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OBJECTIVES: To design and validate a scoring system for tomosynthesis (digital tomography) in pulmonary cystic fibrosis. METHODS: A scoring system dedicated to tomosynthesis in pulmonary cystic fibrosis was designed. Three radiologists independently scored 88 pairs of radiographs and tomosynthesis examinations of the chest in 60 patients with cystic fibrosis and 7 oncology patients. Radiograph
Detailed (222)radon (Rn-222) flux maps are an essential pre-requisite for the use of radon in atmospheric transport studies. Here we present a high-resolution Rn-222 flux map for Europe, based on a parameterization of Rn-222 production and transport in the soil. The Rn-222 exhalation rate is parameterized based on soil properties, uranium content, and modelled soil moisture from two different land
A modification of the Roe scheme called L2Roe for low dissipation low Mach Roe is presented. It reduces the dissipation of kinetic energy at the highest resolved wave numbers in a low Mach number test case of decaying isotropic turbulence. This is achieved by scaling the jumps in all discrete velocity components within the numerical flux function. An asymptotic analysis is used to show the correct
Introduction and hypothesis Urinary incontinence (UI) is common among the elderly, but the literature is sparse on the surgical treatment of UI among the elderly. This systematic review aims to assess the effectiveness of surgical interventions as treatment for urinary incontinence in the elderly population >= 65 years of age. Methods Randomized controlled trials (RCT) and prospective nonrandomize
PET with F-18-choline (F-18-FCH) is used in the diagnosis of prostate cancer and its recurrences. In this work, biodistribution data from a recent study conducted at Skane University Hospital Malmo were used for the development of a biokinetic and dosimetric model. Methods: The biodistribution of F-18-FCH was followed for 10 patients using PET up to 4 h after administration. Activity concentration
Despite the importance of regioselective reductive openings of cyclic acetals, mechanistic details are scarce. In this study 4,6-O-benzylidene acetals were used as model compounds for deciphering the mechanism of regioselective openings using a variety of reducing agents. Competitive isotopic studies aiming at primary and secondary isotope effects, as well as an electron-deficient substrate, were
Type 2 diabetes carries a risk for hypoglycemia, particularly in patients on an intensive glucose control plan as a glucose-lowering strategy, where hypoglycemia may be a limitation for the therapy and also a factor underlying clinical inertia. Glucose-lowering medications that increase circulating insulin in a glucose-independent manner, such as insulin and sulfonylurea therapy, are the most comm
Seven strongly supported clades, characterised by molecular, morphological and anatomical characters are described as new genera: Eilifdahlia, Elenkiniana, Franwilsia, Huneckia, Marchantiana, Mikhtomia and Yoshimuria. Two new species, Eilifdahlia wirthii from South Africa and Marchantiana maulensis from Chile are described, illustrated and compared with closely related taxa.
Complement convertases are enzymatic complexes that play a central role in sustaining and amplification of the complement cascade. Impairment of complement function directly or indirectly leads to pathologic conditions including higher infection rate, kidney diseases, autoimmune- or neurodegenerative diseases and ischemia-reperfusion injury. An assay for direct measurement of activity of the conve
Soot, which is produced from biomass burning and the incomplete combustion of fossil and biomass fuels, has been linked to regional and global climate change and to negative health problems. Scientists measure the properties of soot using a variety of methods in order to quantify source emissions and understand its atmospheric chemistry, reactivity under emission conditions, interaction with solar
A solid target system was developed for a PET cyclotron. The system is compatible with many different target materials in the form of foils and electroplated/sputtered targets which makes it useful for production of a wide variety of different PET radionuclides. The target material is manually loaded into the system. Remote handling of irradiated target material is managed with a pneumatic piston
Measurements of water content profiles are of great interest in hydrology and soil science. Time domain reflectometry (TDR) is a well-established method for water content measurements; however, most TDR probe designs are suitable for measurements in only a small soil volume. In this article, a 1-m long TDR profiling probe with five measurement sections is described. Unlike most other previous prof
Abstract A major drawback with myoelectric prostheses is that they do not provide the user with sensory feedback. Using a new principle for sensory feedback, we did a series of experiments involving 11 healthy subjects. The skin on the volar aspect of the forearm was used as the target area for sensory input. Experiments included discrimination of site of stimuli and pressure levels at a single st
The prognosis for malignant gliomas remains poor, and new treatments are urgently needed. Targeted suicide gene therapy exploits the enzymatic conversion of a prodrug, such as a nucleoside analog, into a cytotoxic compound. Although this therapeutic strategy has been considered a promising regimen for central nervous system (CNS) tumors, several obstacles have been encountered such as inefficient
In this investigation, a gas chromatography/mass spectrometry (GC/MS)-based metabolomic protocol for adherent cell cultures was developed using statistical design of experiments. Cell disruption, metabolite extraction, and the GC/MS settings were optimized aiming at a gentle, unbiased, sensitive, and high-throughput metabolomic protocol. Due to the heterogeneity of the metabolome and the inherent
OBJECTIVE: To develop a psychometrically appropriate brief symptoms measure of carpal tunnel syndrome (CTS). METHODS: Preoperative CTS 11-item symptom severity and 8-item functional status scales from 693 patients (71% women) with CTS were subjected to exploratory factor analysis and item response theory (IRT) analysis yielding a revised CTS symptoms scale. A validation sample of 213 patients (68%
This thesis is concerned with the subject of craft and technology and the intricate connection between man, his objects and society. When archaeologists study social and cultural structures and phenomena, it is understood that the objects have been created and crafted by people, but the weight of this fact is not always recognized. Acknowledging that we are always studying the material expression
OBJECTIVE: To evaluate outcome and patency predicting factors of kissingstent treatment for aorto iliac occlusive disease (AIOD). METHODS: Patients treated with kissingstents for AOID between 1995 and 2004 at a tertiary referral center were identified through local databases. Chart review and preoperative images were used for TASC and Fontaine classification. Follow-up consisted of clinical exams,
