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Objective Uveal melanoma is a rare disease with poor prognosis and largely unknown etiology. We studied potential occupational risk factors. Methods A population based case-control study was undertaken during 1995-1997 in nine European countries using population and colon cancer controls with personal interviews. Occupational exposure to sunlight and artificial UV radiation was assessed with a job
An algorithm for the computation of mode I stress intensity factors of a square crack together with an error estimate is presented. The algorithm is based on a hypersingular integral equation. The leading singular behavior of the crack opening displacement in the corners is taken into account. The maximum value of the normalized stress intensity factor, Fmax, is estimated to Fmax=0.7534±0.0002. Pr
In this work a low power 5th order chebyshev active-RC low pass filter that meets Rel-8 LTE receiver requirements has been designed with programmable bandwidth and overshoot. Designed for a homodyne LTE receiver, filter bandwidths from 700kHz to 10MHz are supported. The bandwidth of the operational amplifiers is improved using a novel phase enhancement technique. The filter was implemented in 65nm
This paper presents a front-end architecture for fully integrated 60 GHz phased array receivers. It employs LO-path beamforming using a phase controlled phase-locked loop (PC-PLL). To demonstrate the architecture a circuit is implemented featuring a two stage low noise amplifier, two cascaded active mixers, and a PC-PLL. The receiver downconverts the 60 GHz signal in two steps, using LO signals fr
No current commercially available myoelectrically controlled prosthetic hands provide conscious sensory feedback to the user. A system aiming at relocation of sensory input from a prosthetic hand equipped with force sensors to the forearm skin of amputees, a tactile display, has been developed and constructed. The system consists of five piezoresistive force sensors or, alternatively, a prosthetic
In this paper we generalize the electricity spot price model of Lucia and Schwartz by a two-factor model with jumps and stochastic volatility. We estimate the model on daily spot price data from the Nordic market using an approach that combines traditional statistical methods with a Markov chain Monte Carlo algorithm. Results show that the model captures most of the trajectorial and the statistica
We consider classes G(s)([0, 1]) of subsets of [0, 1], originally introduced by Falconer, that are closed under countable intersections, and such that every set in the class has Hausdorff dimension at least s. We provide a Frostman-type lemma to determine if a limsup set is in such a class. Suppose that E = lim supE(n) subset of [0, 1], and that mu(n) are probability measures with support in E-n.
Objectives To determine the sensitivity and specificity of subjective evaluation of gray-scale and Doppler ultrasound findings (here called pattern recognition) when used by experienced ultrasound examiners with regard to making a specific diagnosis of adnexal masses. Methods Within the framework of a European multi-center study, the International Ovarian Tumor Analysis study, comprising nine ultr
A spatio-temporal model is constructed to interpolate yearly precipitation data from 1982 to 1996 over the African Sahel. The precipitation data used in the analysis comes from the Global Historical Climatology Network. The spatio-temporal model is based on a Gaussian Markov random field approach with AR(1)-dependence in time and a spatial component modeled using an approximation of a field withMa
The expression levels of fetal hemoglobin (HbF) in bacterial recombinant systems are higher compared with normal adult hemoglobin (HbA). However, heme disorientation in globins are often observed in recombinant production processes, both for HbA and HbF, although the degree of heme oriental disorder is much lower for HbF. In addition, the heme disorientation can be converted to a normal conformati
Based on an extensive cohort study over 25 years, the present study supports the assumption that major osteoporotic fractures can be reasonably predicted from hip fracture rates. The construct for FRAX models depends on algorithms to adjust for double counting of fracture outcomes in some models and in others, to estimate the incidence of a major fracture from hip fracture rates. The aim of the pr
Context: The diagnosis of and reporting parameters for prostate cancer (PCa) have evolved over time, yet they remain key components in predicting clinical outcomes. Objective: Update pathology reporting standards for PCa. Evidence acquisition: A thorough literature review was performed for articles discussing PCa handling, grading, staging, and reporting published as of September 15, 2011. Electro
This study uses a generalized linear model approach, i.e. negative binomial regression, to develop a predictive model for motorcycle fatal accidents on Malaysian primary roads. For the modeling process, a huge data inventory has been carried out, integrating the road geometry features, fatal accident records and traffic censuses from 3 selected states for the past 3-year period. The results show t
The dynamics and consequences of host-parasite coevolution depend on the nature of host genotype-by-parasite genotype interactions (G × G) for host and parasite fitness. G × G with crossing reaction norms can yield cyclic dynamics of allele frequencies ("Red Queen" dynamics) while G × G where the variance among host genotypes differs between parasite genotypes results in selective sweeps ("arms ra
When developing software-intensive products for a market-place it is important for a development organisation to create innovative features for coming releases in order to achieve advantage over competitors. This paper focuses on assessment of innovation capability at team level in relation to the requirements engineering that is taking place before the actual product development projects are deci
The blade tip region encounters high thermal loads because of the hot gas leakage flows, and it must therefore be cooled to ensure a long durability and safe operation. A common way to cool a blade tip is to design serpentine passages with a 180 deg turns under the blade tip-cap inside the turbine blade. Improved internal convective cooling is therefore required to increase blade tip lifetime. Pin
A neutron transport system for the planned imaging instrument ODIN at the future European Spallation Source (ESS) based on neutron optical components was designed and optimized. Different ways of prompt pulse suppression were studied. The spectral performance of the optimal neutron guide configuration is presented. In addition, the influence of the gaps in the guide system needed for the required
