Filetype
In mitosis, the Greatwall kinase (called microtubuleassociated serine/threonine kinase like [Mastl] in mammals)is essential for prometaphase entry or progression by suppressing protein phosphatase 2A (PP2A) activity. PP2A suppression in turn leads to high levels of Cdk1 substrate phosphorylation. We have used a mouse model with an oocyte-specific deletion of Mastl to show that Mastl-null oocytes r
Staphylococcal toxic shock syndrome is a potentially lethal illness attributed to superantigens produced by Staphylococcus aureus, in particular toxic shock syndrome toxin 1 (TSST-1), but staphylococcal enterotoxins (SEs) are also implicated. The genes encoding these important toxins are carried on mobile genetic elements, and the regulatory networks controlling expression of these toxins remain r
ClpP is the proteolytic subunit of the ATP-dependent Clp protease in eubacteria, mammals and plant chloroplasts. Cyanobacterial ClpP protein is encoded by a multigene family, producing up to four distinct isozymes. We have examined the importance of the first ClpP protein (ClpP1) isolated from the cyanobacterium Synechococcus sp. PCC 7942 for acclimation to ecologically relevant UV-B and low-tempe
Previously genome-wide association methods in patients with classic bladder exstrophy (CBE) found association with ISL1, a master control gene expressed in pericloacal mesenchyme. This study sought to further explore the genetics in a larger set of patients following-up on the most promising genomic regions previously reported. Genotypes of 12 markers obtained from 268 CBE patients of Australian,
BACKGROUND: Neutrophil extracellular traps (NETs) are known to play an important role in the pathophysiology of acute pancreatitis (AP). Activation of the complement cascade has been shown to occur in AP. The aim of this study was to examine whether complement component 3 is involved in the generation of NETs in AP.METHODS: AP was induced in wild-type and C3-deficient mice by retrograde infusion o
C4b-binding protein (C4BP) regulates the classical pathway C3-convertase of the complement system. Human C4BP is composed of seven identical subunits (alpha-chains) and one unique one (beta-chain). Both types of chains contain homologous repeats called complement control proteins (CCPs); the alpha-chain contains eight CCPs and the beta-chain three. Each alpha-chain contains a binding site for C4b
Economic behavior highlights the importance of differences in individual characteristics like cognition and emotional regulation strategy in predicting the selection and performance of economic choices. However, the literature on value premium has overlooked the effect of cognition and emotional regulation strategy in assessing individual preference to select value versus growth stocks. We fill th
Background: The purpose of this analysis was to revisit the open US Food and Drug Administration (FDA) inspection list results from clinical trials and show the possibilities of evaluating inspection results between different world regions and explore what aspects of clinical trial deficiencies are most often reported.Aims: The aim of this study was to evaluate inspection results from different re
This study investigates the link between the personality profiles and socio-demographic characteristics of wine consumers and the sensory characteristics of the wines they prefer. This was measured in terms of a self-reported list of the wines they like and buy. The 1176 Italian adults who participated were asked to complete an online form. Information was collected regarding certain socio-demogra
This disquisition explores the possibilities to install a battery storage situated in a gasturbineplant to enable a start up of the gasturbine in the case of a powerfailure. Since powerfailures are rare, the battery will mostly and to a large extent be unused, this creates an economic dilemma. Uniper has taken in and recieved a tender which includes and discribes a battery with a larger storage sy
The emergence of blockchain technology enables entrepreneurs to raise capital in an innovative way, by addressing a crowd of online investors without the need for an intermediary. This phenomenon is known as token sales, and it may have the potential to revolutionize entrepreneurial finance. However, information asymmetry is particularly severe in this context, and the need for entrepreneurs to se
The aim of this article is to draw attention to the dangerous, indeed poisonous, nature of the current debates on immigration and multiculturalism in today’s ‘omniphobic’ Europe, plagued not only by a severe economic crisis, but also a more general normative crisis, a ‘crisis of values’ so to speak, which has been consistently overlooked or manipulated by politicians and academics alike, or reduce
In ESS, a 5 MW proton beam will hit a helium cooled tungsten target to generate neutrons by spallation. For the purpose of investigating various aspects of cooling with helium, an experimental system has been constructed at Lund University, Department of Energy Sciences. A helium flow of 3 g/s is circulated in a closed loop with pre-heater, cooler, filters and a test vessel. The vessel has windows
Medieval Europe was characterized by geopolitical disorder and territorial disunion. Around 1500 AD, as the modern era dawned, Europe comprised some 1,500 districts which were largely politically independent. Gradually, medium sized territories emerged around cores made up of cultural, economic, and political centres. The Lake Malar area in Sweden was such a territory; London, Paris, Berlin-Potsda
A growing body of research highlights how the Internet and social media offer new platforms for advocacy. This article contributes to the debates on digital advocacy by combining interest group and social media studies and present the notions of digital access politics, digital information politics, and digital protest politics for a comprehensive analysis of digital advocacy. Based on a netnograp
Drawing upon the perspective of the cultural studies of emotions, this article examines the reception of political satire and the re-contextualization of humour. More precisely, it investigates the multiplicity of tensions that come into play in the production, erasure, rediscovery, and reception in BelarusianInternet media of politically oriented Russian television humour mocking the Belarusian p
