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Objectives: To evaluate the feasibility of a population-based screening trial using prostate-specific antigen (PSA), a kallikrein panel and multiparametric magnetic resonance imaging (MRI) aimed at minimizing overdiagnosis, while retaining mortality benefit. Patients and Methods: Feasibility of the screening algorithm was evaluated in terms of participation, screening test results and cancer detec
OBJECTIVES: The objectives of this exploratory study were to investigate the feasibility of multidimensional diffusion magnetic resonance imaging (MddMRI) in assessing diffusion heterogeneity at both a macroscopic and microscopic level in prostate cancer (PCa).MATERIALS AND METHODS: Informed consent was obtained from 46 subjects who underwent 3.0-T prostate multiparametric MRI, complemented with a
AIM: Twelve to 13% of patients with colorectal cancer (CRC) develop peritoneal carcinomatosis (PC), the majority of whom present with unresectable disease. This study aimed to document the actual response rate to and response characteristics of preoperative modern systemic chemotherapy in this patient group.METHOD: Patients underwent a positron emission tomography (PET)/CT scan, laparoscopy and pe
The clinical translation of induced pluripotent stem cells (iPSCs) holds great potential for personalized therapeutics. However, one of the main obstacles is that the current workflow to generate iPSCs is expensive, time-consuming, and requires standardization. A simplified and cost-effective microfluidic approach is presented for reprogramming fibroblasts into iPSCs and their subsequent different
This study compared two different methods, the satellite altimetry-based and DEM (digital elevation model)-based, for estimating lake water volume changes. We focused on 34 lakes in China as the testing sites to compare the two methods for lake water volume changes from 2005 to 2020. The satellite altimetry-based method used water levels provided by the DAHITI (Database for Hydrological Time Serie
This paper examines corporate angels, small businesses that provide equity capital directly to unquoted ventures and become minority shareholders. Corporate angels have been largely ignored in entrepreneurial finance research. This novel study examines corporate angels' investment practices, goals and challenges by means of a combination of qualitative cases and a survey of 87 corporate angels. Fr
A cubic DNA nanocage probe is able to enter EVs derived from MDA-MB-231 cells and react with miRNA-10b. The probe-loaded EVs were employed to monitor the process of entry of miRNA-10b into MCF-10A cells, allowing visualization of EV-mediated intercellular communication of miRNA-10b between the cancer cells.
Ribosomes trapped on mRNAs during protein synthesis need to be rescued for the cell to survive. The most ubiquitous bacterial ribosome rescue pathway is trans-translation mediated by tmRNA and SmpB. Genetic inactivation of trans-translation can be lethal, unless ribosomes are rescued by ArfA or ArfB alternative rescue factors or the ribosome-associated quality control (RQC) system, which in Bacill
Background: Communication is a key tool in the nursing profession. It is known that listeners are sensitive to the speaker's voice and interpret the speaker's intentions primarily from the non-verbal signal conveyed. Aim: To map and discuss the current state of knowledge and research evidence on professional voice use in health and nursing care. Design and Method: A scoping review adherent to the
A new type of support for chromatographic use has been developed. Non-porous quartz fibre, with a mean diameter of 0.5 μm, was silylated with mercaptopropyltrimethoxysilane. Tresyl chloride-activated dextran was covalently coupled to the SH groups on the fibre. Remaining active tresyl groups on the dextran were then coupled with an NAD derivative.The affinity fibre contained 0.3 μmol NAD derivativ
Place branders express a desire for their work to aid in addressing crises such as climate change through sustainable developments that assist with brand positioning, yet little is known about how place branding professionals manage tensions and contradictions that arise between sustainability and investment development. This paper qualitatively explores how place branders talk about ecological su
In this blog, Jason Tucker, Associate Senior Lecturer at Malmö University, challenges the ways in which the international community programmatically engages with stateless refugees. Drawing on his research investigating the governance of stateless refugees, Jason argues that the statelessness of stateless refugees is systematically and chronically under-valued, sometimes with devastating consequen
The Danish scholar Johannes Munck proposed a connection between Paul's collection for Jerusalem and prophetic texts that envisage a pilgrimage of Gentiles to Zion in the end times. Nonetheless, Munck's seminal theory on the collection for Jerusalem has been contested in recent times. This article argues that the Pauline Epistles contain some textual evidence of this link between the two events and
Proximity testing is at the core of several Location-Based Services (LBS). Despite a series of reported and confirmed abuses, modern LBSs still demand their clients to disclose their locations in plain in order to preform location proximity testing. This works aims at enhancing proximity testing with privacy. We design CatNap a novel protocol that (1) implements precise Euclidean distance matching
Low-and-middle-income countries (LMICs) bear a high burden of intimate partner violence (IPV). However, there are no reviews assimilating the factors affecting risk of IPV in LMICs. This systematic review (2010–20) identifies risk and protective factors of IPV in LMICs. We followed the PRISMA guidelines to review 399 studies and included 32 studies. Studies were of ever-partnered women living in a
BACKGROUND: Precision medicine has the potential to improve cardiovascular disease (CVD) risk prediction in individuals with Type 2 diabetes (T2D).METHODS: We conducted a systematic review and meta-analysis of longitudinal studies to identify potentially novel prognostic factors that may improve CVD risk prediction in T2D. Out of 9380 studies identified, 416 studies met inclusion criteria. Outcome
