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Arginine-rich cell penetrating peptides (ARCPPs) are known to quickly permeate cell membranes through a non-endocytotic pathway. Potential clinical applications of this facility have prompted enormous effort, both experimental and theoretical, to better understand how ARCPPs manage to overcome the prodigious thermodynamic cost of lipid bilayer permeation by these highly charged peptides. In this w
Realistic radio channel models are crucial for the success of vehicle-to-vehicle (V2V) system investigations. In this paper, we summarize the important parameters for V2V channel models and describe relevant measurement campaigns. Also, we develop and evaluate an ns-3 simulation model of a realistic V2V channel model that is based on measurements in Sweden. The channel model incorporates the effec
Background: There is currently a steady increase in the use of wood-based fuels for heat and power production in Sweden. A major proportion of these fuels could serve as feedstock for ethanol production. In this study various options for the utilization of the solid residue formed during ethanol production from spruce, such as the production of pellets, electricity and heat for district heating, w
Objective To determine whether environmental control using nocturnal temperature controlled laminar airflow (TLA) treatment could improve the quality of life of patients with persistent atopic asthma. Design Randomised, double-blind, placebo-controlled, parallel-group trial. Setting Nineteen European asthma clinics. Participants 312 patients aged 7-70 with inadequately controlled persistent atopic
Popular Abstract in Swedish De flesta cancerpatienter dör på grund av spridning av tumörceller till olika organ. Invasiv och metastaserande cancer svarar ofta inte på behandling och blir då i många fall dödlig. Leukemi är en elakartad sjukdom av blodceller, som påverkar blod-producerande organ. Den höga förekomsten av leukemi förekommer i äldre befolkningen och hos barn. Leukemi återfall och resiThe majority of current treatments used for treatment of prostate cancer (PCa) and leukemia are often limited to a narrow subsets of treated patients. As such, there still remains a significant scope for gaining deeper understanding of molecular mechanisms underlying cancer metastasis for improvement of targeted treatment. Elevated expression of a cell cycle regulator cyclin A1 initiated leukemia
Removal of disease-driving inflammatory leucocytes is central to resolution of inflammation. The current pharmacological dogma teaches leucocyte elimination through apoptosis followed by phagocytosis. However, actual resolving roles of apoptotic-phagocytic processes have been difficult to demonstrate in the major diseases that are characterized by mucosal tissue inflammation. Many current in vivo
We report on a setup for the investigation of proton acceleration in the regime of target normal sheath acceleration. The main interest here is to focus on stable laser beam parameters as well as a reliable target setup and diagnostics in order to do extensive and systematic studies on the acceleration mechanism. A motorized target alignment system in combination with large target mounts allows fo
Chronic myeloid leukemia (CML) is characterized by a specific chromosome translocation, and its pathobiology is considered comparatively well understood. Thus, quantitative analysis of CML and its progression to blast crisis may help elucidate general mechanisms of carcinogenesis and cancer progression. Hitherto, it has been widely postulated that CML blast crisis originates mainly via cell-autono
A detector with high dynamic range designed for combined small-and wide-angle x-ray scattering experiments has been developed. It allows measurements on single events and reactive systems, such as particle formation in flames and evaporation of levitating drops. The detector consists of 26 channels covering a region from 0.5 degrees to 60 degrees and it provides continuous monitoring of the sample
This study evaluated the sample sizes necessary to estimate several soil and vegetation characteristics within 10% confidence intervals with 95% probability in three terra firme tropical rainforest sites. Across all three plots, the most spatially heterogeneous variables were measurements of total standing crop root mass, ground surface litter mass, litter fall, root growth and soil respiration wh
The modelling of damage effects in materials constitutes a major challenge in various engineering-related disciplines. However, the assumption of purely local continuum damage formulations may lead to ill-posed boundary value problems and—with regard to numerical methods such as the finite element method—to mesh-dependent solutions, a vanishing localised damage zone upon mesh refinement, and hence
In this paper, a novel multiple representation data structure for dynamic visualisation of 3D city models, called CityTree, is proposed. To create a CityTree, the ground plans of the buildings are generated and simplified. Then, the buildings are divided into clusters by the road network and one CityTree is created for each cluster. The leaf nodes of the CityTree represent the original 3D objects
The three-year research project funded by MSB applies design science, in combination with traditional scientific investigation, to develop a method to guide the planning phase of capacity development projects for disaster risk reduction and climate change adaptation. The method facilitates local participation and ownership as it builds on the strengths of the Logical Framework Approach (LFA), whil
Isotropic chiral media can be modelled in several ways. We show that when realizing such a medium from spiral inclusions with real permittivities and permeabilities in a periodic structure, a modified Drude–Born–Fedorov model is obtained. This model equals the original Born model for small wave vectors, but the strength of the chirality depends on the propagation direction. The effective parameter
We present the design of a split-and-delay unit for the production of two delayed replicas of an incident extreme ultraviolet (XUV) pulse. The device features a single grazing incidence reflection in combination with attenuation of remaining infrared light co-propagating with the XUV beam, offering a high throughput without the need of introducing additional optics that would further decrease the
Objective. To analyse the management of muscle-invasive bladder cancer in a population-based national register, and specifically to investigate the role of curative therapy (i.e. cystectomy or radiotherapy) in relation to patient, tumour and hospital characteristics. Material and methods. The Swedish Bladder Cancer Register covers more than 90% of all patients in the country who have been diagnose
Large and strongly growing organizations tackle the issue of finding a way to decide which business requirements to fulfill and which projects to move forward but often forget the strategic. Once a strategy has been developed, its implementation appears to be seen as a matter of operational detail and tactical adjustment. As efforts and resources risk to be put on the wrong projects, how do you ma
Since the aging problem became increasingly serious all around the world, the solution of aged care turns to an important issue which received wide concerning. As China own the one fifth population of the world, a well formed aged care system is urgently needed. The aim of this paper is to explore a possible form to relieve the more and more severe aged care pressure by taking Hangzhou as an empir
