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This chapter analyses the role that 'ordre public' and morality exceptions can play in the granting of patents on inventions in the field of human germline editing and the consequences of this policy option. In order to provide the context for such an analysis, the chapter will, first, provide an overview of the current patent landscape for relevant genome editing technologies, drawing attention t

BACKGROUND: The ongoing TANGO2 (Telephone Assisted CPR. AN evaluation of efficacy amonGst cOmpression only and standard CPR) trial is designed to evaluate whether compression-only cardiopulmonary resuscitation (CPR) by trained laypersons is noninferior to standard CPR in adult out-of-hospital cardiac arrest. This pilot study assesses feasibility, safety, and intermediate clinical outcomes as part

Scanning coherent X-ray microscopy (ptychography) has gained considerable interest during the last decade since the performance of this indirect imaging technique does not necessarily rely on the quality of the X-ray optics and, in principle, can achieve highest spatial resolution in X-ray imaging. The method can be easily extended to 3D by adding standard tomographic reconstruction schemes. Howev

The knowledge of the material budget with a high precision is fundamental for measurements of direct photon production using the photon conversion method due to its direct impact on the total systematic uncertainty. Moreover, it influences many aspects of the charged-particle reconstruction performance. In this article, two procedures to determine data-driven corrections to the material-budget des

BACKGROUND: ATOR-1017 (evunzekibart) is a human agonistic immunoglobulin G4 antibody targeting the costimulatory receptor 4-1BB (CD137). ATOR-1017 activates T cells and natural killer cells in the tumor environment, leading to immune-mediated tumor cell death.METHODS: In this first-in-human, multicenter, phase I study, ATOR-1017 was administered intravenously every 21 days as a monotherapy to pati

Breast cancer is the most common type of cancer in women worldwide. Triple-negative breast cancer (TNBC) is a subtype of breast cancer that lacks the expression of the oestrogen receptor, progesterone receptor, and amplification of HER2. This subtype is the most aggressive subtype and a heterogeneous subgroup of breast cancer, making up around 10-15% of the cases, often affecting younger patients

Introduction: Cardiac arrest is characterized depending on location as in-hospital cardiac arrest (IHCA) or out-of-hospital cardiac arrest (OHCA). Strategies for Post Cardiac Arrest Care were developed based on evidence from OHCA. The aim of this study was to compare characteristics and outcomes in patients admitted to intensive care after IHCA and OHCA. Methods: A retrospective multicenter observ

nutrients Article Daily Intake of Milk Powder and Risk of Celiac Disease in Early Childhood: A Nested Case-Control Study Elin M. Hård af Segerstad 1, Hye-Seung Lee 2, Carin Andrén Aronsson 1 ID , Jimin Yang 2, Ulla Uusitalo 2, Ingegerd Sjöholm 3, Marilyn Rayner 3 ID , Kalle Kurppa 4, Suvi M. Virtanen 5, Jill M. Norris 6, Daniel Agardh 1,* ID and on behalf of the TEDDY Study Group 1 The Diabetes an

https://www.teddy.lu.se/sites/teddy.lu.se/files/2021-11/91%2010262018_679_91_MP169_Hard%20af%20Segerstad_Nutrients_2018.pdf - 2026-05-26

Leukemic cells from 85 children with newly diagnosed precursor B-lineage ALL were tested for in vitro drug sensitivity to a panel of anti-cancer drugs. Minimal residual disease (MRD) was measured by RQ-PCR. There was a significant correlation between MRD day 29 and in vitro sensitivity to prednisolone (p < 0.001) and doxorubicin (p = 0.01 7), drugs administered during induction therapy. In patient

The base (BOP) and the top (TOP) of the world income pyramid represent the poor people and the people from developed countries, respectively. About two-fifths of the world population can be categorized as poor. Poverty is a trap because children born to poor parents are likely to grow up to be poor adults. In recent years, a poverty reduction approach that combines business development with povert

High performance requirements increased the popularity of unconventional architectures. While providing better performance, such architectures are generally harder to program and generate code for. In this paper, we present our approach to ease programmability and code generation for such architectures. We present a domain specific language (DSL) for the programming part, and a constraint programm

The aim of this work was to investigate and quantify the effects of system noise, nodule location, anatomical noise and anatomical background on the detection of lung nodules in different regions of the chest x-ray. Simulated lung nodules of diameter 10 mm but with varying detail contrast were randomly positioned in four different kinds of images: 1) clinical images collected with a 200 speed CR s

Mitochondrial abnormalities may be involved in PTSD, although few studies have examined this. Mitochondrial DNA copy number (mtDNAcn) in blood cells is an emerging systemic index of mitochondrial biogenesis and function. The present study assessed mtDNAcn in male combat-exposed veterans with PTSD compared to those without PTSD as well as its correlation with clinical scales.

Popular Abstract in Swedish Robust konstruktion handlar om hur produkter skall konstrueras för att bli okänsliga mot oväntade störningar och variationer i t.ex. omgivningen under drift. Normalt har detta problem angripits med den sk. Taguchi-metoden, i vilken experiment utförs efter en viss metodik på en prototyp, varefter produktens beteende kartläggs och konstruktionsvariablerna väljs så att ettThe activity of robust design of mechanical products and how it can be accomplished in pre-prototype design phases, is discussed in this thesis. It is advocated that to be fully efficient and effective optimization of product robustness should commence already in the conceptual design phase. Moreover, since product optimization is a process, robust design should be perceived and implemented as a p

Alltsedan det kalla kriget slutade har försvarssektorn, framförallt militär logistik och försvarsmaterielanskaffning, genomgått en genomgripande transformation. Flera faktorer har bidragit till transformationen: förändringar i länders och organisationers försvars- och säkerhetspolitik; reducerade försvarsbudgetar; deltagande i fredsbevarande och fredsframtvingande operationer; erfarenheter från deSince the ending of the Cold War, the defence sector, particularly the areas of military logistics and defence acquisition, has been undergoing a comprehensive transformation. There are several factors that explain this transformation: changes in defence and security policies for nations and organisations; reductions in defence expenditure; participation in Peace Support Operations; Lessons Learne

The function of the nucleolus is intimately connected to cell proliferation, division and growth. Many cancer cells have enlarged nucleoli, and several nucleolar proteins have been linked to tumorigenesis. In order to find proteins whose expression is altered in the nucleoli of leukemic cells, we carried out two-dimensional difference gel electrophoresis (2-D DIGE) analyses. Prohibitin (PHB) and T

Two different antennas for use in implanted pacemakers are analyzed by simulation and measurement. The analysis was made with an FDTD-code. The simulations and measurements show good agreement. The SAR values for both the antennas are within the limits recommended by ICNIRP when the antenna is fed with 25 uW.

Lojalitetsplikten, även benämnd lojalitetsprincipen, är en allmän rättsprincip i svensk avtalsrätt som innebär en plikt att beakta motpartens intressen utö-ver avtalets reglerade utfästelser. Definitioner av lojalitetsplikten ger inte mycket ledning för hur den ska förstås. Vad som därför är relevant är hur begreppet används. Generellt vilar lojalitetsplikten på outtalade förpliktelser som utgår fThe duty of loyalty, also known as the principle of loyalty, is regarded as a general principle of law in Swedish contract law. It implies a duty to observe the interests of the counter-party beyond the regulated obligations in the contract. Different definitions of the duty of loyalty do not give much advice as of how it should be interpreted. Therefore, what is relevant is how the principle is b