitting patients with acute stroke participate in Riks-Stroke. Between 2003 and 2008, 72 033 adult patients were hospitalized for acute ischemic stroke. We analyzed thrombolysis use by r
Payment for water ecosystem services has been gaining attention in Latin America because of the direct response for environmental conservation through economic mechanisms. By connecting nature services with people who benefit from them, it creates a sustainable intervention for the ecosystem’s management while enhancing human well-being according to policy implementers. Nevertheless, these initiat
Accidents always get a lot of public attention. Journalists appear at the site of an accident, taking pictures and making interviews with professionals and eyewitnesses. With the emergence of smartphones, online-media, and social media platforms such as Twitter, Facebook, Instagram, etc. everyone became a journalist. It is no longer only accidents catching public attention but also near misses, sm
Climate-related security risks (CRSR) have risen on the foreign policy agenda of the European Union (EU). As climate change accelerates, its impacts exacerbate existing social, economic, and environmental challenges within and between communities and increase the likelihood of states experiencing humanitarian crises and conflict. These so-called climate-related security risks (CRSR), or climate-se
The relevance of M&E insights being utilized for reporting, contra planning purposes, for predicting level of outcome implementation have been neglected in previous literature. However, this study can show that when measurements and evaluations is used for future planning of communication activities, level of outcome implementation increase largely. This study can also predict the level of wh
For many years, indigeneity has been conceptualized as rural, making Indigenous communities and people in cities invisible globally. For the Sámi people, Europe’s only indigenous people, security is mainly understood as physical-centering extraction and environmental degradation. Focusing on the urban Sámi community in Umeå in Sweden, cultural and political belonging in the city arises as vital in
Buildings are a are a major consumer of energy in urban areas. The use of solar energy in buildings can help reduce CO2 emitting energy consumption in these urban areas. One way to use solar energy is through passive solar energy systems. Passive solar energy systems allow a building to use daylight as an energy source. The use of daylight as passive solar energy in Sweden could reduce the energy
The release of anthropogenic greenhouse gases (GHGs) has substantially increased the global mean surface air temperature. Increases in global mean surface air temperature will lead to warmer and drier conditions, promoting more frequent, long-lasting, intense forest wildfires. The usage of remote sensing (RS) can aid in quantifying forest characteristics and large-scale changes in forest ecosystem
Incorporating a multi-year grass ley into an arable crop rotation can increase soil organic carbon stocks, reduce carbon emissions and provide feedstock for biogas. This thesis set out to study how a policy promoting agricultural biomass for biogas impacts GHG emissions and carbon sequestration on a regional level over a temporal scale of 20 years. This was done in the specific case of policy prom
